{"id":1552,"date":"2025-05-08T06:05:23","date_gmt":"2025-05-08T06:05:23","guid":{"rendered":"https:\/\/www.agr.kyushu-u.ac.jp\/cytoplasmicgenomeregulation\/?page_id=1552"},"modified":"2026-04-07T00:35:03","modified_gmt":"2026-04-07T00:35:03","slug":"organization","status":"publish","type":"page","link":"https:\/\/www.agr.kyushu-u.ac.jp\/cytoplasmicgenomeregulation\/organization\/","title":{"rendered":"\u7814\u7a76\u7d44\u7e54"},"content":{"rendered":"\n
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\u7814\u7a76\u5ba4HP<\/mark>\u3000https:\/\/lpmg-u-tokyo.labby.jp<\/a>
Researchmap<\/mark>\u3000https:\/\/researchmap.jp\/ShinichiArimura\/?lang=japanese<\/a>
ORCID<\/mark>\u3000https:\/\/orcid.org\/0000-0002-9537-1626<\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n

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\u7814\u7a76\u5206\u62c5\u8005<\/h3>\n\n\n\n

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\u8a73\u7d30\u3092\u898b\u308b<\/p>\n<\/span><\/div>\n\n\n\n

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\u7814\u7a76\u696d\u7e3e\u3000*\u8cac\u4efb\u8457\u8005<\/span><\/h3>\n\n\n\n
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  1. Nakazato I, Okuno M, Zhou C, Itoh T, Tsutsumi N, Takenaka M, Arimura SI* (2022) Targeted base editing in the mitochondrial genome of Arabidopsis thaliana. Proc Natl Acad Sci USA<\/em><\/strong>, 119: e2121177119.<\/li>\n\n\n\n
  2. Nakazato I, Okuno M, Yamamoto H, Tamura Y, Itoh T, Shikanai T, Takanashi H, Tsutsumi N, Arimura SI* (2021). Targeted base editing in the plastid genome of Arabidopsis thaliana. Nat Plants<\/em><\/strong>, 7: 906\u2013913.<\/li>\n\n\n\n
  3. Arimura SI*, Ayabe H, Sugaya H, Okuno M, Tamura Y, Tsuruta Y, Watari Y, Yanase S, Yamauchi T, Itoh T, Toyoda A, Takanashi H, Tsutsumi N (2020) Targeted gene disruption of ATP synthases 6-1 and 6-2 in the mitochondrial genome of Arabidopsis thaliana by mitoTALENs. Plant J<\/em><\/strong>, 104: 1459\u20131471.<\/li>\n\n\n\n
  4. Kazama T*, Okuno M, Watari Y, Yanase S, Koizuka C, Tsuruta Y, Sugaya H, Toyoda A, Itoh T, Tsutsumi N, Toriyama K, Koizuka N*, Arimura SI* (2019) Curing cytoplasmic male sterility via TALEN-mediated mitochondrial genome editing. Nat Plants<\/em><\/strong>, 5: 722\u2013730.<\/li>\n\n\n\n
  5. Arimura SI*, Fujimoto M, Doniwa Y, Kadoya N, Nakazono M, Sakamoto W, Tsutsumi N (2008) Arabidopsis ELONGATED MITOCHONDRIA1 is required for localization of DYNAMIN-RELATED PROTEIN3A to mitochondrial fission sites. Plant Cell<\/em><\/strong>, 20: 1555\u20131566.<\/li>\n\n\n\n
  6. Arimura SI, Yamamoto J, Aida G, Nakazono M, Tsutsumi N* (2004) Frequent fusion and fission of plant mitochondria with unequal nucleoid distribution. Proc Natl Acad Sci USA<\/em><\/strong>, 101:7805\u20137808.<\/li>\n\n\n\n
  7. Arimura SI, Tsutsumi N* (2002) A dynamin-like protein (ADL2b), rather than FtsZ, is involved in Arabidopsis mitochondrial division. Proc Natl Acad Sci USA<\/em><\/strong>, 99: 5727\u20135731.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n\n\n\n
    <\/div>\n\n\n\n

    A01-2\uff1a\u30aa\u30eb\u30ac\u30cd\u30e9\u3078\u306e\u6838\u9178\u304a\u3088\u3073\u751f\u7406\u6d3b\u6027\u5206\u5b50\u5c0e\u5165<\/strong><\/h3>\n\n\n\n
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    \u6cbc\u7530 \u572d\u53f8<\/h4>\n\n\n\n

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    \u7814\u7a76\u5ba4HP<\/mark>\u3000http:\/\/pixy.polym.kyoto-u.ac.jp\/index.html<\/a>
    Researchmap<\/mark>\u3000    https:\/\/researchmap.jp\/keijinumata_biopoly\/?lang=japanese<\/a>
    ORCID<\/mark>\u3000    https:\/\/orcid.org\/0000-0003-2199-7420<\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n

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    \u7814\u7a76\u5206\u62c5\u8005<\/h3>\n\n\n\n

    \u5c71\u7530\u52c7\u78e8 (\u5317\u6d77\u9053\u5927\u30fb\u85ac\u5b66\u7814\u7a76\u9662\u30fb\u6559\u6388\u30fb\u85ac\u5264\u5206\u5b50\u9001\u9054),
    Simon Law (\u7406\u7814\u30fb\u7814\u7a76\u54e1)<\/p>\n\n\n\n

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    \u5c71\u7530 \u52c7\u9ebf<\/figcaption><\/figure>\n<\/div>\n\n\n\n
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    Simon Law<\/figcaption><\/figure>\n<\/div>\n\n\n\n
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    \u8a73\u7d30\u3092\u898b\u308b<\/p>\n<\/span><\/div>\n\n\n\n

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    \u7814\u7a76\u696d\u7e3e\u3000*\u8cac\u4efb\u8457\u8005<\/span><\/h3>\n\n\n\n
      \n
    1. Miyamoto T*, Tsuchiya K, Toyooka K, Goto Y, Tateishi A, Numata K* (2022) Relaxation of the plant cell wall barrier via zwitterionic liquid pretreatment for micelle complex-mediated DNA delivery to specific plant organelles. Angew Chem Int Ed<\/em><\/strong>, 61: e202204234.<\/li>\n\n\n\n
    2. Law SSY, Liou G, Nagai Y, Gimenez Dejoz J, Tateishi A, Tsuchiya K, Kodama Y, Fujigaya T, Numata K* (2022) Polymer-coated carbon nanotube hybrids with functional peptides for gene delivery into plant mitochondria. Nat Commun<\/em><\/strong>, 13: 2417.<\/li>\n\n\n\n
    3. Thagun C, Horii Y, Mori M, Fujita S, Ohtani M, Tsuchiya K, Kodama Y, Odahara M*, Numata K* (2022) Non-transgenic gene modulation via spray delivery of nucleic acid\/peptide complexes into plant nuclei and chloroplasts. ACS Nano<\/em><\/strong>, 16: 3506\u20133521.<\/li>\n\n\n\n
    4. Miyamoto T, Toyooka K, Chuah J, Odahara M, Higchi-Takeuchi M, Goto Y, Motoda Y, Kigawa T, Kodama Y, Numata K* (2022) Synthetic peptide\u2013guided protein delivery in plants via a distinct endocytic route. JACS Au<\/em><\/strong>, 2: 223\u2013233.<\/li>\n\n\n\n
    5. Thagun C, Chuah J, Numata K* (2019) Targeted gene delivery into various plastids mediated by clustered cell-penetrating and chloroplast-targeting peptides. Adv Sci<\/em><\/strong>, 6: 1902064.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n\n\n\n
      <\/div>\n\n\n\n

      \u516c\u52df\u73ed<\/h2>\n\n\n\n

      A01-3\uff1a\u690d\u7269\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u7279\u7570\u7684\u30a8\u30d4\u30b2\u30ce\u30e0\u7de8\u96c6\u30c4\u30fc\u30eb\u306e\u958b\u767a\u3068\u8a55\u4fa1<\/strong><\/h3>\n\n\n\n
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      \u9577\u90e8 \u8b19\u4e8c<\/h4>\n\n\n\n

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      \u6c96\u7e04\u79d1\u5b66\u6280\u8853\u5927\u5b66\u9662\u5927\u5b66\u30fb\u690d\u7269\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u30e6\u30cb\u30c3\u30c8\u3000\u30b0\u30eb\u30fc\u30d7\u30ea\u30fc\u30c0\u30fc
      \u7814\u7a76\u5ba4HP<\/mark>\u3000https:\/\/www.oist.jp\/ja\/research\/research-units\/peu<\/a>
      Researchmap<\/mark>\u3000      https:\/\/researchmap.jp\/kenjiosabe<\/a>
      ORCID<\/mark>\u3000      https:\/\/orcid.org\/0000-0002-5216-1055<\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n

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      \u8a73\u7d30\u3092\u898b\u308b<\/p>\n<\/span><\/div>\n\n\n\n

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      \u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306f\u690d\u7269\u306b\u304a\u3051\u308b\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u3084\u6210\u9577\u3001\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u306b\u91cd\u8981\u3067\u3042\u308a\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA\uff08mtDNA\uff09\u306e\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u3001\u7279\u306bDNA\u30e1\u30c1\u30eb\u5316\u306e\u5f79\u5272\u306f\u672a\u89e3\u660e\u3067\u3042\u308b\u3002\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u5236\u5fa1\u306f\u6838\u30b2\u30ce\u30e0\u306b\u304a\u3051\u308b\u907a\u4f1d\u5b50\u767a\u73fe\u8abf\u7bc0\u306b\u5e83\u304f\u95a2\u4e0e\u3057\u3001DNA\u30e1\u30c1\u30eb\u5316\u9175\u7d20\u306b\u3088\u308b\u7279\u5b9a\u306e\u30e1\u30c1\u30eb\u5316\u30d1\u30bf\u30fc\u30f3\uff08CG\u3001CHG\u3084CHH\u3001H\uff1dA\u3001C\u3001T\uff09\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u304c\u3001\u690d\u7269\u306b\u304a\u3051\u308bmtDNA\u306e\u30e1\u30c1\u30eb\u5316\u3084\u305d\u306e\u6a5f\u80fd\u306b\u3064\u3044\u3066\u306e\u5831\u544a\u306f\u9650\u3089\u308c\u3066\u3044\u308b\u3002\u6838\u5185\u306eDNA\u30e1\u30c1\u30eb\u5316\u306fDNA\u3068\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u76f8\u4e92\u4f5c\u7528\u3001\u30b2\u30ce\u30e0\u306e\u7acb\u4f53\u69cb\u9020\u306a\u3069\u306b\u5f71\u97ff\u3059\u308b\u3053\u3068\u3067\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u5236\u5fa1\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\u3001mtDNA\u306e\u30e1\u30c1\u30eb\u5316\u3082\u907a\u4f1d\u5b50\u767a\u73fe\u306b\u5f71\u97ff\u3059\u308b\u3053\u3068\u304c\u8003\u3048\u3089\u308c\u308b\u3002\u672c\u7814\u7a76\u3067\u306f\u3001\u690d\u7269\u7d30\u80de\u8cea\u30b2\u30ce\u30e0\u7de8\u96c6\u6280\u8853\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\uff081\uff09\u690d\u7269\u306emtDNA\u306b\u914d\u5217\u7279\u7570\u7684\u306a\u30e1\u30c1\u30eb\u5316\u3092\u8a98\u5c0e\u3059\u308b\u6280\u8853\u3092\u958b\u767a\u3057\u3001\uff082\uff09mtDNA\u30e1\u30c1\u30eb\u5316\u306e\u4e16\u4ee3\u9593\u7d99\u627f\u306e\u89e3\u6790\u3001\uff083\uff09mtDNA\u306e\u30e1\u30c1\u30eb\u5316\u5909\u5316\u304c\u690d\u7269\u306e\u6210\u9577\u3084\u5f62\u8cea\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u306e\u8a55\u4fa1\u306b\u53d6\u308a\u7d44\u3080\u3002
      <\/p>\n\n\n\n

      \"\"<\/figure>\n\n\n\n

      \u7814\u7a76\u696d\u7e3e\u3000*\u8cac\u4efb\u8457\u8005<\/span><\/h3>\n\n\n\n
        \n
      1. Akter MA, Mehraj H, Miyaji N, Takahashi S, Takasaki-Yasuda T, Seki M, Dennis ES, Fujimoto R, Osabe K* (2022). Transcriptional Association between mRNAs and Their Paired Natural Antisense Transcripts Following Fusarium oxysporum Inoculation in Brassica rapa L. Horticulturae<\/strong><\/em> 8(1): 17<\/li>\n\n\n\n
      2. Mehraj H, Shea DJ, Takahashi S, Miyaji N, Akter A, Seki M, Dennis ES, Fujimoto R, Osabe K* (2021). Genome-wide analysis of long noncoding RNAs, 24-nt siRNAs, DNA methylation and H3K27me3 marks in Brassica rapa. Plos One<\/em><\/strong> 16(3): e0242530<\/li>\n\n\n\n
      3. Osabe K, Harukawa Y, Miura S, Saze H* (2017). Epigenetic regulation of intronic transgenes in Arabidopsis. Scientific Reports<\/em><\/strong> 7: 45166<\/li>\n<\/ol>\n<\/div>\n<\/div>\n\n\n\n
        <\/div>\n\n\n\n

        B01\u3000\u907a\u4f1d\u7406\u89e3<\/p>\n\n\n\n

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        B01-1\uff1a\u690d\u7269\u7d30\u80de\u8cea\u30b2\u30ce\u30e0\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u5236\u5fa1\u6a5f\u69cb\u306e\u89e3\u660e<\/strong><\/strong><\/h3>\n\n\n\n
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        \u4eac\u90fd\u5927\u5b66\u7406\u5b66\u7814\u7a76\u79d1\u3000\u51c6\u6559\u6388
        \u7814\u7a76\u5ba4HP<\/mark>\u3000https:\/\/sites.google.com\/site\/mizukitakenakajapanese<\/a>
        Researchmap<\/mark>\u3000        https:\/\/researchmap.jp\/7000021262?lang=japanese<\/a>
        ORCID<\/mark>\u3000        https:\/\/orcid.org\/0000-0002-3242-5092<\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n

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        \u8a73\u7d30\u3092\u898b\u308b<\/p>\n<\/span><\/div>\n\n\n\n

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        \u690d\u7269\u7d30\u80de\u8cea\u30b2\u30ce\u30e0\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u306f\u5668\u5b98\u3084\u767a\u80b2\u3001\u74b0\u5883\u72b6\u6cc1\u306a\u3069\u306b\u5fdc\u3058\u3066\u5236\u5fa1\u3055\u308c\u308b\u3002\u305d\u306e\u5236\u5fa1\u6a5f\u69cb\u306f\u5f53\u521d\u8003\u3048\u3089\u308c\u3066\u3044\u305f\u3088\u308a\u9065\u304b\u306b\u8907\u96d1\u3067\u3042\u308a\u3001\u3053\u308c\u307e\u3067\u591a\u6570\u306e\u6838\u30b3\u30fc\u30c9\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u3001\u8ee2\u5199\u3084RNA\u5207\u65ad\u3001 RNA\u7de8\u96c6\u3001\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u3001\u7ffb\u8a33\u3001RNA\u5206\u89e3\u306a\u3069\u306e\u5236\u5fa1\u56e0\u5b50\u3068\u3057\u3066\u540c\u5b9a\u3055\u308c\u3066\u304d\u305f\u3002\u3057\u304b\u3057\u3001\u3053\u308c\u3089\u304c\u9023\u52d5\u3057\u3066\u50cd\u304f\u7d71\u5408\u7684\u5236\u5fa1\u6a5f\u69cb\u306b\u3064\u3044\u3066\u306f\u307b\u3068\u3093\u3069\u672a\u89e3\u660e\u3067\u3042\u308b\u3002\u672c\u7814\u7a76\u3067\u306f\u8907\u6570\u306e\u5206\u5b50\u304c\u9023\u52d5\u3059\u308b\u30c0\u30a4\u30ca\u30df\u30c3\u30af\u306a\u30aa\u30eb\u30ac\u30cd\u30e9\u907a\u4f1d\u5b50\u767a\u73fe\u5236\u5fa1\u6a5f\u69cb\u306e\u7406\u89e3\u3092\u76ee\u6307\u3059\u3002\u305d\u306e\u305f\u3081\u306b\u306f\u5404\u5236\u5fa1\u56e0\u5b50\u3068\u30b2\u30ce\u30e0DNA\u3084RNA\u3068\u306e\u95a2\u4fc2\u6027\u3092\u89e3\u660e\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002\u2460\u6709\u6751\u73ed\u3001\u77e2\u5b88\u73ed\u3068\u5354\u50cd\u3057\u3001\u7d30\u80de\u8cea\u30b2\u30ce\u30e0\u306e\u30e9\u30f3\u30c0\u30e0\u5869\u57fa\u7f6e\u63db\u5909\u7570\u4f53\u304b\u3089\u907a\u4f1d\u5b50\u5236\u5fa1\u6a5f\u69cb\u5909\u7570\u4f53\u306e\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3092\u884c\u3044\u3001DNA\u3001RNA\u914d\u5217\u3068\u907a\u4f1d\u5b50\u767a\u73fe\u5236\u5fa1\u3068\u306e\u95a2\u4fc2\u6027\u3092\u89e3\u660e\u3059\u308b\u3002\u2461\u6709\u6751\u73ed\u3068\u5354\u529b\u3057\u3001\u30aa\u30eb\u30ac\u30cd\u30e9\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u958b\u59cb\u70b9\u4ed8\u8fd1\u306b\u5909\u7570\u3092\u5c0e\u5165\u3057\u3001\u3053\u308c\u307e\u3067\u6280\u8853\u7684\u306b\u56f0\u96e3\u3067\u3042\u3063\u305f\u8a73\u7d30\u306a\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u89e3\u6790\u3092\u884c\u3046\u3002\u2462\u307e\u305f\u5404C-to-U RNA\u7de8\u96c6\u30b5\u30a4\u30c8\u3092DNA\u306e\u6bb5\u968e\u3067T\u306b\u5909\u63db\u3057\u3001\u305d\u306e\u5f71\u97ff\u3092\u8a73\u7d30\u306b\u89e3\u6790\u3059\u308b\u3053\u3068\u3067RNA\u7de8\u96c6\u304c\u907a\u4f1d\u5b50\u767a\u73fe\u5236\u5fa1\u6a5f\u69cb\u3068\u3057\u3066\u5b58\u5728\u3059\u308b\u751f\u7269\u5b66\u7684\u610f\u7fa9\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3002\u2463\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u9593\u3067\u306e\u60c5\u5831\u540c\u671f\u306f\u3001\u8907\u6570\u5b58\u5728\u3059\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u30b2\u30ce\u30e0\u907a\u4f1d\u5b50\u306e\u7d71\u5fa1\u7684\u306a\u767a\u73fe\u5236\u5fa1\u306b\u5fc5\u9808\u3067\u3042\u308b\u3002\u6709\u6751\u73ed\u3001\u77f3\u539f\u73ed\u3001\u897f\u6751\u73ed\u3068\u5354\u529b\u3057\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u878d\u5408\u30fb\u5206\u88c2\u3084\u6838\u69d8\u4f53\u306e\u5f62\u6210\u30fb\u5206\u914d\u306e\u7570\u5e38\u304c\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u30b2\u30ce\u30e0\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u5236\u5fa1\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u3092\u89e3\u6790\u3059\u308b\u3002\u4ee5\u4e0a\u306e\u3088\u3046\u306a\u89e3\u6790\u304b\u3089\u3001\u7d30\u80de\u8cea\u30b2\u30ce\u30e0\u3068\u305d\u308c\u304c\u62c5\u3046\u751f\u547d\u73fe\u8c61\u3092\u7e4b\u3052\u308b\u91cd\u8981\u306a\u30d1\u30a4\u30d7\u306e\u4e00\u3064\u3067\u3042\u308b\u907a\u4f1d\u5b50\u767a\u73fe\u5236\u5fa1\u6a5f\u69cb\u306e\u7406\u89e3\u3092\u76ee\u6307\u3059\u3053\u3068\u3067\u672c\u9818\u57df\u306b\u8ca2\u732e\u3059\u308b\u3002<\/p>\n\n\n\n

