2011

1. 鵜殿, Nature, 472: 226-269 (2011)
   

2. Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan
   

3. 門岡, Nature, 452: 1012-1016 (2008)
   Upper intestinal lipids trigger a gut-brain-liver axis to regulate glucose production
   

4. 山下, J. Neurochem., 77: 425-434 (2001)
   Protein kinase C delta regulates neural cell adhesion molecule polysialylation state in the rat brain
   

5. Pawat, PNAS, 108: 6603-6608 (2011)
   Peroxisome proliferator-activated receptor-γ coactivator 1-α (PGC-1α) is a metabolic regulator of intestinal epithelial cell fate
   

6. 續, Science, 324: 654-657 (2009)
   Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1
   

7. 黒田, Biochem. Pharmacol., 81: 534-543 (2011)
   The peroxisome proliferator-activated receptor β/δ (PPARβ/δ) agonist GW501516 prevents TNF-α-induced NF-κB activation in human HaCaT cells by reducing p65 acetylation through AMPK and SIRT1
   

8. 原田, JBC, 284: 18210-18217 (2009)
   SirT1 is an inhibitor of proliferation and tumor formation in colon cancer
   

9. 藤井, PLoS One, 6: e17971 (2011)
   Effects of dietary supplementaion of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficts in 3xTg-AD moice
   

10. 山下, FASEB J., 24: 1442-1453 (2009)
    Glucose restriction can extend normal cell lifespan and impair precancerous cell growth through epigenetic control of hTERT and p16 expression.
    

2010

1. 鵜殿, Aging Cell, 8: 311-323, 2009
   DNA damage response and cellular senescence in tissues of aging mice
   

2. 門岡, PNAS, 106: 17031-17036, 2009
   Cell surface-bound IL-1α is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network.
   

3. 山下, PLoS One, 5: e11457, 2010
   Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines.
   

4. 山下, BBA, 1592: 205-211, 2002
   Inhibition of histone acetyltransferase of p300 by PKCδ
   

5. Pawat, Cell, 142: 320, 2010
   SIRT1 suppresses β-amyloid production by activating the α-secretase gene ADAM10
   

6. 續, Nature, 462: 1061, 2009
   Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila
   

7. 藤田, PLoS One, 4: e5622, 2009
   Polycomb mediated epigenetic silencing and replication timing at the INK4a/ARF locus during senescence.
   

2009

1. 鵜殿, Nature, 458: 1056-1060, 2009
   AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
   

2. 横田, J. Immunol., 180: 5653-5661 (2008)
   Mechanism of IL-1-β-induced increase in intestinal epithelial tight junction permeability
   

3. 伊藤, Nature, 459: 262-265 (2009)
   Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
   

4. 銭, Cell, 131: 861-872 (2007)
   Induction of pluripotent stem cells from adult human fibroblasts by defined factors
   

5. 山下, Cell, 135: 609-622 (2008)
   Telomerase reverse transcriptase delays aging in cancer-resistant mice
   

6. 出口, BBRC, 382: 577-582 (2009)
   Neuroplasticity and neuroprotecton in enteric neurons: Role of epithelial cells
   

7. 小畠, Cell, 137: 1088-1099 (2009)
   Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation
   
   

8. 鵜殿, Nat. Med., 15: 1082-7 (2009)
   A crucial role of adipose tissue p53 in the regulation of insulin resistance
   

9. 伊藤, Nature, 460: 66-72 (2009)
   Telomerase modulates Wnt signalling by association with target gene chromatin
   

10. 小畠, Nat. Cell Biol., 11: 973-9 (2009)
    Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
    

11. 横田, Cancer Sci., 100: 1275-1283 (2009)
    Level of reactive oxygen species induced by p21 is critical for the determination of cell fate
    

12. 出口, J.Psychiatr. Res., 43: 164-174 (2008)
    The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat
    

13. 山下, J.Cell. Biol., 185: 203-211 (2009)
    A c-Myc-SIRT1 feedback loop regulates cell growth and transformation
    

14. 銭, Genes Dev., 23: 2134-2139 (2009)
    Senescence impairs successful reprogramming to pluripotent stem cells