Department of Innovative Science & Technology for  Bio-industry


Major measuring and analyzing devices in the Department of innovative Science and Technology for Bio-industry

The Department of Innovative Science and Technology for Bio-industry is established only for Ph.D. candidate students, which consists of two educational courses, Bio-System Design and Functional Biomaterials Design. Since the department aims to establish an effective and productive cooperative framework for bio-industry and academia, most of the research projects are welcomed to collaborate with bio-industry companies. The projects cover a wide range of research fields of bioscience and biotechnology, however, main objective of the department is to promote a new innovative research field able to design metabolic regulations and networks to produce functional biomaterials, named: Metabolic Architecture Design System. The objectives of four educational courses are as follows:


Educational Course 1: Bio-System Design

In this course, collaborating with bio-industries, practical research subjects in gene network, metabolic system and bioprocess system are covered. This course is concerned with professional leading researchers who have potential to design the strategies and improvement methods for the higher production of target biomaterials in bio-production system with using measurement technologies, computer simulation and mathematical science studies

1.Applied Biological Regulation Technology

Masahiro OKAMOTO, Ph.D., M.Sc., Professor
Taizo HANAI, Ph.D., M.Sc., Associate Professor
Hiroyuki HAMADA, Ph.D., M.Sc., Assistant Professor

1) Development of a system for the inference of larger scale genetic networks
2) Development of biochemical engineering analyzing tool-kit
3) Nonlinear numerical optimization technique based on evolutional computing (genetic algorithm, genetic programming)
4) Bioinspired design of adaptive routing of packets and traffic congestion control
5) Improvement of biofuel production by metabolic engineering
6) Construction of artificial gene network by synthetic biology
7) Mathematical modeling of cell cycle arrest and apoptosis
8) Mathematical modeling of synchronization of heart beating rhythms
2.Molecular Gene Technology

Satoru KUHARA, Ph.D., M.Sc., Professor
Kosuke TASHIRO, Ph.D., M.Sc., Associate Professor
Shigeru MUTA, Ph.D., M.Sc., Assistant Professor

1) The cellular gene regulation system using experimental and computational strategy
2) Identification of gene regulatory network
3) Gene regulation in cellular differentiation
4) Microbial Genome, Development of systems for environmental microorganism
3.Food Analysis

Toshiro MATSUI, Ph.D., M.Sc., Professor
Mitsuru TANAKA, Ph.D., M.Sc., Assistant Professor

1) Development of functional foods (Hypertension, Diabetes, Lifestyle-related diseases) and elucidation of their physiological mechanism(s)
2) Absorption of bioactive compounds and their mechanism
3) Sorption of volatiles into plastic film (Diffusion, Permeation, Solubility, SP value, Polymer)
4.Microbial Technology

Kenji SONOMOTO, Ph.D., M.Sc., Professor
Jiro NAKAYAMA, Ph.D., M.Sc., Associate Professor
Takeshi ZENDO, Ph.D., M.Sc., Assistant Professor

1) Diversified microbial utilization of renewable resources (Biodegradable plastic materials, Biodiesel fuel, Medically functional foods and food materials)
2) Bioprocess development and control of anaerobic fermentation (Lactic acid fermentation, Acetone-butanol-ethanol fermentation)
3) Biochemistry, genetics and fermentation of bacteriocins of lactic acid bacteria
4) Peptide engineering of lantibiotics containing unusual amino acids
5) Characterization of microbial diversity in fermented foods and human intestine by molecular approaches (Nukadoko, Correlation between microflora and allergy)
6) Characterization of chemical signals controlling microbial behavior (Bacterial pheromone)
5.Metabolic Architecture Design

Hiroyuki WARIISHI, Ph.D., M.Sc., Professor

1) Systems Biology of Lignin Biodegradation
2) Omic Studies on Basidiomycetes
3) Metabolic Architecture Design for the higher production of target metabolites
4) Applied Enzymology and Microbiology
6.Bio-Process Design

Fumihide SHIRAISHI, Ph.D., M.Sc., Professor

1) Development of an efficient method for analysis of large-scale metabolic reaction systems
2) Dynamic sensitivity analysis of large-scale metabolic reaction systems
3) Development of photocatalytic processes for purification of air and water

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Educational Course 2: Functional Biomaterials Design

This course covers a wide range of research fields on functional biomaterials such as, intense system-analysis of microbial/plant/animal models with using genetic manipulation, effective production of functional food factors, development of novel architecture of functional bio-based materials and so on.