        \"\"<\/figure>\n\n\n\n

        \u7814\u7a76\u696d\u7e3e\u3000*\u8cac\u4efb\u8457\u8005<\/span><\/h3>\n\n\n\n
          \n
        1. Takenaka M*, Takenaka S, Barthel T, Frink B, Haag S, Verbitskiy D, Oldenkott B, Schallenberg-R\u00fcdinger M, Feiler CG, Weiss MS, Palm GJ, Weber G (2021) DYW domain structures imply an unusual regulation principle in plant organellar RNA editing catalysis. Nat Catal<\/em><\/strong>, 4: 510\u2013522.<\/li>\n\n\n\n
        2. Guillaumot D, Lopez-Obando M, Baudry K, Avon A, Rigaill G, Falcon de Longevialle A, Broche B, Takenaka M, Berthom\u00e9 R, De Jaeger G, Delannoy E, Lurin C* (2017) Two interacting PPR proteins are major Arabidopsis editing factors in plastid and mitochondria. Proc Natl Acad Sci USA<\/em><\/strong>, 114: 8877\u20138882.<\/li>\n\n\n\n
        3. Takenaka M*, Zehrmann A, Verbitskiy D, Kugelmann M, H\u00e4rtel B, Brennicke A (2012) Multiple organellar RNA editing factor (MORF) family proteins are required for RNA editing in mitochondria and plastids of plants. Proc Natl Acad Sci USA<\/em><\/strong>, 109: 5104\u20135109.<\/li>\n\n\n\n
        4. Zehrmann A, Verbitskiy D, van der Merwe JA, Brennicke A, Takenaka M* (2009) A DYW domaincontaining pentatricopeptide repeat protein is required for RNA editing at multiple sites in mitochondria of Arabidopsis thaliana. Plant Cell<\/em><\/strong>, 21: 558\u2013567.<\/li>\n\n\n\n
        5. Takenaka M*, Brennicke A (2009) Multiplex single-base extension typing to identify nuclear genes required for RNA editing in plant organelles. Nucl Acids Res<\/em><\/strong>, 37: e13.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n\n\n\n
          <\/div>\n\n\n\n

          B01-2\uff1a\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u30b2\u30ce\u30e0\u306e\u6bcd\u6027\u907a\u4f1d\u30fb\u52d5\u614b\u30fb\u54c1\u8cea\u7ba1\u7406\u6a5f\u69cb\u306e\u89e3\u660e<\/strong><\/strong><\/strong><\/h3>\n\n\n\n
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          \u7814\u7a76\u5ba4HP<\/mark>\u3000http:\/\/makukinou.showa.gunma-u.ac.jp\/index.html<\/a>
          Researchmap<\/mark>\u3000          https:\/\/researchmap.jp\/read0153917\/?lang=japanese<\/a>
          ORCID<\/mark>\u3000          https:\/\/orcid.org\/0000-0002-1944-4918<\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n

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          \u8a73\u7d30\u3092\u898b\u308b<\/p>\n<\/span><\/div>\n\n\n\n

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          \u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u30b2\u30ce\u30e0\u306f\u3001\u300c\u6bcd\u6027\u907a\u4f1d\u3059\u308b\u3053\u3068\u300d\u3084\u300c\u30d8\u30c6\u30ed\u30d7\u30e9\u30b9\u30df\u30fc (\u7d30\u80de\u5185\u591a\u7a2emtDNA \u6df7\u5728\u72b6\u614b) \u3067\u5b58\u5728\u3067\u304d\u308b\u3053\u3068\u300d\u306a\u3069\u3001\u6838\u30b2\u30ce\u30e0\u3068\u306f\u7570\u306a\u308b\u7279\u6709\u306e\u6027\u8cea\u3092\u6301\u3064\u3002\u3053\u308c\u3089\u306e\u7279\u6027\u306f\u6cbb\u7642\u6cd5\u304c\u78ba\u7acb\u3057\u3066\u3044\u306a\u3044\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u75c5\u3092\u7406\u89e3\u3059\u308b\u305f\u3081\u306e\u57fa\u672c\u6982\u5ff5\u3067\u3042\u308b\u306b\u3082\u95a2\u308f\u3089\u305a\u3001\u305d\u306e\u5206\u5b50\u57fa\u76e4\u3084\u751f\u7406\u7684\u610f\u7fa9\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u30b2\u30ce\u30e0\u7814\u7a76\u306e\u672a\u89e3\u660e\u554f\u984c\u3067\u3042\u308b\u3002\u672c\u7814\u7a76\u73ed\u306f\u591a\u5f69\u306a\u30e2\u30c7\u30eb\u7cfb (\u7dda\u866b\u3001\u30de\u30a6\u30b9\u3001 \u54fa\u4e73\u985e\u57f9\u990a\u7d30\u80de\u3001 \u9175\u6bcd) \u3092\u7528\u3044\u3066\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u54c1\u8cea\u7ba1\u7406\u6a5f\u69cb\u3067\u3042\u308b\u30de\u30a4\u30c8\u30d5\u30a1\u30b8\u30fc\u3092\u8d77\u70b9\u306b\u4ee5\u4e0b\u306e\u554f\u984c\u89e3\u660e\u3092\u76ee\u6307\u3059\u3002\u2460\u7236\u6027\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u7279\u7570\u7684\u30de\u30a4\u30c8\u30d5\u30a1\u30b8\u30fc\u3092\u4e2d\u5fc3\u3068\u3057\u305f\u6bcd\u6027\u907a\u4f1d\u306e\u5206\u5b50\u6a5f\u69cb\u3068\u751f\u7406\u7684\u610f\u7fa9\u306e\u89e3\u660e\u3001\u2461\u751f\u6b96\u7d30\u80de\u5206\u5316\u904e\u7a0b\u306b\u304a\u3044\u3066\u7cbe\u5b50\u30fb\u5375\u5b50\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u9055\u3044\u3092\u751f\u307f\u51fa\u3059\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\u3001\u2462\u30d8\u30c6\u30ed\u30d7\u30e9\u30b9\u30df\u30fc\u3092\u7dad\u6301\u3059\u308b\u6a5f\u69cb\u306e\u89e3\u660e\u3068\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u3078\u306e\u5f71\u97ff\u306e\u89e3\u6790\u3001\u2463\u30de\u30a4\u30c8\u30d5\u30a1\u30b8\u30fc\u306b\u3088\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u30b2\u30ce\u30e0\u54c1\u8cea\u7ba1\u7406\u6a5f\u69cb\u306e\u7406\u89e3\u3068\u305d\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u75c5\u30e2\u30c7\u30eb\u751f\u7269\u3078\u306e\u5fdc\u7528\u3002\u3053\u308c\u3089\u306e\u8ab2\u984c\u3092\u9054\u6210\u3059\u308b\u305f\u3081\u3001A01 \u73ed\u304c\u958b\u767a\u3059\u308b\u6280\u8853\u3092\u7528\u3044\u3066\u52d5\u7269\u500b\u4f53 (\u7dda\u866b\u3084\u30de\u30a6\u30b9) \u3067\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u30b2\u30ce\u30e0\u7de8\u96c6\u3092\u884c\u3044\u3001\u96cc\u96c4\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u30b2\u30ce\u30e0\u3092\u7c21\u4fbf\u306b\u898b\u5206\u3051\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u5b9f\u9a13\u7cfb\u3084\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u75c5\u30e2\u30c7\u30eb\u751f\u7269\u3092\u69cb\u7bc9\u3057\u3001\u7814\u7a76\u3092\u63a8\u9032\u3059\u308b\u3002\u307e\u305f\u3001\u3053\u308c\u3089\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u30b2\u30ce\u30e0\u7279\u6709\u306e\u6319\u52d5\u30fb\u907a\u4f1d\u69d8\u5f0f\u306b\u95a2\u3057\u3066\u5f97\u3089\u308c\u305f\u77e5\u898b\u3092A01\u73ed\u306b\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u3059\u308b\u3053\u3068\u3067\u3001\u7d30\u80de\u8cea\u30b2\u30ce\u30e0\u5236\u5fa1\u6cd5\u306e\u3055\u3089\u306a\u308b\u767a\u5c55\u306b\u8ca2\u732e\u3059\u308b\u3002<\/p>\n\n\n\n

          \"\"<\/figure>\n\n\n\n

          \u7814\u7a76\u696d\u7e3e\u3000*\u8cac\u4efb\u8457\u8005<\/span><\/code><\/h3>\n\n\n\n
            \n
          1. Sato M*, Sato K, Tomura K, Kosako H, Sato K* (2018) The autophagy receptor ALLO-1 and the IKKE-1 kinase control clearance of paternal mitochondria in Caenorhabditis elegans. Nat Cell Biol<\/em><\/strong>, 20: 81\u201391.<\/li>\n\n\n\n
          2. Saegusa K, Sato M*, Morooka N, Hara T, Sato K* (2018) SFT-4\/Surf4 control ER export of soluble cargo proteins and participate in ER exit site organization. J Cell Biol<\/em><\/strong>, 217: 2073\u20132085.<\/li>\n\n\n\n
          3. Sakaguchi A, Sato M (co-first author), Sato K, Gengyo-Ando K, Yorimitsu T, Nakai J, Hara T, Sato K, Sato K* (2015) REI-1 is a guanine nucleotide exchange factor regulating RAB-11 localization and function in C. elegans<\/em> embryos. Dev Cell<\/em><\/strong>, 35: 211\u2013221.<\/li>\n\n\n\n
          4. Sato M*, Konuma R, Sato K, Tomura K, Sato K* (2015) Fertilization-induced K63-linked ubiquitylation mediates clearance of maternal membrane proteins. Development<\/em><\/strong>, 141: 1324\u20131331.<\/li>\n\n\n\n
          5. Sato M, Sato K* (2011) Degradation of paternal mitochondria by fertilization-triggered autophagy in C. elegans<\/em> embryos. Science<\/em><\/strong>, 334: 1141\u20131144.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n\n\n\n
            <\/div>\n\n\n\n

            B01-3\uff1aChloroTALEN\u3067\u5fa1\u3059\u308b\u7d30\u80de\u8cea\u30b2\u30ce\u30e0\/\u8449\u7dd1\u4f53\u6838\u69d8\u4f53\u306e\u52d5\u614b\u30fb\u4fee\u5fa9\u30fb\u6bcd\u6027\u907a\u4f1d<\/strong><\/strong><\/strong><\/strong><\/h3>\n\n\n\n
            \n
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            \"\"<\/figure>\n<\/div>\n\n\n\n
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            <\/div><\/div>\n\n\n\n

            \u897f\u6751 \u82b3\u6a39<\/h4>\n\n\n\n

            \u7814\u7a76\u4ee3\u8868\u8005
            \u65e9\u7a32\u7530\u5927\u5b66\u5148\u7aef\u751f\u547d\u533b\u79d1\u5b66\u30bb\u30f3\u30bf\u30fc\u3000\u51c6\u6559\u6388
            \u7814\u7a76\u5ba4HP<\/mark>\u3000https:\/\/sites.google.com\/view\/chlamywaseda\/home?authuser=0<\/a>
            Researchmap<\/mark>\u3000            https:\/\/researchmap.jp\/7000008742\/?lang=japanese<\/a>
            ORCID<\/mark>\u3000            https:\/\/orcid.org\/0000-0001-8686-9206<\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n

            \n
            \n

            \u8a73\u7d30\u3092\u898b\u308b<\/p>\n<\/span><\/div>\n\n\n\n

            \n

            \u8449\u7dd1\u4f53\u79fb\u884c\u578bTALEN (chloroTALEN) \u3068\u8449\u7dd1\u4f53\u6838\u69d8\u4f53\u306e\u30e9\u30a4\u30d6\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u6280\u8853\u3092\u57fa\u76e4\u3068\u3057\u3001\u8449\u7dd1\u4f53\u6838\u69d8\u4f53\u306e\u7d30\u80de\u8cea\u30b2\u30ce\u30e0\u4fee\u5fa9\u904e\u7a0b\u306b\u304a\u3051\u308b\u52d5\u614b\u3001\u304a\u3088\u3073\u6bcd\u6027\u907a\u4f1d\u306e\u5236\u5fa1\u6a5f\u69cb\u306b\u8feb\u308b\u3002\u2460\u8449\u7dd1\u4f53DNA\u4fee\u5fa9\u306e\u6642\u7a7a\u9593\u7684\u89e3\u6790: \u690d\u7269\u306e\u5149\u5408\u6210\u306e\u8981\u3067\u3042\u308b\u8449\u7dd1\u4f53\u306b\u306f\u3001\u72ec\u81ea\u306eDNA (\u8449\u7dd1\u4f53DNA) \u304a\u3088\u3073\u305d\u306e\u8907\u88fd\u30fb\u907a\u4f1d\u5b50\u767a\u73fe\u6a5f\u69cb\u304c\u5099\u308f\u3063\u3066\u3044\u308b\u3002\u8449\u7dd1\u4f53DNA\u306b\u306f\u5149\u5408\u6210\u3084\u8449\u7dd1\u4f53\u306e\u6a5f\u80fd\u7dad\u6301\u306b\u5fc5\u9808\u306a\u907a\u4f1d\u5b50\u7fa4\u304c\u30b3\u30fc\u30c9\u3055\u308c\u3066\u304a\u308a\u3001\u305d\u306e\u4fee\u5fa9\u3084\u5b89\u5b9a\u306a\u907a\u4f1d\u306f\u690d\u7269\u306b\u3068\u3063\u3066\u6b7b\u6d3b\u554f\u984c\u3067\u3042\u308b\u304c\u3001\u305d\u306e\u5b9f\u614b\u306f\u5341\u5206\u7406\u89e3\u3055\u308c\u3066\u3044\u306a\u3044\u3002\u305d\u3053\u3067\u672c\u7814\u7a76\u3067\u306f\u3001\u6709\u6751\u73ed\u306e\u5354\u529b\u306e\u3082\u3068\u3001\u30e2\u30c7\u30eb\u7dd1\u85fb\u30af\u30e9\u30df\u30c9\u30e2\u30ca\u30b9\u306b\u304a\u3044\u3066\u8449\u7dd1\u4f53DNA\u306bdouble strand break (DSB) \u3092\u5c0e\u5165\u3059\u308b\u8449\u7dd1\u4f53\u79fb\u884c\u578bTALEN(chloroTALEN) \u3092\u958b\u767a\u3057\u3001\u767a\u73fe\u8a98\u5c0e\u3059\u308b\u3053\u3068\u3067\u3001\u305d\u308c\u306b\u5fdc\u7b54\u3057\u305f\u8449\u7dd1\u4f53DNA\u4fee\u5fa9\u56e0\u5b50\u7fa4\u306e\u6319\u52d5\u3092\u30e9\u30a4\u30d6\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3067\u6349\u3048\u3001\u8449\u7dd1\u4f53DNA\u4fee\u5fa9\u7cfb\u306e\u6642\u7a7a\u9593\u7684\u306a\u7406\u89e3\u3092\u76ee\u6307\u3059\u3002\u2461\u8449\u7dd1\u4f53\u6bcd\u6027\u907a\u4f1d\u306e\u4eba\u70ba\u7684\u5236\u5fa1\u6280\u8853\u958b\u767a: \u7dd1\u85fb\u30af\u30e9\u30df\u30c9\u30e2\u30ca\u30b9\u3067\u306f\u3001 \u8449\u7dd1\u4f53DNA\u306f\u6bcd\u6027\u907a\u4f1d\u3059\u308b\u3002chloroTALEN\u3092\u63a5\u5408\u5b50\u306e\u96cc\u3067\u767a\u73fe\u3055\u305b\u3001\u6bcd\u89aa\u306e\u8449\u7dd1\u4f53DNA\u3092\u65ad\u7247\u5316\u3059\u308b\u3053\u3068\u3067\u3001\u6bcd\u6027\u907a\u4f1d\u3092\u7236\u6027\u907a\u4f1d\u3078\u3068\u4eba\u5de5\u7684\u306b\u5909\u63db\u30fb\u5236\u5fa1\u3059\u308b\u3053\u3068\u306b\u6311\u6226\u3059\u308b\u3002\u3055\u3089\u306b\u7236\u6027\u907a\u4f1d\u304c\u4fc3\u9032\u3055\u308c\u308b\u5909\u7570\u4f53\u3092\u9078\u629c\u3057\u3001\u305d\u306e\u539f\u56e0\u907a\u4f1d\u5b50\u540c\u5b9a\u3092\u304a\u3053\u306a\u3046\u3053\u3068\u3067\u3001\u6bcd\u6027\u907a\u4f1d\u306e\u5206\u5b50\u6a5f\u69cb\u306b\u8feb\u308b\u3002\u2462\u672c\u7814\u7a76\u3067\u78ba\u7acb\u3055\u308c\u305f\u6280\u8853\u3001\u304a\u3088\u3073\u5f97\u3089\u308c\u305f\u77e5\u898b\u3092\u4f50\u85e4\u73ed\u3001\u6709\u6751\u73ed\u3001\u7af9\u4e2d\u73ed\u306e\u5354\u529b\u306e\u3082\u3068\u3001\u52d5\u7269\u3084\u9678\u4e0a\u690d\u7269\u3078\u3068\u5fdc\u7528\u5c55\u958b\u3057\u3001\u771f\u6838\u751f\u7269\u5168\u4f53\u306b\u304a\u3051\u308b\u7d30\u80de\u8cea\u30b2\u30ce\u30e0\u4fee\u5fa9\u3001\u6bcd\u6027\u907a\u4f1d\u6a5f\u69cb\u306e\u7406\u89e3\u3092\u76ee\u6307\u3059\u3053\u3068\u3067\u672c\u9818\u57df\u306e\u9032\u5c55\u306b\u8ca2\u732e\u3059\u308b\u3002<\/p>\n\n\n\n

            \"\"<\/figure>\n\n\n\n

            \u7814\u7a76\u696d\u7e3e\u3000*\u8cac\u4efb\u8457\u8005<\/span><\/h3>\n\n\n\n
              \n
            1. Takusagawa M, Kobayashi Y, Fukao Y, Hidaka K, Endo M, Sugiyama H, Hamaji T, Kato Y, Miyakawa I, Misumi O, Shikanai T, Nishimura Y* (2021) HBD1 protein with a tandem repeat of two HMG box domains is a DNA clip to organize chloroplast nucleoids in Chlamydomonas reinhardtii. Proc Natl Acad Sci USA<\/em><\/strong>, 118:1\u20138.<\/li>\n\n\n\n
            2. Kamimura Y, Tanaka H, Kobayashi Y, Shikanai T, Nishimura Y* (2018) Chloroplast nucleoids as a transformable network revealed by live imaging with a micro fluidic device. Commun Biol<\/em><\/strong>, 1: 1\u20137.<\/li>\n\n\n\n
            3. Kobayashi Y, Misumi O, Odahara M, Ishibashi K, Hirono M, Hidaka K, Endo M, Sugiyama H, Iwasaki H, Kuroiwa T, Shikanai T, Nishimura Y* (2017) Holliday junction resolvases mediate chloroplast nucleoid segregation. Science<\/em><\/strong>, 356: 631\u2013634.<\/li>\n\n\n\n
            4. Nishimura Y*, Shikanai T, Nakamura S, Kawai-Yamada M, Uchimiya H (2012) Gsp1 triggers the sexual developmental program including inheritance of chloroplast DNA and mitochondrial DNA in Chlamydomonas reinhardtii. Plant Cell<\/em><\/strong>, 24: 2401\u20132414.<\/li>\n\n\n\n
            5. Nishimura Y*, Misumi O, Matsunaga S, Higashiyama T, Yokota A, Kuroiwa T (1999) The active digestion of uniparental chloroplast DNA in a single zygote of Chlamydomonas reinhardtii is revealed by using the optical tweezer. Proc Natl Acad Sci USA<\/em><\/strong>, 96: 12577\u201312582.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n\n\n\n
              <\/div>\n\n\n\n

              \u516c\u52df\u73ed<\/h2>\n\n\n\n

              B01-4\uff1a\u8449\u7dd1\u4f53\u6838\u69d8\u4f53\u69cb\u9020\u306e\u6027\u5dee\u306e\u767a\u898b\u306b\u57fa\u3065\u304f\u8449\u7dd1\u4f53\u6bcd\u6027\u907a\u4f1d\u6a5f\u69cb\u306e\u89e3\u6790<\/strong><\/strong><\/strong><\/strong><\/h3>\n\n\n\n
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              \"\"<\/figure>\n<\/div>\n\n\n\n
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              <\/div><\/div>\n\n\n\n

              \u5c0f\u6797 \u512a\u4ecb<\/h4>\n\n\n\n

              \u7814\u7a76\u4ee3\u8868\u8005
              \u8328\u57ce\u5927\u5b66\u30fb\u57fa\u790e\u81ea\u7136\u79d1\u5b66\u91ce\u3000\u51c6\u6559\u6388
              Researchmap<\/mark>\u3000https:\/\/researchmap.jp\/yusuke2828<\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n

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              \u8a73\u7d30\u3092\u898b\u308b<\/p>\n<\/span><\/div>\n\n\n\n

              \n

              \u5358\u7d30\u80de\u6027\u7dd1\u85fb\u30af\u30e9\u30df\u30c9\u30e2\u30ca\u30b9\u306f\u4e00\u5bfe\u306e\u6027\u3092\u6709\u3059\u308b\u3002\u74b0\u5883\u304c\u826f\u597d\u306a\u5834\u5408\u3001\u30af\u30e9\u30df\u30c9\u30e2\u30ca\u30b9\u306f\u7121\u6027\u751f\u6b96\u3067\u5897\u6b96\u3059\u308b\u304c\u3001\u5f37\u5149\u3068\u7a92\u7d20\u98e2\u9913\u306b\u66dd\u3055\u308c\u308b\u3068\u3001\u4e21\u6027\u3067\u540c\u3058\u5927\u304d\u3055\u306e\u914d\u5076\u5b50\uff08\u540c\u578b\u914d\u5076\u5b50\uff09\u306b\u5206\u5316\u3057\u3001\u6709\u6027\u751f\u6b96\u3092\u958b\u59cb\u3059\u308b\u3002\u540c\u578b\u914d\u5076\u5b50\u306e\u751f\u6b96\u306e\u5834\u5408\u3001\u63a5\u5408\u5b50\u306b\u306f\u4e21\u89aa\u304b\u3089\u7b49\u91cf\u306e\u8449\u7dd1\u4f53DNA\u304c\u6301\u3061\u8fbc\u307e\u308c\u308b\u304c\u3001\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u3001\u6b21\u4e16\u4ee3\u306b\u306f\u8449\u7dd1\u4f53DNA\u304c\u7247\u89aa\uff08\u6bcd\u6027\uff09\u907a\u4f1d\u3059\u308b\u3002\u30af\u30e9\u30df\u30c9\u30e2\u30ca\u30b9\u306b\u304a\u3051\u308b\u8449\u7dd1\u4f53DNA\u306e\u6bcd\u6027\u907a\u4f1d\u306f\u3001\u63a5\u5408\u5b50\u5f62\u6210\u76f4\u5f8c\u306b\u7236\u6027\u306e\u8449\u7dd1\u4f53DNA\u304c\u9078\u629e\u7684\u306b\u5206\u89e3\u3055\u308c\u308b\u3053\u3068\u304c\u539f\u52d5\u529b\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u304c\u3001\u305d\u306e\u9078\u629e\u7684\u5206\u89e3\u6a5f\u69cb\u306f\u4e0d\u660e\u3067\u3042\u308b\u3002\u3053\u308c\u307e\u3067\u306b\u79c1\u305f\u3061\u306f\u3001\u63a5\u5408\u5b50\u306b\u304a\u3044\u3066\u7236\u6027\u307e\u305f\u306f\u6bcd\u6027\u7531\u6765\u306e\u8449\u7dd1\u4f53DNA\u306b\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u7d44\u6210\u304c\u7570\u306a\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u305f\u3002\u672c\u7814\u7a76\u3067\u306f\u3001\u3053\u306e\u8449\u7dd1\u4f53\u6838\u69d8\u4f53\u69cb\u9020\u306e\u6027\u5dee\u306b\u7740\u76ee\u3057\u3001\u7236\u6027\u8449\u7dd1\u4f53DNA\u306e\u9078\u629e\u7684\u5206\u89e3\u3092\u62c5\u3046\u56e0\u5b50\u306e\u540c\u5b9a\u3068\u3001\u6bcd\u6027\u8449\u7dd1\u4f53DNA\u306e\u4fdd\u8b77\u6a5f\u69cb\u306e\u89e3\u660e\u3092\u76ee\u6307\u3059\u3002<\/p>\n\n\n\n

              \"\"<\/figure>\n\n\n\n

              \u7814\u7a76\u696d\u7e3e\u3000*\u8cac\u4efb\u8457\u8005<\/span><\/h3>\n\n\n\n
                \n
              1. Kobayashi Y*, Odahara M, Sekine Y, Hamaji T, Fujiwara S, Nishimura Y, Miyagishima SY (2020) Holliday Junction Resolvase MOC1 Maintains Plastid and Mitochondrial Genome Integrity in Algae and Bryophytes. Plant Physiology<\/em><\/strong>, 184: 1870\u20131883<\/li>\n\n\n\n
              2. Kobayashi Y, Misumi O, Odahara M, Ishibashi K, Hirono M, Hidaka K, Endo M, Sugiyama H, Iwasaki H, Kuroiwa T, Shikanai T, Nishimura Y* (2017) Holliday junction resolvases mediate chloroplast nucleoid segregation. Science<\/em><\/strong>, 356: 631\u2013634.<\/li>\n\n\n\n
              3. Kobayashi Y, Takusagawa M, Harada N, Fukao Y, Yamaoka S, Kohchi T, Hori K, Ohta H, Shikanai T, Nishimura Y* (2016) Eukaryotic Components Remodeled Chloroplast Nucleoid Organization during the Green Plant Evolution. Genome Biology and Evolution<\/em><\/strong>, 8: 1-16.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n\n\n\n
                <\/div>\n\n\n\n

                B01-5\uff1amicroRNA\u304c\u8449\u7dd1\u4f53\u6bcd\u6027\u907a\u4f1d\u306e\u53b3\u5bc6\u6027\u3092\u7dad\u6301\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e<\/strong><\/strong><\/strong><\/strong><\/h3>\n\n\n\n
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                \"\"<\/figure>\n<\/div>\n\n\n\n
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                <\/div><\/div>\n\n\n\n

                \u5c71\u5d0e \u670b\u4eba<\/h4>\n\n\n\n

                \u7814\u7a76\u4ee3\u8868\u8005
                \u9ad8\u77e5\u5927\u5b66\u7406\u5de5\u5b66\u90e8\u3000\u51c6\u6559\u6388
                \u7814\u7a76\u5ba4HP<\/mark>\u3000http:\/\/science.cc.kochi-u.ac.jp\/?course=4091<\/a>
                Researchmap<\/mark>\u3000                https:\/\/researchmap.jp\/ytomohito<\/a>
                ORCID<\/mark>\u3000                https:\/\/orcid.org\/0000-0001-9157-0209<\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n

                \n
                \n

                \u8a73\u7d30\u3092\u898b\u308b<\/p>\n<\/span><\/div>\n\n\n\n

                \n

                \u690d\u7269\u306b\u5e83\u304f\u898b\u3089\u308c\u308b\u8449\u7dd1\u4f53\u30b2\u30ce\u30e0DNA\uff08Chloroplast DNA\u3001\u4ee5\u5f8ccpDNA\uff09\u306e\u7247\u89aa\u907a\u4f1d\u306f\u3001\u8449\u7dd1\u4f53\u304c\u81ea\u8eab\u306e\u30b2\u30ce\u30e0\u3092\u5b50\u5b6b\u306b\u4f1d\u3048\u308b\u91cd\u8981\u306a\u30d7\u30ed\u30bb\u30b9\u3067\u3042\u308b\u3002\u7dd1\u85fb\u30af\u30e9\u30df\u30c9\u30e2\u30ca\u30b9\u3067\u3082cpDNA\u304c\u6bcd\u6027\u907a\u4f1d\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3001\u7247\u89aa\u907a\u4f1d\u306e\u30e2\u30c7\u30eb\u3068\u3057\u3066\u53e4\u304f\u304b\u3089\u7814\u7a76\u3055\u308c\u3066\u3044\u308b\u3002\u3057\u304b\u3057\u3001\u305d\u306e\u5206\u5b50\u6a5f\u69cb\u306e\u5168\u5bb9\u306f\u672a\u3060\u660e\u3089\u304b\u3067\u306f\u306a\u3044\u3002\u79c1\u305f\u3061\u306f\u3001\u30af\u30e9\u30df\u30c9\u30e2\u30ca\u30b9\u306b\u304a\u3051\u308bcpDNA\u6bcd\u6027\u907a\u4f1d\u306e\u53b3\u5bc6\u6027\u304cmicroRNA \uff08miRNA\uff09\u306e\u6a5f\u80fd\u3057\u306a\u3044\u5909\u7570\u4f53\u306b\u304a\u3044\u3066\u640d\u306a\u308f\u308c\u3001\u7236\u6027cpDNA\u3082\u907a\u4f1d\u3059\u308b\u4e21\u6027\u907a\u4f1d\u304c\u7d0430%\u306e\u5b50\u5b6b\u3067\u8d77\u3053\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u305f\u3002\u3053\u308c\u306f\u3001miRNA\u304ccpDNA\u6bcd\u6027\u907a\u4f1d\u306e\u53b3\u5bc6\u6027\u3092\u7dad\u6301\u3059\u308b\u5f79\u5272\u3092\u6301\u3064\u3053\u3068\u3092\u793a\u5506\u3059\u308b\u304c\u3001\u30af\u30e9\u30df\u30c9\u30e2\u30ca\u30b9\u306b\u9650\u3089\u305a\u540c\u69d8\u306e\u5831\u544a\u306f\u306a\u304f\u3001\u305d\u306e\u5206\u5b50\u6a5f\u69cb\u3082\u4e0d\u660e\u3067\u3042\u308b\u3002\u672c\u7814\u7a76\u3067\u306f\u3001\u4e3b\u3068\u3057\u3066HITS-CLIP\u89e3\u6790\u304b\u3089miRNA\u304c\u6bcd\u6027\u907a\u4f1d\u3092\u6210\u7acb\u3055\u305b\u308b\u5206\u5b50\u6a5f\u69cb\u306e\u89e3\u660e\u306b\u7740\u624b\u3059\u308b\u3002\u672c\u7814\u7a76\u306b\u3088\u3063\u3066miRNA\u306b\u3088\u308b\u5236\u5fa1\u3068\u3044\u3046\u65b0\u3057\u3044\u8996\u70b9\u304b\u3089\u6bcd\u6027\u907a\u4f1d\u306e\u7406\u89e3\u304c\u6df1\u307e\u308a\u3001\u672c\u9818\u57df\u306e\u9032\u5c55\u306b\u7e4b\u304c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u308b\u3002<\/p>\n\n\n\n

                \"\"<\/figure>\n\n\n\n

                \u7814\u7a76\u696d\u7e3e\u3000*\u8cac\u4efb\u8457\u8005<\/span><\/h3>\n\n\n\n
                  \n
                1. Murakami S, Takahashi H, Shimizu H, Yamasaki T* (2025) Global Identification of AGO3\u2013RNA Interactions Reveals Targets of Small RNA\u2013mediated Gene Regulation in Chlamydomonas reinhardtii<\/em>. Plant Cell Physiol.<\/em><\/strong> accepted<\/li>\n\n\n\n
                2. Yamasaki T*, Tokutsu R, Sawa H, Razali NN, Hayashi M, Minagawa J (2023) Small RNA-mediated silencing of phototropin suppresses the induction of photoprotection in the green alga Chlamydomonas reinhardtii<\/em>. Proc Natl Acad Sci U S A. <\/em><\/strong>120, e2302185120.<\/li>\n\n\n\n
                3. Yamasaki T*, Onishi M, Kim EJ, Cerutti H, Ohama T (2016) RNA-binding protein DUS16 plays an essential role in primary miRNA processing in the unicellular alga Chlamydomonas reinhardtii.<\/em> Proc Natl Acad Sci U S A.<\/em><\/strong> 113, pp.10720-10725.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n\n\n\n
                  <\/div>\n\n\n\n

                  B01-6\uff1a\u611f\u67d3\u5fae\u751f\u7269\u306b\u3088\u308b\u5bbf\u4e3b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u30de\u30cb\u30d4\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3<\/strong><\/strong><\/strong><\/strong><\/h3>\n\n\n\n
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                  \"\"<\/figure>\n<\/div>\n\n\n\n
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                  \u5c0f\u67f4 \u7422\u5df1<\/h4>\n\n\n\n