1.Marine Resource Chemistry

Makoto ITO, Ph.D., M.Sc., Professor
Nozomu OKINO, Ph.D., M.Sc., Associate Professor

1) Marine biotechnology and microbiology (Novel enzymes, Inhibitors, Polyunsaturated fatty acids, Labyrinthulea)
2) Glycobiology/technology and lipidbiology/technology (Glycosphingolipids, Sphingolipids, Metabolism, Microdomains, Signal transduction, Post-translational modification)
3) Infection and symbiosis of microbes (Receptor, Fish pathogens, Opportunistic pathogens, Atopic dermatitis)
2.Food Chemistry

Koji YAMADA, Ph.D., M.Sc., Professor
Hirofumi TACHIBANA, Ph.D., M.Sc., Professor
Michiko NONAKA, Ph.D., M.Sc., Research Associate

1) Physiologically functional factors in foods (Proteins, Lipids, Fibers, Antioxidants)
2) Functional assessment of food ingredients (Biochemical tests, Animal cell culture, Animal tests)
3) Prevention of food allergy (Allergen degradation, Control of Ig production, Control of chemical mediator production)
4) Prevention of carcinogenesis
5) Identification and application of the molecular targets of functional food factors
6) Characterization and application of green tea polyphenols signaling pathway
3.Biomacromolecular Materials

Daisuke TATSUMI, Ph.D., M.Sc., Associate Professor

1) Creation of Novel Fibrous Materials from Natural Polymer Solutions (liquid crystal, fiber, film, gel)
2) Functionalization of Biomacromolecular Materials (Cellulose, Chitin etc.)
3) Structure and Rheological Properties of Fiber Networks (floc, viscoelasticity, power law)
4.Cellular Regulation Technology

Sanetaka SHIRAHATA, Ph.D., M.Sc., Professor
Yoshinori KATAKURA, Ph.D., M.Sc., Associate Professor
Kiichiro TERUYA, Ph.D., M.Sc., Assistant Professor

1) Development of functional waters and foods for prevention and improvement of oxygen-stress-related diseases
2) Analysis of molecular basis for aging and its application to development of anti-aging foods
3) Efficient preparation of human monoclonal antibodies by using in vitro immunization and gene technology
5.Metabolic Regulation Research

Shigeki FURUYA, Ph.D., M.Sc., Professor

1) Functional genomic analysis of animal models for human serine deficiency (knockout mouse, metabolic disease model, brain dysfunction, neuron-glia interaction)
2) Molecular basis for metabolite-gene regulatory networks in animal nervous tissues (amino acids, brain, transcriptomics, proteomics, metabolomics)
3) Molecular mechanisms underlying recognition of amino acids deficiency (metabolic homeostasis, cell function, signal transduction)
6.Biomaterial Design

Tetsuo KONDO, Ph.D., M.Sc., Professor
Shingo YOKOTA, Ph.D., M.Sc., Assistant Professor

1) A hierarchical organizing design for 3-D nano/micro architecture of bio-based materials
2) Safe and comfortable nano-materials from microbial cellulose fibers
3) Nano-dispersion and dissolution of biomass into water using aqueous counter collision
4) Functionalization of nano-building blocks from bio-based materials
5) Encouraging protoplasts and cells to produce materials by environmental stress
6) Manipulation of movements for microorganisms and cells
7) Surface modification of bio-based nano-materials

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