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                  \u798f\u5ca1\u5927\u5b66\u30fb\u7406\u5b66\u90e8\u3000\u6559\u6388
                  \u7814\u7a76\u5ba4HP<\/mark>\u3000https:\/\/www.sci.fukuoka-u.ac.jp\/lab\/chem\/koshiba\/<\/a>
                  Researchmap<\/mark>\u3000                  https:\/\/researchmap.jp\/read0124036\/?lang=japanese<\/a>
                  ORCID<\/mark>\u3000                  https:\/\/orcid.org\/0000-0001-8535-5043<\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n

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                  \u8a73\u7d30\u3092\u898b\u308b<\/p>\n<\/span><\/div>\n\n\n\n

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                  \u3000\u597d\u6c17\u6027\u7d30\u83cc\u3092\u8d77\u6e90\u3068\u3059\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306f\u3001\u771f\u6838\u751f\u7269\u3078\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u63d0\u4f9b\u4ee5\u5916\u306b\u3082\u611f\u67d3\u5fae\u751f\u7269\u306b\u5bfe\u3059\u308b\u751f\u4f53\u9632\u5fa1\uff08\u81ea\u7136\u514d\u75ab\uff09\u306e\u6700\u524d\u7dda\u3067\u6a5f\u80fd\u3059\u308b\u3002\u3053\u306e\u514d\u75ab\u7cfb\u3067\u306f\u3001\u4fb5\u5165\u8005\u3092\u5bbf\u4e3b\u5916\u3078\u6392\u9664\u3059\u308b\u305f\u3081\u306b\u69d8\u3005\u306a\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u53cd\u5fdc\u304c\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5916\u819c\u4e0a\u3067\u884c\u308f\u308c\u308b\u3002\u672c\u7814\u7a76\u3067\u306f\u3001\u300e\u7d30\u80de\u5185\u306b\u304a\u3051\u308b\u5bbf\u4e3b\uff0d\u5fae\u751f\u7269\u9593\u306e\u751f\u547d\u62ee\u6297\u30d7\u30ed\u30bb\u30b9\u300f\u306b\u3064\u3044\u3066\u53d6\u308a\u4e0a\u3052\u308b\u3002\u7279\u306b\u3001\u5fae\u751f\u7269\u306e\u5bbf\u4e3b\u4fb5\u5165\u306b\u4f34\u3044\u3001\u65b0\u305f\u306b\u79fb\u5165\u3055\u308c\u305f\u7b2c\u4e8c\u306e\u7d30\u80de\u8cea\u30b2\u30ce\u30e0\u304c\u5bbf\u4e3b\u5185\u3067\u3069\u306e\u3088\u3046\u306b\u7dad\u6301\u30fb\u8907\u88fd\uff08\u5bbf\u4e3b\u514d\u75ab\u7cfb\u304b\u3089\u306e\u5fcc\u907f\uff09\u3055\u308c\u3001\u307e\u305f\u6a5f\u80fd\u767a\u73fe\uff08\u7a81\u7834\uff09\u3078\u3068\u7e4b\u304c\u308b\u306e\u304b\u3001\u305d\u306e\u4ed5\u7d44\u307f\u306b\u95a2\u308f\u308b\u5206\u5b50\u6a5f\u5e8f\u3092\u4fb5\u7565\u5074\u306e\u8996\u70b9\u3092\u901a\u3057\u3066\u611f\u67d3\u73fe\u8c61\u306e\u672c\u8cea\u7684\u306a\u7406\u89e3\u3092\u76ee\u6307\u3059\u3002\u6211\u3005\u306f\u3053\u308c\u307e\u3067\u3001\u5f53\u8a72\u5206\u91ce\u3067\u672a\u89e3\u660e\u3060\u3063\u305f\u514d\u75ab\u7cfb\u306b\u304a\u3051\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u65b0\u305f\u306a\u5f79\u5272\u3092\u4e16\u754c\u306b\u5148\u99c6\u3051\u3066\u660e\u3089\u304b\u306b\u3057\u3066\u304d\u305f\u3002\u672c\u7814\u7a76\u3067\u306f\u3001\u7d30\u80de\u5185\u3067\u5171\u751f\u95a2\u4fc2\u3092\u80b2\u3080\u5bbf\u4e3b\uff0d\u5fae\u751f\u7269\u306e\u5168\u8c8c\u306b\u3001\u5916\u6765\u30b2\u30ce\u30e0\u3088\u308a\u7ffb\u8a33\u3055\u308c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u7fa4\u304b\u3089\u5bbf\u4e3b\u5074\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3078\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u8ef8\u306b\u3001\u672c\u9818\u57df\u304c\u76ee\u6307\u3059\u300c\u7d30\u80de\u8cea\u30b2\u30ce\u30e0\u304c\u62c5\u3046\u751f\u547d\u73fe\u8c61\u306e\u89e3\u660e\u300d\u306b\u8feb\u308a\u305f\u3044\u3002<\/p>\n\n\n\n

                  \"\"<\/figure>\n\n\n\n

                  \u7814\u7a76\u696d\u7e3e\u3000*\u8cac\u4efb\u8457\u8005<\/span><\/h3>\n\n\n\n
                    \n
                  1. Ban, T., Kuroda, K., Nishigori, M., Yamashita, K., Ohta, K., and *Koshiba, T. (2025) Prohibitin 1 tethers lipid membranes and regulates OPA1-mediated membrane fusion. J. Biol. Chem.<\/em><\/strong>, 301, 108076.<\/li>\n\n\n\n
                  2. Nakai, A., Fukushima, Y., Yamamoto, A., Amatsu, Y., Chen, X., Nishigori, M., Yoshioka, Y., Kaneko, M., *Koshiba, T., and *Watanabe, T. (2024) Increased ROS levels in mitochondrial outer membrane protein Mul1-deficient oocytes result in abnormal preimplantation embryogenesis. FEBS Lett.<\/em><\/strong>, 598, 1740-1752.<\/li>\n\n\n\n
                  3. Yasukawa, K., Kinoshita, D., Yaku, K., Nakagawa, T., and *Koshiba, T. (2020) The microRNAs miR-302b and miR-372 regulate mitochondrial metabolism via the SLC25A12 transporter, which controls MAVS-mediated antiviral innate immunity. J. Biol. Chem.<\/em><\/strong>, 295, 444-457.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n\n\n\n
                    <\/div>\n\n\n\n

                    B01-7\uff1a\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA\u306e\u30df\u30bb\u30eb\u69d8\u6838\u69d8\u4f53\u5f62\u6210\u306b\u3088\u308b\u8ee2\u5199\u5236\u5fa1\u6a5f\u69cb\u306e\u7269\u7406<\/strong><\/strong><\/strong><\/strong><\/h3>\n\n\n\n
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                    \u5c71\u672c \u54f2\u4e5f<\/h4>\n\n\n\n

                    \u7814\u7a76\u4ee3\u8868\u8005
                    \u5317\u6d77\u9053\u5927\u5b66\u30fb\u5316\u5b66\u53cd\u5fdc\u5275\u6210\u7814\u7a76\u62e0\u70b9\u3000\u7279\u4efb\u51c6\u6559\u6388
                    \u7814\u7a76\u5ba4HP<\/mark>\u3000https:\/\/www.icredd.hokudai.ac.jp\/ja\/yamamoto-tetsuya<\/a>
                    Researchmap<\/mark>\u3000                    https:\/\/researchmap.jp\/tetsuwis<\/a>
                    ORCID<\/mark>\u3000                    https:\/\/orcid.org\/0000-0002-6786-8299<\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n

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                    \u8a73\u7d30\u3092\u898b\u308b<\/p>\n<\/span><\/div>\n\n\n\n

                    \n

                    \u3000\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA\uff08mtDNA\uff09\u306e\u8ee2\u5199\u91cf\u306f\u3001\u8ee2\u5199\u56e0\u5b50\u3067\u3042\u308bTFAM\u306e\u6fc3\u5ea6\u306b\u5bfe\u3057\u3066\u975e\u5358\u8abf\u306a\u4f9d\u5b58\u6027\u3092\u793a\u3059\u3002TFAM\u304c\u914d\u5217\u975e\u4f9d\u5b58\u7684\u306bmtDNA\u3068\u7d50\u5408\u3057\u3066\u6838\u69d8\u4f53\u3092\u5f62\u6210\u3059\u308b\u304c\u3053\u306e\u975e\u5358\u8abf\u6027\u306e\u539f\u56e0\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002\u6838\u69d8\u4f53\u306fTFAM\u306e\u6db2\u6db2\u76f8\u5206\u96e2\u306b\u3088\u3063\u3066\u5f62\u6210\u3055\u308c\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u304d\u305f\u304c\u3001\u6700\u8fd1\u306e\u5b9f\u9a13\u304c\u660e\u3089\u304b\u306b\u3057\u305f\u6838\u69d8\u4f53\u306e\u7279\u5fb4\u306f\u3001\u30df\u30bb\u30eb\u3068\u985e\u4f3c\u3057\u3066\u3044\u308b\u3002\u7533\u8acb\u8005\u306f\u3001\u51dd\u96c6\u6027\u3092\u6301\u3064\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u6838\u9178\u306e\u8907\u5408\u4f53\u306b\u3088\u308b\u30df\u30bb\u30eb\u69d8\u69cb\u9020\u4f53\u306e\u5f62\u6210\u6a5f\u69cb\u3068DNA\u306e\u53ce\u7e2e\u306b\u3088\u308b\u8ee2\u5199\u5236\u5fa1\u6a5f\u69cb\u306b\u95a2\u3059\u308b\u7406\u8ad6\u3092\u69cb\u7bc9\u3057\u3066\u304d\u305f\u3002\u672c\u7814\u7a76\u306e\u76ee\u7684\u306f\u3001\u7533\u8acb\u8005\u304c\u69cb\u7bc9\u3057\u3066\u304d\u305f\u3053\u308c\u3089\u306e\u7406\u8ad6\u30e2\u30c7\u30eb\u3092\u6838\u69d8\u4f53\u306b\u62e1\u5f35\u3057\u3001mtDNA\u306e\u8ee2\u5199\u5236\u5fa1\u6a5f\u69cb\u3092\u7406\u8ad6\u7684\u306b\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u3067\u3042\u308b\u3002\u672c\u7814\u7a76\u3067\u306f\u3001\u2460\u6838\u69d8\u4f53\u3092\u30df\u30bb\u30eb\u69d8\u69cb\u9020\u4f53\u3068\u3057\u3066\u8003\u3048\u308b\u70b9\u3068\u2461\u30df\u30bb\u30eb\u69d8\u69cb\u9020\u4f53\u306e\u7279\u5fb4\u304c\u8ee2\u5199\u5236\u5fa1\u306b\u4e0e\u3048\u308b\u5bc4\u4e0e\u3092\u89e3\u6790\u3059\u308b\u70b9\u3067\u72ec\u5275\u7684\u3067\u3042\u308a\u3001\u9818\u57df\u76ee\u6a19\u3067\u3042\u308b\u7d30\u80de\u8cea\u30b2\u30ce\u30e0\u306e\u751f\u7406\u6a5f\u80fd\u306e\u89e3\u660e\u306b\u5fc5\u8981\u306amtDNA\u306e\u907a\u4f1d\u5b50\u5236\u5fa1\u6a5f\u69cb\u3092\u30bd\u30d5\u30c8\u30de\u30bf\u30fc\u7406\u8ad6\u7269\u7406\u5b66\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u3067\u7a76\u660e\u3059\u308b\u3002<\/p>\n\n\n\n

                    \"\"<\/figure>\n\n\n\n

                    \u7814\u7a76\u696d\u7e3e\u3000*\u8cac\u4efb\u8457\u8005<\/span><\/h3>\n\n\n\n
                      \n
                    1. Yamamoto T*, Yamazaki T, and Hirose T (2022) Triblock copolymer model of spherical paraspeckles. Front. Mol. Biosci.,<\/em><\/strong> 9: 925058.<\/li>\n\n\n\n
                    2. Yamamoto T*, Yamazaki T*, Ninomiya K, and Hirose T (2023) Nascent ribosomal RNA act as surfactant that suppresses growth of fibrillar ceters in nucleolus. Comms. Biol.,<\/em><\/strong> 6: 1129.<\/li>\n\n\n\n
                    3. Yamamoto T*, Asanuma T*, and Murakami Y (2023) Polymeric nature of tandemly repeated genes enhances assembly of constitutive chromatin in fission yeast. Comms. Biol.,<\/em><\/strong> 6: 796.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n\n\n\n
                      <\/div>\n\n\n\n

                      B01-8\uff1a\u6539\u826f\u578bChIP\u6cd5\u306b\u3088\u308a\u8449\u7dd1\u4f53\u5185\u90e8\u3067\u306e\u3042\u3089\u3086\u308b\u8ee2\u5199\u5236\u5fa1\u3092\u89e3\u304d\u660e\u304b\u3059<\/strong><\/strong><\/strong><\/strong><\/strong><\/h3>\n\n\n\n
                      \n
                      \n
                      \"\"<\/figure>\n<\/div>\n\n\n\n
                      \n
                      <\/div><\/div>\n\n\n\n

                      \u85e4\u4e95 \u7965<\/h4>\n\n\n\n

                      \u7814\u7a76\u4ee3\u8868\u8005
                      \u5f18\u524d\u5927\u5b66\u30fb\u8fb2\u5b66\u751f\u547d\u79d1\u5b66\u90e8\u3000\u52a9\u6559
                      \u7814\u7a76\u5ba4HP<\/mark>\u3000https:\/\/sites.google.com\/view\/shofujii-hirosaki-u\/<\/a>
                      Researchmap<\/mark>\u3000                      https:\/\/researchmap.jp\/shofujii<\/a>
                      ORCID<\/mark>\u3000                      https:\/\/orcid.org\/0000-0002-6260-5596<\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n

                      \n
                      \n

                      \u8a73\u7d30\u3092\u898b\u308b<\/p>\n<\/span><\/div>\n\n\n\n

                      \n

                      \u3000\u672c\u7814\u7a76\u3067\u306f\uff0c\u8449\u7dd1\u4f53\u306e2\u7a2e\u985e\u306eRNA\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc\u306e\u6a5f\u80fd\u5236\u5fa1\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\u3092\u2f6c\u6307\u3059\u3002\u8449\u7dd1\u4f53\u306f\uff0c\u7d30\u83cc\u578b\u3068\u30d5\u30a1\u30fc\u30b8\u578b\u3068\u3044\u3046\u8d77\u6e90\u306e\u7570\u306a\u308b2\u7a2e\u985e\u306e\u8ee2\u5199\u88c5\u7f6e\u3092\u3082\u3064\u3002\u3053\u306e\u2f06\u91cd\u306e\u8ee2\u5199\u30b7\u30b9\u30c6\u30e0\u306f\uff0c\u9678\u4e0a\u690d\u7269\u304c\u9032\u5316\u306e\u904e\u7a0b\u3067\u7372\u5f97\u3057\u305f\u8449\u7dd1\u4f53\u306e\u6a5f\u80fd\u5236\u5fa1\u300c\u8272\u7d20\u4f53\u5206\u5316\u300d\u306b\u91cd\u8981\u306a\u4ed5\u7d44\u307f\u3067\u3042\u308b\u3002\u8449\u7dd1\u4f53RNA\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc\u306e\u907a\u4f1d\u2f26\u306f\u3059\u3079\u3066\u540c\u5b9a\u3055\u308c\u3066\u3044\u308b\u304c\uff0c\u8449\u7dd1\u4f53\u306e\u6a5f\u80fd\u5206\u5316\u6642\u306b\u8ee2\u5199\u6d3b\u6027\u304c\u8abf\u7bc0\u3055\u308c\u308b\u6a5f\u69cb\u306b\u3064\u3044\u3066\u306f\u672a\u89e3\u660e\u306e\u70b9\u304c\u591a\u304f\u6b8b\u3055\u308c\u3066\u3044\u308b\u3002\u5f93\u6765\uff0c\u8449\u7dd1\u4f53\u306e\u8ee2\u5199\u6d3b\u6027\u306e\u8a55\u4fa1\u306b\u306f\uff0c\u2f24\u91cf\u306e\u690d\u7269\u6750\u6599\u304b\u3089\u53d6\u308a\u51fa\u3057\u305fRNA\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc\u306e\u2f63\u5316\u5b66\u7684\u306a\u5206\u6790\u304c\u5fc5\u8981\u3067\u3042\u308a\uff0c\u3053\u3053\u306b\u6280\u8853\u7684\u306a\u9650\u754c\u304c\u3042\u3063\u305f\u3002\u7533\u8acb\u8005\u306f\u3053\u306e\u6570\u5e74\u9593\uff0c\u2f63\u4f53\u5185\u306e\u8449\u7dd1\u4f53RNA\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc\u306e\u72b6\u614b\u3092\u76f4\u63a5\uff0c\u9ad8\u611f\u5ea6\u306b\u691c\u51fa\u3067\u304d\u308bptChIP\u6cd5\u3092\u958b\u767a\u3057\u3066\u304d\u305f\u3002\u307e\u305f\uff0c\u8449\u7dd1\u4f53\u306e\u819c\u306e\u72b6\u614b\u304c\u8449\u7dd1\u4f53\u5206\u5316\u6642\u306eRNA\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc\u306e\u6a5f\u80fd\u5236\u5fa1\u306b\u2f24\u304d\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u3092\u7a81\u304d\u6b62\u3081\u3066\u3044\u308b\u3002\u8449\u7dd1\u4f53\u306e\u8ee2\u5199\u306b\u5bfe\u3059\u308b\u7406\u89e3\u304c\u9032\u5c55\u3057\uff0cRNA\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc\u306e\u6a5f\u80fd\u3078\u306e\u4ecb\u2f0a\u3068\u76f4\u63a5\u7684\u306a\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u304c\u53ef\u80fd\u306b\u306a\u3063\u305f\u4eca\uff0c\u8b0e\u306e\u591a\u3044\u8449\u7dd1\u4f53\u306e\u8ee2\u5199\u5236\u5fa1\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\u306b\u6311\u6226\u3059\u308b\u3002<\/p>\n\n\n\n

                      \"\"<\/figure>\n\n\n\n

                      \u7814\u7a76\u696d\u7e3e\u3000*\u8cac\u4efb\u8457\u8005<\/span><\/h3>\n\n\n\n
                        \n
                      1. Palomar VM, Cho Y, Fujii S, Rothi MH, Jaksich S, Min J-H, Schlachter AN, Wang J, Liu Z, Wierzbicki AT* (2024) Membrane association of active genes organizes the chloroplast nucleoid structure. Proc Natl Acad Sci USA<\/em><\/strong>, 121: e2309244121.<\/li>\n\n\n\n
                      2. Fujii S*, Wada H, Kobayashi K (2024) Orchestration of Photosynthesis-Associated Gene Expression and Galactolipid Biosynthesis during Chloroplast Differentiation in Plants. Plant Cell Physiol<\/em><\/strong>, 65: 1014\u20131028.<\/li>\n\n\n\n
                      3. Fujii S, Kobayashi K*, Lin YC, Liu Y, Nakamura Y, Wada H (2022) Impacts of phosphatidylglycerol on plastid gene expression and light induction of nuclear photosynthetic genes. J Exp Bot<\/em><\/strong>, 73: 2952\u20132970.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n\n\n\n
                        <\/div>\n\n\n\n

                        B02\u3000\u5229\u7528\u5c55\u958b<\/p>\n\n\n\n

                        \u8a08\u753b\u73ed<\/h2>\n\n\n\n

                        B02-1\uff1a\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u4ecb\u5165\u306b\u3088\u308b\u751f\u4f53\u6a5f\u80fd\u4ea2\u9032\u6280\u8853\u306e\u69cb\u7bc9<\/strong><\/strong><\/strong><\/strong><\/strong><\/h3>\n\n\n\n
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                        \"\"<\/figure>\n<\/div>\n\n\n\n
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                        <\/div><\/div>\n\n\n\n

                        \u77f3\u539f \u76f4\u5fe0<\/h4>\n\n\n\n

                        \u7814\u7a76\u4ee3\u8868\u8005
                        \u5927\u962a\u5927\u5b66\u5927\u5b66\u9662\u7406\u5b66\u7814\u7a76\u79d1\u3000\u6559\u6388
                        \u7814\u7a76\u5ba4HP<\/mark>\u3000https:\/\/mitochondria.jp\/<\/a>
                        Researchmap<\/mark>\u3000                        https:\/\/researchmap.jp\/10325516\/?lang=japanese<\/a>
                        ORCID<\/mark>\u3000                        https:\/\/orcid.org\/0000-0002-6305-7149<\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n

                        \n

                        \u7814\u7a76\u5206\u62c5\u8005<\/h3>\n\n\n\n

                        \u5c0f\u7b20\u539f\u7d75\u7f8e (\u5927\u962a\u5927\u30fb\u7406\u5b66\u30fb\u52a9\u6559\u30fb\u5206\u5b50\u7d30\u80de\u751f\u7269\u5b66\u30fb\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u75c5\u614b\u89e3\u6790)<\/p>\n\n\n\n

                        \n
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                        \"\"
                        \u5c0f\u7b20\u539f \u7d75\u7f8e<\/figcaption><\/figure>\n<\/div>\n\n\n\n
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                        \u8a73\u7d30\u3092\u898b\u308b<\/p>\n<\/span><\/div>\n\n\n\n

                        \n

                        \u54fa\u4e73\u985e\u57f9\u990a\u7d30\u80de\u306e\u7d30\u9577\u304f\u679d\u5206\u304b\u308c\u3057\u305f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306f\u751f\u7d30\u80de\u5185\u3067\u6d3b\u767a\u306b\u52d5\u304d\u3001\u305d\u306e\u5f62\u614b\u306f\u878d\u5408\u3068\u5206\u88c2\u306e\u30d0\u30e9\u30f3\u30b9\u306b\u3088\u308a\u5236\u5fa1\u3055\u308c\u3066\u3044\u308b\u3002\u3057\u304b\u3057\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5185\u90e8\u306eDNA (mtDNA) \u306f\u3069\u306e\u3088\u3046\u306b\u5206\u914d\u3055\u308c\u6a5f\u80fd\u767a\u73fe\u3059\u308b\u304b\u3001\u305d\u306e\u819c\u3068\u30b2\u30ce\u30e0\u306e\u5354\u8abf\u7684\u306a\u5236\u5fa1\u306e\u8a73\u7d30\u306f\u4e0d\u660e\u3067\u3042\u308b\u3002\u305d\u3053\u3067\u672c\u7814\u7a76\u3067\u306f\u591a\u91cd\u819c\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u30c0\u30a4\u30ca\u30df\u30af\u30b9\u306e\u8996\u70b9\u306b\u7acb\u811a\u3057\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u30b2\u30ce\u30e0\u306e\u6a5f\u80fd\u767a\u73fe\u5236\u5fa1 (\u547c\u5438\u9396\u8907\u5408\u4f53\u5f62\u6210\u3084mtDNA\u306e\u5b89\u5b9a\u5316\u30fb\u7d30\u80de\u8cea\u907a\u4f1d\u7b49) \u306e\u5206\u5b50\u57fa\u76e4\u7406\u89e3\u3092\u76ee\u6307\u3059\u3002\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u3001\u6838\u69d8\u4f53\u306e\u5206\u6563\u5316\u306b\u3088\u308a\u547c\u5438\u9396\u5f62\u6210\u304c\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3001\u307e\u305f\u305d\u306e\u5236\u5fa1\u306b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5206\u88c2\u56e0\u5b50\u3084mtDNA\u7d50\u5408\u30fb\u30d1\u30c3\u30b1\u30fc\u30b8\u30f3\u30b0\u56e0\u5b50\u7fa4\u304c\u95a2\u4e0e\u3059\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u3066\u3044\u308b\u3002\u95a2\u9023\u56e0\u5b50\u306e\u540c\u5b9a\u53ca\u3073\u5206\u5b50\u6a5f\u69cb\u306e\u8a73\u7d30\u7406\u89e3\u304b\u3089\u5206\u5b50\u8a73\u7d30\u7406\u89e3\u3092\u76ee\u6307\u3059\u3002\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u4f4e\u4e0b\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u75c5\u306e\u307f\u306a\u3089\u305a\u3001\u8001\u5316\u3084\u7cd6\u5c3f\u75c5\u30fb\u4ee3\u8b1d\u75be\u60a3\u30fb\u795e\u7d4c\u5909\u6027\u75be\u60a3\u7b49\u306e\u4e00\u56e0\u3068\u306a\u308b\u3002\u672c\u7814\u7a76\u6210\u679c\u3092\u3082\u3068\u306b\u3057\u3066\u3001\u7d30\u80de\u30fb\u500b\u4f53\u5185\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6d3b\u6027\u5316\u6280\u8853\u3092\u69cb\u7bc9\u3059\u308b\u3002 \u672c\u9818\u57df\u3067\u5f97\u3089\u308c\u305f\u5206\u5b50\u77e5\u898b\u3092\u57fa\u306b\u3001\u95a2\u9023\u75be\u60a3\u306e\u81e8\u5e8a\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u3068\u306e\u9023\u643a\u3092\u6a21\u7d22\u3059\u308b\u3002\u307e\u305f\u3001\u672c\u7814\u7a76\u306b\u3088\u308a\u5f97\u3089\u308c\u308b\u5206\u5b50\u7406\u89e3\u306f\u3001\u7a2e\u3092\u8d85\u3048\u305f\u7d30\u80de\u8cea\u30b2\u30ce\u30e0\u5236\u5fa1\u6280\u8853\u306e\u9769\u65b0\u306b\u5411\u3051\u305f\u57fa\u76e4\u77e5\u8b58\u3092\u4e0e\u3048\u308b\u3002\u307e\u305f\u3001\u9818\u57df\u5185\u306e\u54fa\u4e73\u985e\u306e\u547c\u5438\u8a08\u6e2c\u7b49\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u89e3\u6790\u3092\u5e83\u304f\u652f\u63f4\u3059\u308b\u3053\u3068\u3067\u3082\u672c\u9818\u57df\u306e\u767a\u5c55\u306b\u8ca2\u732e\u3059\u308b\u3002<\/p>\n\n\n\n

                        \"\"<\/figure>\n\n\n\n

                        \u7814\u7a76\u696d\u7e3e\u3000*\u8cac\u4efb\u8457\u8005<\/span><\/h3>\n\n\n\n
                          \n
                        1. Ishihara T, Ban-Ishihara R, Ota A, Ishihara N* (2022) Mitochondrial nucleoid trafficking regulated by the inner-membrane AAA-ATPase ATAD3A modulates respiratory complex formation. Proc Natl Acad Sci USA<\/em><\/strong>, 119: e2210730119.<\/li>\n\n\n\n
                        2. Hanada Y, Ishihara N*, Wang L, Otera H, Ishihara T, Koshiba T, Mihara K, Ogawa Y, Nomura M (2020) MAVS is energized by Mff which senses mitochondrial metabolism via AMPK for acute antiviral immunity. Nat Commun<\/em><\/strong>, 11: 5711.<\/li>\n\n\n\n
                        3. Ban T, Ishihara T, Kohno H, Saita S, Ichimura A, Maenaka K, Oka T, Mihara K, Ishihara N* (2017) Molecular basis of selective mitochondrial fusion by heterotypic action between OPA1 and cardiolipin. Nat Cell Biol<\/em><\/strong>, 19: 856\u2013863.<\/li>\n\n\n\n
                        4. Ban-Ishihara R, Ishihara T, Sasaki N, Mihara K, Ishihara N* (2013) Dynamics of nucleoid structure regulated by mitochondrial fission contributes to cristae reformation and release of cytochrome c<\/em>. Proc Natl Acad Sci USA<\/em><\/strong>, 110: 11863\u201311868.<\/li>\n\n\n\n
                        5. Ishihara N, Nomura M, Jofuku A, Kato H, Suzuki SO, Masuda K, Otera H, Nakanishi Y, Nonaka I, Goto Y, Taguchi N, Morinaga H, Maeda M, Takayanagi R, Yokota S, Mihara K* (2009) Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice. Nat Cell Biol<\/em><\/strong>, 11: 958\u2013966.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n\n\n\n
                          <\/div>\n\n\n\n

                          B02-2\uff1a\u7d30\u80de\u8cea\u30b2\u30ce\u30e0\u7de8\u96c6\u6280\u8853\u306b\u3088\u308b\u9ad8\u3044\u5149\u5408\u6210\u80fd\u3092\u6709\u3059\u308b\u690d\u7269\u306e\u5275\u51fa\u3068\u305d\u306e\u6a5f\u80fd\u89e3\u660e<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/h3>\n\n\n\n
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                          \"\"<\/figure>\n<\/div>\n\n\n\n
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                          \u77e2\u5b88 \u822a<\/h4>\n\n\n\n

                          \u7814\u7a76\u4ee3\u8868\u8005
                          \u6771\u4eac\u5927\u5b66\u5927\u5b66\u9662\u8fb2\u5b66\u751f\u547d\u79d1\u5b66\u7814\u7a76\u79d1\u3000\u51c6\u6559\u6388
                          \u7814\u7a76\u5ba4HP<\/mark>\u3000https:\/\/park.itc.u-tokyo.ac.jp\/yamori-lab\/index.html<\/a>
                          Researchmap<\/mark>\u3000                          https:\/\/researchmap.jp\/wataru.yamori\/?lang=japanese<\/a>
                          ORCID<\/mark>\u3000                          https:\/\/orcid.org\/0000-0001-7215-4736<\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n

                          \n

                          \u7814\u7a76\u5206\u62c5\u8005<\/h3>\n\n\n\n

                          \u6df1\u5c71\u6d69 (\u795e\u6238\u5927\u30fb\u8fb2\u5b66\u30fb\u6559\u6388\u30fb\u690d\u7269\u5206\u5b50\u751f\u7269\u5b66\u30fbRubisco\u6a5f\u80fd\u89e3\u6790)\u3001
                          \u677e\u6751\u6d69\u7531(\u7acb\u547d\u9928\u5927\u30fb\u751f\u547d\u79d1\u5b66\u30fb\u6559\u6388\u30fb\u69cb\u9020\u751f\u7269\u5316\u5b66\u30fb\u7d50\u6676\u69cb\u9020\u89e3\u6790)<\/p>\n\n\n\n

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                          \u6df1\u5c71 \u6d69<\/figcaption><\/figure>\n<\/div>\n\n\n\n
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                          \u677e\u6751 \u6d69\u7531<\/figcaption><\/figure>\n<\/div>\n\n\n\n
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                          \u8a73\u7d30\u3092\u898b\u308b<\/p>\n<\/span><\/div>\n\n\n\n

                          \n

                          \u56fd\u5185\u5916\u306b\u304a\u3044\u3066\u3001\u4f5c\u7269\u306e\u5149\u5408\u6210\u6539\u826f\u306b\u5411\u3051\u305f\u53d6\u308a\u7d44\u307f\u304c\u9032\u884c\u3057\u3066\u3044\u308b\u304c\u3001\u3053\u308c\u3089\u306e\u7814\u7a76\u306f\u5168\u3066\u6838\u30b2\u30ce\u30e0\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3057\u305f\u5358\u72ec\u3042\u308b\u3044\u306f\u8907\u6570\u306e\u5916\u6765\u907a\u4f1d\u5b50\u5c0e\u5165\u306b\u3088\u308b\u690d\u7269\u6539\u5909\u304c\u4e3b\u3067\u3042\u308a\u3001\u629c\u672c\u7684\u306a\u5149\u5408\u6210\u6539\u5584\u306b\u306f\u81f3\u3063\u3066\u3044\u306a\u3044\u3002\u5149\u5408\u6210\u901f\u5ea6\u306e\u4e3b\u8981\u306a\u5f8b\u901f\u56e0\u5b50\u306f\u3001\u89e6\u5a92\u901f\u5ea6\u304c\u975e\u5e38\u306b\u9045\u3044\u30ea\u30d6\u30ed\u30fc\u30b9-1\u30015-\u30d3\u30b9\u30ea\u30f3\u9178\u30ab\u30eb\u30dc\u30ad\u30b7\u30e9\u30fc\u30bc\/\u30aa\u30ad\u30b7\u30b2\u30ca\u30fc\u30bc(Rubisco) \u3067\u3042\u308b\u3053\u3068\u306f\u5468\u77e5\u306e\u4e8b\u5b9f\u3067\u3042\u308b\u304c\u3001\u305d\u306e\u89e6\u5a92\u90e8\u4f4drbcL\u304c\u8449\u7dd1\u4f53\u30b2\u30ce\u30e0\u306b\u30b3\u30fc\u30c9\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304b\u3089\u3001\u3053\u308c\u307e\u3067Rubisco\u306e\u89e6\u5a92\u7279\u6027\u306e\u6539\u826f\u306f\u56f0\u96e3\u3067\u3042\u3063\u305f\u3002\u305d\u3053\u3067\u3001\u672c\u8a08\u753b\u73ed\u3067\u306f\u6709\u6751\u73ed\u304c\u63d0\u4f9b\u3059\u308b\u201c\u8449\u7dd1\u4f53\u30b2\u30ce\u30e0\u7de8\u96c6\u6280\u8853\u201d\u3092\u6d3b\u7528\u3057\u3001Rubisco\u6539\u5909\u306b\u57fa\u3065\u304f\u5149\u5408\u6210\u80fd\u529b\u306e\u5f37\u5316\u3068\u305d\u308c\u3089\u306e\u6a5f\u80fd\u89e3\u660e\u3092\u76ee\u6307\u3059\u3002\u77e2\u5b88\u306f\u3001\u8449\u7dd1\u4f53\u30b2\u30ce\u30e0\u5168\u4f53\u3001\u3082\u3057\u304f\u306fRubisco\u89e6\u5a92\u90e8\u4f4drbcL\u907a\u4f1d\u5b50\u3092\u6a19\u7684\u3068\u3057\u305f\u30e9\u30f3\u30c0\u30e0\u5909\u7570\u96c6\u56e3\u306e\u4e2d\u304b\u3089\u3001\u9ad8\u3044\u5149\u5408\u6210\u80fd\u529b\u3092\u6709\u3059\u308b\u30b7\u30ed\u30a4\u30cc\u30ca\u30ba\u30ca\u5909\u7570\u4f53\u3092\u9078\u629c\u3057\u3001\u305d\u308c\u3089\u306e\u6a5f\u80fd\u89e3\u660e\u3092\u76ee\u6307\u3059\u3002\u307e\u305f\u3001Rubisco\u89e6\u5a92\u53cd\u5fdc\u306b\u5f71\u97ff\u3059\u308b\u3068\u4e88\u60f3\u3055\u308c\u308b\u90e8\u4f4d\u306e\u6a19\u7684\u4e00\u5869\u57fa\u7f6e\u63db\u6280\u8853\u306b\u3088\u3063\u3066\u3001Rubisco\u306e\u89e6\u5a92\u53cd\u5fdc\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\u3068\u9ad8\u3044\u89e6\u5a92\u53cd\u5fdc\u3092\u6709\u3059\u308bRubisco\u306e\u30c7\u30b6\u30a4\u30f3\u5316\u3092\u76ee\u6307\u3059\u3002\u6df1\u5c71\u306f\u3001\u30a4\u30cd\u3092\u7814\u7a76\u6750\u6599\u3068\u3057\u3066\u8449\u7dd1\u4f53\u30b2\u30ce\u30e0\u7de8\u96c6\u306b\u3088\u308arbcL\u3092\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u3057\u3001 \u8449\u7dd1\u4f53\u30c8\u30e9\u30f3\u30b8\u30c3\u30c8\u30da\u30d7\u30c1\u30c9\u3092\u4ed8\u52a0\u3057\u305f\u5916\u6765\u306erbcL\u3092\u5c0e\u5165\u3059\u308b\u5b9f\u9a13\u7cfb\u3092\u78ba\u7acb\u3059\u308b\u3002\u307e\u305f\u3001\u305d\u306e\u5b9f\u9a13\u7cfb\u3092\u7528\u3044\u3066\u89e6\u5a92\u901f\u5ea6\u306e\u9ad8\u3044C4\u690d\u7269\u306eRubisco\u306erbcL\u3084\u907a\u4f1d\u7684\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0GAOptimizer\u3092\u7528\u3044\u3066\u8a2d\u8a08\u3057\u305fC4\u6700\u9069\u5316\u30a4\u30cdrbcL\u3092\u5c0e\u5165\u3059\u308b\u3002\u3053\u308c\u3089\u5f62\u8cea\u8ee2\u63db\u4f53\u306e\u89e3\u6790\u304b\u3089\u3001Rubisco\u89e6\u5a92\u7279\u6027\u306e\u6539\u826f\u306b\u6709\u52b9\u306arbcL\u907a\u4f1d\u5b50\u306e\u5909\u7570\u3092\u63a2\u7d22\u3057\u3001Rubisco\u9175\u7d20\u7279\u6027\u306e\u6539\u826f\u3092\u76ee\u6307\u3059\u3002\u677e\u6751\u306f\u3001\u7d50\u6676\u69cb\u9020\u89e3\u6790\u3068\u30af\u30e9\u30a4\u30aa\u96fb\u5b50\u9855\u5fae\u93e1\u89e3\u6790\u3092\u5b9f\u65bd\u3057\u3001\u672c\u8a08\u753b\u73ed\u304c\u4f5c\u51fa\u3059\u308b\u9ad8\u52b9\u7387\u30fb\u9ad8\u6a5f\u80fd\u578bRubisco\u306e\u89e6\u5a92\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u5168\u5bb9\u89e3\u660e\u3092\u76ee\u6307\u3059\u3002\u77e2\u5b88\u306f\u30af\u30ed\u30ed\u30d5\u30a3\u30eb\u86cd\u5149\u3084\u30ac\u30b9\u4ea4\u63db\u6e2c\u5b9a\u7b49\u3092\u7528\u3044\u305f\u5149\u5408\u6210\/\u547c\u5438\u7cfb\u306e\u6a5f\u80fd\u89e3\u6790\u306b\u95a2\u3057\u3066\u3001\u307e\u305f\u3001 \u677e\u6751\u306f\u201c\u4eba\u5de5\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u201d\u3092\u7528\u3044\u305f\u30aa\u30eb\u30ac\u30cd\u30e9\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u69cb\u9020\u6a5f\u80fd\u89e3\u6790\u306b\u95a2\u3057\u3066\u3001\u9818\u57df\u5168\u4f53\u306e\u7814\u7a76\u652f\u63f4\u3092\u884c\u3046\u3002<\/p>\n\n\n\n

                          \"\"<\/figure>\n\n\n\n

                          \u7814\u7a76\u696d\u7e3e\u3000*\u8cac\u4efb\u8457\u8005<\/span><\/h3>\n\n\n\n
                            \n
                          1. Qu Y, Sakoda K, Fukayama H, Kondo E, Suzuki Y, Makino A, Terashima I, Yamori W* (2021) Overexpression of both Rubisco and Rubisco activase rescues rice photosynthesis and biomass under heat stress. Plant Cell Environ<\/em><\/strong>, 44: 2308\u20132320.<\/li>\n\n\n\n
                          2. Yamori W*, Kusumi K, Iba K, Terashima I (2020) Increased stomatal conductance induces rapid changes to photosynthetic rate in response to naturally fluctuating light conditions in rice. Plant Cell Environ<\/em><\/strong>, 43: 1230\u2013 1240.<\/li>\n\n\n\n
                          3. Ushijima T, Hanada K, Gotoh E, Yamori W, Kodama Y, Tanaka H, Kusano M, Fukushima A, Tokizawa M, Yamamoto Y, Tada Y, Suzuki Y, Matsushita T* (2017) Light controls protein localization through phytochrome-mediated alternative promoter selection. Cell<\/em><\/strong>, 171: 1316\u20131325.<\/li>\n\n\n\n
                          4. Yamori W*, Shikanai T (2016) Physiological functions of cyclic electron transport around photosystem I in sustaining photosynthesis and plant growth. Annu Rev Plant Biol<\/em><\/strong>, 67: 81\u2013106.<\/li>\n\n\n\n
                          5. Yamori W*, Hikosaka K, Way DA (2014) Temperature response of photosynthesis in C3, C4 and CAM plants: Temperature acclimation and temperature adaptation. Photosyn Res<\/em><\/strong>, 119: 101\u2013117.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n\n\n\n
                            <\/div>\n\n\n\n

                            B02-3\uff1a\u7d30\u80de\u8cea\u5171\u751f\u7d30\u83cc\u30dc\u30eb\u30d0\u30ad\u30a2\u306e\u30b2\u30ce\u30e0\u7de8\u96c6\u306b\u3088\u308b\u6027\u5236\u5fa1\u3068\u5171\u751f\u6a5f\u69cb\u306e\u89e3\u660e<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/h3>\n\n\n\n
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                            \"\"<\/figure>\n<\/div>\n\n\n\n
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                            \u6728\u5185 \u9686\u53f2<\/h4>\n\n\n\n

                            \u7814\u7a76\u4ee3\u8868\u8005
                            \u6771\u4eac\u5927\u5b66\u5927\u5b66\u9662\u8fb2\u5b66\u751f\u547d\u79d1\u5b66\u7814\u7a76\u79d1\u3000\u51c6\u6559\u6388
                            \u7814\u7a76\u5ba4HP<\/mark>\u3000https:\/\/sites.google.com\/view\/igblab-ut-aba\/top<\/a>
                            Researchmap<\/mark>\u3000                            https:\/\/researchmap.jp\/takashikiuchi\/?lang=japanese<\/a>
                            ORCID<\/mark>\u3000                            https:\/\/orcid.org\/0000-0003-3616-1650<\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n

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                            \u7814\u7a76\u5206\u62c5\u8005<\/h3>\n\n\n\n

                            \u5e84\u53f8\u4f73\u7950 (\u8fb2\u5de5\u5927\u30fbBASE\u30fb\u51c6\u6559\u6388\u30fb\u751f\u547d\u60c5\u5831\u79d1\u5b66\u30fb\u5206\u5b50\u751f\u7269\u5b66\u30fb\u7814\u7a76\u63a8\u9032\u3068\u60c5\u5831\u89e3\u6790)<\/p>\n\n\n\n

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                            \u5e84\u53f8 \u4f73\u7950<\/figcaption><\/figure>\n<\/div>\n\n\n\n
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                            \u8a73\u7d30\u3092\u898b\u308b<\/p>\n<\/span><\/div>\n\n\n\n

                            \n

                            \u7bc0\u8db3\u52d5\u7269\u306e\u7d04\u534a\u5206\u306b\u611f\u67d3\u3057\u3066\u3044\u308b\u3068\u3055\u308c\u308b\u5171\u751f\u7d30\u83cc\u30dc\u30eb\u30d0\u30ad\u30a2\u306f\u7d30\u80de\u5185\u306b\u304a\u3044\u3066\u30aa\u30eb\u30ac\u30cd\u30e9\u306e\u3088\u3046\u306b\u632f\u308b\u821e\u3044\u3001\u6bcd\u6027\u907a\u4f1d\u306b\u3088\u308a\u6b21\u4e16\u4ee3\u306b\u4f1d\u308f\u308b\u3002\u30dc\u30eb\u30d0\u30ad\u30a2\u306f\u81ea\u8eab\u306e\u611f\u67d3\u3092\u5bbf\u4e3b\u96c6\u56e3\u5185\u306b\u5e83\u3052\u308b\u305f\u3081\u306b\u3001\u30aa\u30b9\u3092\u7279\u7570\u7684\u306b\u81f4\u6b7b\u3055\u305b\u308b (\u30aa\u30b9\u6bba\u3057) \u306a\u3069\u3001\u5bbf\u4e3b\u306e\u6027\u3084\u751f\u6b96\u3092\u64cd\u4f5c\u3059\u308b\u3053\u3068\u304c\u3042\u308b\u3002\u307e\u305f\u3001\u30dc\u30eb\u30d0\u30ad\u30a2\u306b\u611f\u67d3\u3057\u305f\u868a\u306f\u30c7\u30f3\u30b0\u30a6\u30a4\u30eb\u30b9\u3084\u30de\u30e9\u30ea\u30a2\u306e\u5a92\u4ecb\u6027\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3002\u3053\u308c\u3089\u7279\u7570\u306a\u751f\u547d\u73fe\u8c61\u3092\u5fdc\u7528\u3057\u3001\u30dc\u30eb\u30d0\u30ad\u30a2\u3092\u7528\u3044\u305f\u6606\u866b\u5236\u5fa1\u6280\u8853\u304c\u8003\u6848\u3055\u308c\u3001\u4e00\u90e8\u306f\u3059\u3067\u306b\u5b9f\u65bd\u3055\u308c\u3066\u3044\u308b\u3002\u3057\u304b\u3057\u3001 \u30aa\u30eb\u30ac\u30cd\u30e9\u5316\u3057\u305f\u30dc\u30eb\u30d0\u30ad\u30a2\u306e\u7d30\u80de\u5916\u57f9\u990a\u3084\u79fb\u690d\u306f\u56f0\u96e3\u3067\u3001\u907a\u4f1d\u5b50\u64cd\u4f5c\u6280\u8853\u3082\u306a\u304f\u3001\u5171\u751f\u6a5f\u69cb (\u6bcd\u6027\u907a\u4f1d\u3084\u75c5\u539f\u4f53\u5a92\u4ecb\u6027\u306e\u4f4e\u4e0b\u306a\u3069) \u3084\u6027\u5236\u5fa1\u6a5f\u69cb\u306a\u3069\u3001\u30dc\u30eb\u30d0\u30ad\u30a2\u7279\u7570\u7684\u306a\u751f\u547d\u73fe\u8c61\u306e\u5b9f\u884c\u56e0\u5b50\u3084\u4f5c\u7528\u6a5f\u5e8f\u306f\u4e00\u90e8\u3092\u9664\u3044\u3066\u672a\u89e3\u660e\u3067\u3042\u308b\u3002\u305d\u3053\u3067\u672c\u7814\u7a76\u8ab2\u984c\u3067\u306f\u3001\u4e16\u754c\u521d\u3068\u306a\u308b\u30dc\u30eb\u30d0\u30ad\u30a2 (Wol) TALEN\u306e\u958b\u767a\u3092\u901a\u3058\u3066\u3001\u3053\u308c\u307e\u3067\u672a\u89e3\u660e\u3067\u3042\u3063\u305f\u30dc\u30eb\u30d0\u30ad\u30a2\u907a\u4f1d\u5b50\u306e\u6a5f\u80fd\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3002\u5c06\u6765\u7684\u306b\u306f\u3001\u30dc\u30eb\u30d0\u30ad\u30a2\u3092\u5229\u7528\u3057\u305f\u6606\u866b\u5236\u5fa1\u6280\u8853\u306e\u958b\u767a\u3092\u76ee\u6307\u3059\u3002\u305d\u306e\u305f\u3081\u306b\u3001\u4ee5\u4e0b\u306e3\u3064\u306e\u8ab2\u984c\u306b\u53d6\u308a\u7d44\u3080\u3002\u2460\u9818\u57df\u5185\u306e\u6280\u8853\u5354\u529b\u306e\u3082\u3068\u30dc\u30eb\u30d0\u30ad\u30a2\u5185\u306bTALEN\u3092\u8f38\u9001\u3059\u308b\u30b7\u30b9\u30c6\u30e0\u3092\u69cb\u7bc9\u3057\u3001WolTALEN\u306e\u958b\u767a\u3092\u76ee\u6307\u3059\u3002\u79c1\u305f\u3061\u304c\u540c\u5b9a\u3057\u305f\u30aa\u30b9\u6bba\u3057\u5b9f\u884c\u56e0\u5b50Oscar (Nat Commun<\/em><\/strong> 2022) \u3092\u6a19\u7684\u3068\u3057\u3001\u30aa\u30b9\u5316\u3068\u907a\u4f1d\u5b50\u91cf\u88dc\u511f\u3092\u62c5\u3046\u30bf\u30f3\u30d1\u30af\u8ceaMasc (Nature<\/em><\/strong> 2014) \u306e\u6a5f\u80fd\u5fa9\u5e30\u3092\u6307\u6a19\u3068\u3059\u308b\u3053\u3068\u3067\u30b2\u30ce\u30e0\u7de8\u96c6\u306e\u52b9\u679c\u3092\u8fc5\u901f\u306b\u8a55\u4fa1\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002\u2461\u30aa\u30eb\u30ac\u30cd\u30e9\u5316\u3057\u3064\u3064\u3042\u308b\u30dc\u30eb\u30d0\u30ad\u30a2\u306e\u6027\u5236\u5fa1\u3084\u5171\u751f\u6a5f\u69cb\u3092\u89e3\u660e\u3057\u3001\u305d\u308c\u3092\u5229\u7528\u3057\u305f\u5fdc\u7528\u5c55\u958b\u3092\u76ee\u6307\u3059\u3068\u3068\u3082\u306b\u3001\u30aa\u30eb\u30ac\u30cd\u30e9\u3067\u3042\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3084\u8449\u7dd1\u4f53\u3068\u6bd4\u8f03\u3059\u308b\u3053\u3068\u3067\u305d\u306e\u5171\u901a\u6027\u3084\u591a\u69d8\u6027\u306b\u3064\u3044\u3066\u9818\u57df\u5185\u306b\u304a\u3051\u308b\u8b70\u8ad6\u3092\u6d3b\u6027\u5316\u3057\u3001\u5171\u751f\u30aa\u30eb\u30ac\u30cd\u30e9\u5b66\u306e\u767a\u5c55\u306b\u8ca2\u732e\u3059\u308b\u3002\u9818\u57df\u306b\u304a\u3044\u3066\u7d30\u80de\u5185\u5171\u751f\u7d30\u83cc\u7814\u7a76\u3078\u306e\u6a4b\u6e21\u3057\u7684\u5f79\u5272\u3092\u62c5\u3044\u3001\u9818\u57df\u5185 (\u516c\u52df\u73ed) \u306bWolTALEN\u3092\u63d0\u4f9b\u3059\u308b\u3053\u3068\u3067\u3001\u7814\u7a76\u306e\u591a\u69d8\u6027\u3084\u6ce2\u53ca\u52b9\u679c\u3092\u751f\u307f\u51fa\u3059\u3002<\/p>\n\n\n\n

                            \"\"<\/figure>\n\n\n\n

                            \u7814\u7a76\u696d\u7e3e\u3000*\u8cac\u4efb\u8457\u8005<\/span><\/h3>\n\n\n\n
                              \n
                            1. Kiuchi T*, Katsuma S (2022) Functional characterization of silkworm PIWI proteins by embryonic RNAi. Methods Mol Biol<\/em><\/strong>, 2360: 19\u201331.<\/li>\n\n\n\n
                            2. Katsuma S*, Hirota K, Matsuda-Imai N, Fukui T, Muro T, Nishino K, Kosako H, Shoji K, Takanashi H, Fujii T, Arimura S, Kiuchi T (2022) A Wolbachia factor for male killing in lepidopteran insects. Nat Commun<\/em><\/strong>, 13: 6764.<\/li>\n\n\n\n
                            3. Cortes-Silva N, Ulmer J, Kiuchi T, Hsieh E, Cornilleau G, Ladid I, Dingli F, Loew D, Katsuma S, Drinnenberg IA* (2020) CenH3-independent kinetochore assembly in Lepidoptera requires CCAN, including CENPT. Curr Biol<\/em><\/strong>, 30: 561\u2013572.e10.<\/li>\n\n\n\n
                            4. Fukui T\u2020, Kawamoto M\u2020, Shoji K\u2020, Kiuchi T\u2020, Sugano S, Shimada T, Suzuki Y, Katsuma S* (2015) The endosymbiotic bacterium Wolbachia selectively kills male hosts by targeting the masculinizing gene. PLoS Pathogens<\/em><\/strong>, 11: e1005048. (\u2020contributed equally to this work)<\/li>\n\n\n\n
                            5. Kiuchi T, Koga H, Kawamoto M, Shoji K, Sakai H, Arai Y, Ishihara G, Kawaoka S, Sugano S, Shimada T, Suzuki Y, Suzuki MG, Katsuma S* (2014) A single female-specific piRNA is the primary determiner of sex in the silkworm. Nature<\/em><\/strong>, 509: 633\u2013636.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n\n\n\n
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                              B02-4\uff1a\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306b\u6f5c\u5728\u3059\u308b\u300c\u30aa\u30b9\u6bba\u3057\u300d\u30b7\u30b9\u30c6\u30e0\u306e\u89e3\u660e\u3068\u80b2\u7a2e\u3078\u306e\u5fdc\u7528<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/h3>\n\n\n\n
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                              \u98a8\u9593 \u667a\u5f66<\/h4>\n\n\n\n

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                              \u7814\u7a76\u5ba4HP<\/mark>\u3000https:\/\/www.agr.kyushu-u.ac.jp\/lab\/plantmb\/index.html<\/a>
                              Researchmap<\/mark>\u3000                              https:\/\/researchmap.jp\/read0143904\/?lang=japanese<\/a>
                              ORCID<\/mark>\u3000                              https:\/\/orcid.org\/0000-0003-3808-3991<\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n

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                              \u7814\u7a76\u5206\u62c5\u8005<\/h3>\n\n\n\n

                              \u9ce5\u5c71\u6b3d\u54c9 (\u6771\u5317\u5927\u30fb\u8fb2\u5b66\u30fb\u6559\u6388\u30fb\u690d\u7269\u5206\u5b50\u80b2\u7a2e\u5b66\u30fb\u907a\u4f1d\u89e3\u6790\u3068\u30c7\u30fc\u30bf\u89e3\u6790)<\/p>\n\n\n\n

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                              \u8a73\u7d30\u3092\u898b\u308b<\/p>\n<\/span><\/div>\n\n\n\n

                              \n

                              \u7d30\u80de\u8cea\u30b2\u30ce\u30e0\u304c\u3064\u304b\u3055\u3069\u308b\u751f\u547d\u73fe\u8c61\u306e\u89e3\u660e\u3068\u91cd\u8981\u5f62\u8cea\u306e\u6539\u826f\u3092\u76ee\u6307\u3057\u3066\u3001\u690d\u7269\u306e\u7d30\u80de\u8cea\u30b2\u30ce\u30e0\u3001\u7279\u306b\u8fd1\u5e74\u898b\u51fa\u3057\u305f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u30b2\u30ce\u30e0\u306b\u6f5c\u5728\u3059\u308b\u82b1\u7c89\u767a\u9054\u963b\u5bb3\u3092\u5f15\u304d\u8d77\u3053\u3059\u65b0\u898f\u300c\u30aa\u30b9\u6bba\u3057\u300d\u30b7\u30b9\u30c6\u30e0\u306e\u89e3\u660e\u3068\u3053\u308c\u3092\u5fdc\u7528\u3057\u305f\u65b0\u898fF1\u63a1\u7a2e\u30b7\u30b9\u30c6\u30e0\u306e\u78ba\u7acb\u306b\u6311\u6226\u3059\u308b\u3002\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u30b2\u30ce\u30e0\u3078\u306e\u7cbe\u5bc6\u5909\u7570\u5c0e\u5165 (mitoTALECD) \u3084\u907a\u4f1d\u5b50\u7834\u58ca (mitoTALEN) \u3092\u7528\u3044\u3066\u3001\u2460\u672a\u3060\u306b\u6a5f\u80fd\u306e\u5206\u304b\u3063\u3066\u3044\u306a\u3044\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u907a\u4f1d\u5b50\u306e\u6a5f\u80fd\u3092\u660e\u3089\u304b\u306b\u3059\u308b (\u6709\u6751\u73ed\u3068\u5354\u50cd)\u3002\u307e\u305f\u3001\u2461\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u5236\u5fa1\u306b\u95a2\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u6838\u907a\u4f1d\u5b50\u3092\u660e\u3089\u304b\u306b\u3057\u3001\u305d\u306e\u5236\u5fa1\u6a5f\u69cb\u3092\u660e\u3089\u304b\u306b\u3059\u308b (\u7af9\u4e2d\u73ed\u3068\u5354\u50cd)\u3002\u3055\u3089\u306b\u3001\u2460\u3068\u2461\u3088\u308a\u660e\u3089\u304b\u306b\u306a\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u30fb\u6838\u907a\u4f1d\u5b50\u306e\u7d44\u307f\u5408\u308f\u305b\u3092\u4eba\u70ba\u7684\u306b\u5236\u5fa1\u3059\u308b\u3053\u3068\u3067\u3001\u2462\u30b2\u30ce\u30e0\u7de8\u96c6\u3067\u300c\u30aa\u30b9\u6bba\u3057\u300d\u690d\u7269\u3092\u65b0\u898f\u306b\u4f5c\u51fa\u3059\u308b\u3002\u3053\u308c\u3089\u306e\u904e\u7a0b\u3067\u3001\u300c\u30aa\u30b9\u6bba\u3057\u300d\u907a\u4f1d\u5b50\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u305f\u3081\u306b\u5fc5\u9808\u306a\u914d\u5217\u6761\u4ef6\u304c\u660e\u3089\u304b\u306b\u306a\u308c\u3070\u3001\u4eba\u70ba\u7684\u306b\u300c\u30aa\u30b9\u6bba\u3057\u300d\u907a\u4f1d\u5b50\u304c\u5408\u6210\u3067\u304d\u308b\u3002\u5408\u6210\u3057\u305f\u4eba\u5de5\u300c\u30aa\u30b9\u6bba\u3057\u300d\u907a\u4f1d\u5b50\u3092\u30aa\u30eb\u30ac\u30cd\u30e9\u907a\u4f1d\u5b50\u5c0e\u5165\u6280\u8853\u306b\u3088\u3063\u3066\u5c0e\u5165 (\u6cbc\u7530\u73ed\u3068\u5354\u50cd) \u3059\u308b\u3053\u3068\u3067\u907a\u4f1d\u8cc7\u6e90\u306b\u983c\u3089\u306a\u3044\u300c\u30aa\u30b9\u6bba\u3057\u300d\u690d\u7269\u306e\u4f5c\u51fa\u304c\u53ef\u80fd\u3068\u306a\u308b\u3002\u307e\u305f\u3001\u660e\u3089\u304b\u306b\u3057\u305f\u6210\u679c\u3092\u4ed6\u306e\u690d\u7269\u3078\u3068\u5fdc\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u300c\u30aa\u30b9\u6bba\u3057\u300d\u304c\u5f97\u3089\u308c\u3066\u3044\u306a\u3044\u690d\u7269\u3067\u306e\u300c\u30aa\u30b9\u6bba\u3057\u300d\u690d\u7269\u306e\u4f5c\u51fa\u304c\u53ef\u80fd\u306b\u306a\u308a\u3001\u3053\u308c\u306f\u52b9\u7387\u7684\u306aF1\u7a2e\u5b50\u751f\u7523\u306a\u3069\u5546\u696d\u7684\u306a\u4fa1\u5024\u304c\u9ad8\u3044\u5f62\u8cea\u3067\u3042\u308b\u3002\u3053\u306e\u3088\u3046\u306b\u3001\u65e5\u672c\u767a\u306e\u6280\u8853\u3092\u5229\u7528\u3057\u3066\u30aa\u30eb\u30ac\u30cd\u30e9\u80b2\u7a2e\u307e\u3067\u306e\u5fdc\u7528\u304c\u53ef\u80fd\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3059\u3002\u3055\u3089\u306b\u3001 \u30dc\u30eb\u30d0\u30ad\u30a2\u306b\u3088\u308b\u30aa\u30b9\u6bba\u3057\u6a5f\u69cb (\u6728\u5185\u73ed\u3068\u5354\u50cd) \u3068\u6bd4\u8f03\u3059\u308b\u3053\u3068\u3067\u690d\u7269\u306b\u304a\u3051\u308b\u300c\u30aa\u30b9\u6bba\u3057\u300d\u306e\u751f\u7269\u5b66\u7684\u306a\u610f\u7fa9\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3002<\/p>\n\n\n\n

                              \"\"<\/figure>\n\n\n\n

                              \u7814\u7a76\u696d\u7e3e\u3000*\u8cac\u4efb\u8457\u8005<\/span><\/h3>\n\n\n\n
                                \n
                              1. Takatsuki A, Kazama T, Arimura SI, Toriyama K* (2022) TALEN-mediated depletion of the mitochondrial gene orf312 proves that it is a Tadukan-type cytoplasmic male sterility-causative gene in rice. Plant J<\/em><\/strong>, 110: 994\u20131004.<\/li>\n\n\n\n
                              2. Omukai S, Arimura SI, Toriyama K, Kazama T* (2021) Disruption of mitochondrial open reading frame 352 partially restores pollen development in cytoplasmic male sterile rice. Plant Physiol<\/em><\/strong>, 187: 236\u2013246.<\/li>\n\n\n\n
                              3. Kazama T*, Okuno M, Watari Y, Yanase S, Koizuka C, Tsuruta Y, Sugaya H, Toyoda A, Itoh T, Tsutsumi N, Toriyama K, Koizuka N*, Arimura SI* (2019) Curing cytoplasmic male sterility via TALEN-mediated mitochondrial genome editing. Nat Plants<\/em><\/strong>, 5: 722\u2013730.<\/li>\n\n\n\n
                              4. Kazama T*, Itabashi E, Fujii S, Nakamura T, Toriyama K (2016) Mitochondrial ORF79 levels determine pollen abortion in cytoplasmic male sterile rice. Plant J<\/em><\/strong>, 85, 707\u2013716.<\/li>\n\n\n\n
                              5. Kazama T, Toriyama K* (2003) A pentatricopeptide repeat-containing gene that promotes the processing of aberrant atp6 RNA of cytoplasmic male-sterile rice. FEBS Lett<\/em><\/strong>, 544: 99\u2013102.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n\n\n\n
                                <\/div>\n\n\n\n

                                \u516c\u52df\u73ed<\/h2>\n\n\n\n

                                B02-5\uff1a\u6c17\u5b54\u7d30\u80de\u306b\u304a\u3051\u308b\u8449\u7dd1\u4f53\u30b2\u30ce\u30e0\u907a\u4f1d\u5b50\u5236\u5fa1\u306e\u751f\u7406\u5b66\u7684\u610f\u7fa9\u306e\u89e3\u660e<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/h3>\n\n\n\n
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                                \"\"<\/figure>\n<\/div>\n\n\n\n
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                                \u7962\u519d \u6df3\u592a\u90ce<\/h4>\n\n\n\n

                                \u7814\u7a76\u4ee3\u8868\u8005
                                \u4e5d\u5dde\u5927\u5b66\u30fb\u7406\u5b66\u7814\u7a76\u9662\u3000\u6559\u6388
                                \u7814\u7a76\u5ba4HP<\/mark>\u3000http:\/\/www.biology.kyushu-u.ac.jp\/~plant\/index.html<\/a>
                                Researchmap<\/mark>\u3000                                https:\/\/researchmap.jp\/juntaro-negi<\/a>
                                ORCID<\/mark>\u3000                                https:\/\/orcid.org\/0000-0001-7457-1269<\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n

                                <\/div><\/div>\n\n\n\n
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                                \u8a73\u7d30\u3092\u898b\u308b<\/p>\n<\/span><\/div>\n\n\n\n

                                \n

                                \u690d\u7269\u72ec\u81ea\u306e\u30aa\u30eb\u30ac\u30cd\u30e9\u3067\u3042\u308b\u8449\u7dd1\u4f53\u306f\u3001\u7d44\u7e54\u3054\u3068\u306b\u5f62\u614b\u3084\u6a5f\u80fd\u3092\u5909\u5316\u3055\u305b\u3001\u690d\u7269\u306e\u751f\u7406\u6210\u9577\u3092\u652f\u3048\u3066\u3044\u308b\u3002\u8449\u8089\u7d30\u80de\u306e\u8449\u7dd1\u4f53\u306f\u5149\u5408\u6210\u6a5f\u80fd\u306b\u7279\u5316\u3057\u3066\u3044\u308b\u306e\u306b\u5bfe\u3057\u3066\u3001\u8868\u76ae\u7d44\u7e54\u306e\u8449\u7dd1\u4f53\u306f\u5149\u5408\u6210\u6a5f\u80fd\u3092\u6291\u3048\u3066\u3001\u74b0\u5883\u60c5\u5831\u51e6\u7406\u88c5\u7f6e\u3068\u3057\u3066\u306e\u6a5f\u80fd\u3092\u5f37\u5316\u3055\u305b\u3066\u3044\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u3064\u3064\u3042\u308b\uff08Negi et al. PNAS 2018: Obata et al. \u672a\u767a\u8868\uff09\u3002\u305d\u306e\u9055\u3044\u3092\u751f\u307f\u51fa\u3059\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u307e\u3060\u5206\u304b\u3063\u3066\u3044\u306a\u3044\u304c\u3001\u6211\u3005\u306f\u6700\u8fd1\u3001\u6c17\u5b54\u8449\u7dd1\u4f53\u3068\u8449\u8089\u8449\u7dd1\u4f53\u3092\u7528\u3044\u305f\u5b9a\u91cf\uff08DIA\uff09\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u6bd4\u8f03\u89e3\u6790\u304b\u3089\u3001\uff12\u3064\u306e\u8449\u7dd1\u4f53\u306e\u9593\u3067\u8449\u7dd1\u4f53\u30b2\u30ce\u30e0\u30b3\u30fc\u30c9\u907a\u4f1d\u5b50\u306e\u30bf\u30f3\u30d1\u30af\u767a\u73fe\u91cf\u304c\u7570\u306a\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u305f\u3002\u305d\u3053\u3067\u3001\u672c\u7814\u7a76\u3067\u306f\u6c17\u5b54\uff08\u5b54\u8fba\uff09\u7d30\u80de\u7279\u7570\u7684\u306b\u8449\u7dd1\u4f53\u30b2\u30ce\u30e0\u306b\u5909\u7570\u5c0e\u5165\u3059\u308b\u3053\u3068\u3067\u3001\u6c17\u5b54\u7d30\u80de\u304c\u4fdd\u6301\u3059\u308b\u8449\u7dd1\u4f53\u30b2\u30ce\u30e0\u907a\u4f1d\u5b50\u304c\u6c17\u5b54\u958b\u9589\u5236\u5fa1\u306b\u304a\u3044\u3066\u679c\u305f\u3059\u5f79\u5272\u3092\u660e\u3089\u304b\u306b\u3057\u3001\u690d\u7269\u7d44\u7e54\u3054\u3068\u306b\u8449\u7dd1\u4f53\u30b2\u30ce\u30e0\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u91cf\u3092\u30ab\u30b9\u30bf\u30de\u30a4\u30ba\u3059\u308b\u751f\u7406\u5b66\u7684\u306a\u610f\u7fa9\u306b\u8feb\u308b\u3002<\/p>\n\n\n\n

                                \"\"<\/figure>\n\n\n\n

                                \u7814\u7a76\u696d\u7e3e\u3000*\u8cac\u4efb\u8457\u8005<\/span><\/h3>\n\n\n\n
                                  \n
                                1. Negi J*, Munemasa S, Song B, Tadakuma R, Fujita M, Azoulay-Shemer T, Engineer CB, Kusumi K, Nishida I, Schroeder JI, Iba K*<\/strong> (2018) Eukaryotic lipid metabolic pathway is essential for functional chloroplasts and CO2<\/sub> and light responses in Arabidopsis<\/em> guard cells. Proc Natl Acad Sci USA <\/em><\/strong>115: 9038-9043. <\/em><\/strong><\/li>\n\n\n\n
                                2. Negi J, Moriwaki K, Konishi M, Yokoyama R, Nakano T, Kusumi K, Hashimoto-Sugimoto M, Schroeder JI, Nishitani K, Yanagisawa S, Iba K*<\/strong> (2013) A Dof transcription factor, SCAP1, is essential for the development of functional stomata in Arabidopsis<\/em>. Curr Biol<\/em><\/strong> 23: 479-484.<\/li>\n\n\n\n
                                3. Negi J, Matsuda O, Nagasawa T, Oba Y, Takahashi H, Kawai-Yamada M, Uchimiya H, Hashimoto M, Iba, K*<\/strong> (2008) CO2 <\/sub>regulator SLAC1 and its homologues are essential for anion homeostasis in plant cells. Nature<\/em><\/strong> 452: 483-486.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n\n\n\n
                                  <\/div>\n\n\n\n

                                  B02-6\uff1a\u5171\u751f\u7d30\u83cc\u30dc\u30eb\u30d0\u30ad\u30a2\u306e\u30b2\u30ce\u30e0\u64cd\u4f5c\u306b\u3088\u308b\u907a\u4f1d\u5b50\u6a5f\u80fd\u89e3\u6790\u3068\u65b0\u898f\u7cfb\u7d71\u306e\u4f5c\u51fa<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/h3>\n\n\n\n
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                                  \u5927\u624b \u5b66<\/h4>\n\n\n\n

                                  \u7814\u7a76\u4ee3\u8868\u8005
                                  \u6771\u4eac\u6148\u6075\u4f1a\u533b\u79d1\u5927\u5b66\u30fb\u533b\u5b66\u90e8\u3000\u8b1b\u5e2b
                                  \u7814\u7a76\u5ba4HP<\/mark>\u3000http:\/\/jikei-tropmed.jp\/<\/a>
                                  Researchmap<\/mark>\u3000                                  https:\/\/researchmap.jp\/wolbachia<\/a>
                                  ORCID<\/mark>\u3000                                  https:\/\/orcid.org\/0000-0003-1480-0319<\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n

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                                  \u8a73\u7d30\u3092\u898b\u308b<\/p>\n<\/span><\/div>\n\n\n\n

                                  \n

                                  \u6606\u866b\u306e\u7d30\u80de\u5185\u5171\u751f\u7d30\u83cc\u3067\u3042\u308b\u30dc\u30eb\u30d0\u30ad\u30a2\u306f\u3001\u5bbf\u4e3b\u306b\u5bfe\u3057\u3066\u30e1\u30b9\u5316\u3084\u30aa\u30b9\u6bba\u3057\u3001\u7d30\u80de\u8cea\u4e0d\u548c\u5408\u6027\u306a\u3069\u306e\u6027\u6bd4\u30fb\u751f\u6b96\u64b9\u4e71\u3001\u304a\u3088\u3073RNA\u30a6\u30a4\u30eb\u30b9\u8010\u6027\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3002\u3053\u308c\u3089\u306e\u73fe\u8c61\u306f\u3001\u30dc\u30eb\u30d0\u30ad\u30a2\u306e\u30b2\u30ce\u30e0\u306b\u30b3\u30fc\u30c9\u3055\u308c\u305f\u907a\u4f1d\u5b50\u7fa4\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u3002\u3057\u304b\u3057\u3001\u30dc\u30eb\u30d0\u30ad\u30a2\u306b\u5bfe\u3059\u308b\u907a\u4f1d\u5b50\u64cd\u4f5c\u6280\u8853\u306f\u672a\u3060\u78ba\u7acb\u3055\u308c\u3066\u304a\u3089\u305a\u3001\u305d\u306e\u5bbf\u4e3b\u64cd\u4f5c\u6a5f\u69cb\u306e\u89e3\u660e\u306f\u5341\u5206\u3068\u306f\u8a00\u3044\u96e3\u3044\u3002
                                  \u672c\u7814\u7a76\u3067\u306f\u3001\u4ed6\u306e\u7d30\u80de\u5185\u5bc4\u751f\u30fb\u5171\u751f\u7d30\u83cc\u306b\u3082\u5fdc\u7528\u53ef\u80fd\u306a\u3001\u5bbf\u4e3b\u7d30\u80de\u5185\u3067\u30dc\u30eb\u30d0\u30ad\u30a2\u907a\u4f1d\u5b50\u3092\u7834\u58ca\u3059\u308b\u6280\u8853\u3092\u958b\u767a\u3059\u308b\u3002\u3053\u306e\u6280\u8853\u3092\u7528\u3044\u3066\u3001\u7533\u8acb\u8005\u304c\u540c\u5b9a\u3057\u305f\u30dc\u30eb\u30d0\u30ad\u30a2\u907a\u4f1d\u5b50\u3092\u7834\u58ca\u3059\u308b\u3053\u3068\u3067\u3001\u30dc\u30eb\u30d0\u30ad\u30a2\u306b\u3088\u308b\u5bbf\u4e3b\u306e\u598a\u6027\u5897\u5f37\u3084RNA\u30a6\u30a4\u30eb\u30b9\u62b5\u6297\u6027\u4ed8\u4e0e\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u89e3\u660e\u3059\u308b\u3002\u307e\u305f\u3001\u30ea\u30b1\u30c3\u30c1\u30a2\u306a\u3069\u3067\u78ba\u7acb\u3055\u308c\u305f\u624b\u6cd5\u3092\u5fdc\u7528\u3057\u3001\u30dc\u30eb\u30d0\u30ad\u30a2\u3078\u5916\u6765\u907a\u4f1d\u5b50\u3092\u5c0e\u5165\u3059\u308b\u6280\u8853\u3092\u958b\u767a\u3059\u308b\u3053\u3068\u3067\u3001\u611f\u67d3\u75c7\u3092\u5a92\u4ecb\u3057\u306a\u3044\u868a\u306e\u7cfb\u7d71\u6a39\u7acb\u3092\u76ee\u7684\u3068\u3057\u305f\u65b0\u898f\u306e\u30dc\u30eb\u30d0\u30ad\u30a2\u7cfb\u7d71\u3092\u4f5c\u51fa\u3059\u308b\u3002
                                  \u3053\u308c\u3089\u4e00\u9023\u306e\u30b2\u30ce\u30e0\u64cd\u4f5c\u6280\u8853\u306e\u958b\u767a\u3068\u5fdc\u7528\u306b\u3088\u308a\u3001\u7d30\u80de\u5185\u5171\u751f\u7d30\u83cc\u306b\u304a\u3051\u308b\u5171\u751f\u7cfb\u306e\u9032\u5316\u3084\u591a\u69d8\u6027\u306b\u95a2\u3059\u308b\u65b0\u305f\u306a\u77e5\u898b\u304c\u5f97\u3089\u308c\u308b\u3068\u3068\u3082\u306b\u3001\u9769\u65b0\u7684\u306a\u6606\u866b\u5236\u5fa1\u6280\u8853\u306e\u57fa\u76e4\u304c\u69cb\u7bc9\u3055\u308c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u308b\u3002<\/p>\n\n\n\n

                                  \"\"<\/figure>\n\n\n\n

                                  \u7814\u7a76\u696d\u7e3e\u3000*\u8cac\u4efb\u8457\u8005<\/span><\/h3>\n\n\n\n
                                    \n
                                  1. Ote M, Yamamoto D* (2020) Impact of Wolbachia infection on Drosophila female germline stem cells. Curr Opin Insect Sci<\/em><\/strong>, 37:8-15.<\/li>\n\n\n\n
                                  2. Ote M, Yamamoto D* (2018) The Wolbachia protein TomO interacts with a host RNA to induce polarization defects in Drosophila oocytes. Arch Insect Biochem Physiol<\/em><\/strong>, 99:e21475.<\/li>\n\n\n\n
                                  3. Ote M, Ueyama M, Yamamoto D* (2016) Wolbachia Protein TomO Targets nanos mRNA and Restores Germ Stem Cells in Drosophila Sex-lethal Mutants. Curr Biol<\/em><\/strong>, 26:2223-2232.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n\n\n\n
                                    <\/div>\n\n\n\n

                                    B02-7\uff1aiPS\u7d30\u80de\u3092\u7528\u3044\u305f\u5909\u7570mtDNA\u306b\u8d77\u56e0\u3059\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u75c5\u306e\u75c5\u614b\u89e3\u6790<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/h3>\n\n\n\n
                                    \n
                                    \n
                                    \"\"<\/figure>\n<\/div>\n\n\n\n
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                                    <\/div><\/div>\n\n\n\n

                                    \u516b\u5e61 \u76f4\u6a39<\/h4>\n\n\n\n

                                    \u7814\u7a76\u4ee3\u8868\u8005
                                    \u85e4\u7530\u533b\u79d1\u5927\u5b66\u30fb\u533b\u5b66\u90e8\u3000\u8b1b\u5e2b
                                    \u7814\u7a76\u5ba4HP<\/mark>\u3000https:\/\/www.fujita-hu.ac.jp\/graduate\/medical\/laboratories\/developmental_neurobiology.html<\/a>
                                    Researchmap<\/mark>\u3000                                    https:\/\/researchmap.jp\/ko60_KE01sh1<\/a>
                                    ORCID<\/mark>\u3000                                    https:\/\/orcid.org\/0000-0003-4125-4536<\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n

                                    <\/div><\/div>\n\n\n\n
                                    \n
                                    \n

                                    \u8a73\u7d30\u3092\u898b\u308b<\/p>\n<\/span><\/div>\n\n\n\n

                                    \n

                                    \u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA(mtDNA)\u306e\u5909\u7570\u304c\u539f\u56e0\u3067\u767a\u75c7\u3059\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u75c5\u306e\u75c5\u614b\u89e3\u660e\u304a\u3088\u3073\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u3092\u76ee\u6307\u3057\u3001\u60a3\u8005\u7531\u6765iPS\u7d30\u80de\u3092\u7528\u3044\u305f\u75c5\u614b\u30e2\u30c7\u30eb\u306e\u4f5c\u51fa\u3092\u884c\u3046\u3002\u3053\u308c\u307e\u3067\u3001\u5909\u7570mtDNA\u306e\u5272\u5408\u3068\u75c5\u614b\u306e\u56e0\u679c\u95a2\u4fc2\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u305f\u3081\u306b\u3001iPS\u7d30\u80de\u306b\u304a\u3044\u3066mtDNA\u5909\u7570\u7387\u3092\u6539\u5909\u3067\u304d\u308b\u30b2\u30ce\u30e0\u7de8\u96c6\u30c4\u30fc\u30eb(mpTALEN)\u306e\u958b\u767a\u3092\u884c\u3063\u3066\u304d\u305f\u3002\u3053\u308c\u3089\u3092\u99c6\u4f7f\u3057\u3001\u69d8\u3005\u306a\u5909\u7570\u7387\u3092\u6709\u3059\u308biPS\u7d30\u80de\u3092\u4f5c\u88fd\u3057\u3001\u75c5\u614b\u304c\u73fe\u308c\u308b\u7d30\u80de\u3078\u5206\u5316\u8a98\u5c0e\u3092\u884c\u3044\u3001\u6bd4\u8f03\u89e3\u6790\u3092\u884c\u3046\u3002\u7279\u306b\u3053\u308c\u307e\u3067\u89e3\u6790\u304c\u96e3\u3057\u304b\u3063\u305f\u30d2\u30c8\u306e\u30cb\u30e5\u30fc\u30ed\u30f3\u3078\u306e\u5206\u5316\u8a98\u5c0e\u3092\u884c\u3044\u3001\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u6210\u719f\u904e\u7a0b\u306b\u304a\u3051\u308bmtDNA\u306e\u52d5\u614b\u3092\u89e3\u6790\u3057\u3001\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u5f62\u614b\u5909\u5316\u3068mtDNA\u306e\u52d5\u614b\u3068\u306e\u56e0\u679c\u95a2\u4fc2\u306e\u89e3\u660e\u3092\u76ee\u6307\u3059\u3002\u5909\u7570mtDNA\u304c\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u6210\u719f\u2015\u7834\u7dbb\u306b\u3069\u306e\u3088\u3046\u306b\u95a2\u4e0e\u3059\u308b\u304b\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u306f\u3001\u795e\u7d4c\u75c5\u614b\u767a\u75c7\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u7406\u89e3\u304a\u3088\u3073\u3001\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u306b\u8ca2\u732e\u3059\u308b\u3068\u8003\u3048\u308b\u3002<\/p>\n\n\n\n

                                    \"\"<\/figure>\n\n\n\n

                                    \u7814\u7a76\u696d\u7e3e\u3000*\u8cac\u4efb\u8457\u8005<\/span><\/h3>\n\n\n\n
                                      \n
                                    1. Yahata N*, Goto Y, Hata R* (2025) Optimization of mtDNA-targeted platinum TALENs for bi-directionally modifying heteroplasmy levels in patient-derived m.3243A>G-iPSCs. Mol Ther Nucleic Acids<\/em><\/strong>, 36: 102521.<\/li>\n\n\n\n
                                    2. Yahata N*, Boda H, Hata R* (2021) Elimination of Mutant mtDNA by an Optimized mpTALEN Restores Differentiation Capacities of Heteroplasmic MELAS-iPSCs. Mol Ther Methods Clin Dev<\/em><\/strong>, 20: 54\u201368.<\/li>\n\n\n\n
                                    3. Yahata N, Matsumoto Y, Omi M, Yamamoto N, Hata R* (2017) TALEN-mediated shift of mitochondrial DNA heteroplasmy in MELAS-iPSCs with m.13513G>A mutation. Sci Rep<\/em><\/strong>, 7: 15557.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n\n\n\n
                                      <\/div>\n\n\n\n

                                      B02-8\uff1a\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u30b2\u30ce\u30e0\u7de8\u96c6\u6280\u8853\u304c\u62d3\u304f\u75be\u60a3\u6cbb\u7642\u306e\u65b0\u5c55\u958b<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/h3>\n\n\n\n
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                                      \"\"<\/figure>\n<\/div>\n\n\n\n
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                                      \u8c37 \u6625\u83dc<\/h4>\n\n\n\n

                                      \u7814\u7a76\u4ee3\u8868\u8005
                                      \u6771\u5317\u5927\u5b66\u30fb\u52a0\u9f62\u533b\u5b66\u7814\u7a76\u6240\u3000\u52a9\u6559
                                      \u7814\u7a76\u5ba4HP<\/mark>\u3000https:\/\/www.modomics-medicine.com\/<\/a>
                                      Researchmap<\/mark>\u3000                                      https:\/\/researchmap.jp\/70930303<\/a>
                                      ORCID<\/mark>\u3000                                      https:\/\/orcid.org\/0009-0006-1277-8145<\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n

                                      <\/div><\/div>\n\n\n\n
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                                      \u8a73\u7d30\u3092\u898b\u308b<\/p>\n<\/span><\/div>\n\n\n\n

                                      \n

                                      \u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA (mtDNA) \u306b\u751f\u3058\u308b\u75c5\u539f\u6027\u5909\u7570\u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5185\u3067\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u7523\u751f\u4e0d\u5168\u3092\u4ecb\u3057\u3066\u3001\u8133\u5352\u4e2d\u69d8\u767a\u4f5c\u3001\u7b4b\u529b\u4f4e\u4e0b\u3001\u5fc3\u4e0d\u5168\u306a\u3069\u591a\u69d8\u306a\u75c7\u72b6\u3092\u5448\u3059\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u75c5\u306e\u539f\u56e0\u3068\u306a\u308b\u3002\u672c\u7814\u7a76\u3067\u306f\u3001\u3053\u3046\u3057\u305fmtDNA\u5909\u7570\u306b\u8d77\u56e0\u3059\u308b\u75be\u60a3\u306b\u5bfe\u3057\u3001mtDNA\u5869\u57fa\u7de8\u96c6\u6280\u8853\u3092\u5fdc\u7528\u3057\u305f\u6839\u672c\u7684\u306a\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u306b\u6311\u6226\u3059\u308b\u3002\u307e\u305a\u3001\u2460\u60a3\u8005\u7531\u6765\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u75c5\u30e2\u30c7\u30eb\u7d30\u80de\u3092\u7528\u3044\u3066\u3001\u75c5\u7684\u5909\u7570\u306e\u4fee\u6b63\u3068\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u306e\u6539\u5584\u3092\u691c\u8a3c\u3057\u3001\u6cbb\u7642\u6cd5\u3068\u3057\u3066\u306e\u57fa\u76e4\u3092\u78ba\u7acb\u3059\u308b\u3002\u6b21\u306b\u3001\u2461\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u75c5\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u306b\u5bfe\u3057\u3066mtDNA\u7de8\u96c6\u30c4\u30fc\u30eb\u3092\u751f\u4f53\u5185\u306b\u5c0e\u5165\u3059\u308b\u3053\u3068\u3067\u3001in vivo\u3067\u306e\u6cbb\u7642\u52b9\u679c\u3068\u5b89\u5168\u6027\u3092\u8a55\u4fa1\u3059\u308b\u3002\u3055\u3089\u306b\u3001\u2462mtDNA\u7de8\u96c6\u306e\u904e\u7a0b\u3067\u751f\u3058\u305f\u5869\u57fa\u7f6e\u63db\u3092\u6d3b\u7528\u3057\u3001\u75c5\u614b\u306e\u91cd\u75c7\u5ea6\u3084\u81e8\u5e8a\u7684\u591a\u69d8\u6027\u3092\u5de6\u53f3\u3059\u308b\u65b0\u898f\u6a5f\u80fd\u6027\u30d0\u30ea\u30a2\u30f3\u30c8\u306e\u540c\u5b9a\u3092\u8a66\u307f\u308b\u3002\u4ee5\u4e0a\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u901a\u3058\u3066\u3001\u3053\u308c\u307e\u3067\u6839\u6cbb\u304c\u4e0d\u53ef\u80fd\u3067\u3042\u3063\u305f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u75c5\u306b\u5bfe\u3059\u308bmtDNA\u7de8\u96c6\u6280\u8853\u306e\u81e8\u5e8a\u5fdc\u7528\u306b\u5411\u3051\u305f\u6280\u8853\u7684\u57fa\u76e4\u3092\u69cb\u7bc9\u3057\u3001\u5c06\u6765\u7684\u306b\u306f\u500b\u5225\u5316\u533b\u7642\u306e\u9ad8\u5ea6\u5316\u306b\u8ca2\u732e\u3059\u308b\u65b0\u305f\u306a\u6cbb\u7642\u6226\u7565\u306e\u63d0\u6848\u3092\u76ee\u6307\u3059\u3002<\/p>\n\n\n\n

                                      \"\"<\/figure>\n\n\n\n

                                      \u7814\u7a76\u696d\u7e3e\u3000*\u8cac\u4efb\u8457\u8005<\/span><\/h3>\n\n\n\n
                                        \n
                                      1. Tani H, Ishikawa K, Tamashiro H, Ogasawara E, Yasukawa T, Matsuda S, Shimizu A, Kang D, Hayashi J-I, Wei F-Y, Kazuto Nakada* (2022) Accumulation of mitochondrial DNA with a point mutation in tRNALeu (UUR)<\/sup> gene induces brain dysfunction in mice. Nucleic Acids Res. <\/em><\/strong>50: 9382-9396.<\/li>\n\n\n\n
                                      2. Tani H, Mito T, Velagapudi V, Ishikawa K, Umehara M, Nakada K, Suomalainen A, Hayashi J-I* (2019) Disruption of the mouse Shmt2 gene confers embryonic anaemia via foetal liver-specific metabolomic disorders. Scientific Reports<\/em><\/strong> 16054.<\/li>\n\n\n\n
                                      3. Tani H, Ohnishi S, Shitara H, Mito T, Yamaguchi M, Yonekawa H, Hashizume O, Ishikawa K, Nakada K, Hayashi J-I* (2018) Mice deficient in the Shmt2 gene have mitochondrial respiration defects and are embryonic lethal. Scientific Reports<\/em><\/strong> 425.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n\n\n\n
                                        <\/div>\n\n\n\n

                                        B02-9\uff1a\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u54c1\u8cea\u7ba1\u7406\u306e\u6d3b\u6027\u5316\u306b\u3088\u308b\u5909\u7570\u578bmtDNA\u306e\u5236\u5fa1\u6280\u8853\u69cb\u7bc9<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/h3>\n\n\n\n
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                                        \u8d64\u7fbd \u3057\u304a\u308a<\/h4>\n\n\n\n

                                        \u7814\u7a76\u4ee3\u8868\u8005
                                        \u795e\u5948\u5ddd\u770c\u7acb\u304c\u3093\u30bb\u30f3\u30bf\u30fc\u30fb\u81e8\u5e8a\u7814\u7a76\u6240\u304c\u3093\u751f\u7269\u5b66\u90e8\u3000\u4e3b\u4efb\u7814\u7a76\u54e1
                                        \u7814\u7a76\u5ba4HP<\/mark>\u3000https:\/\/kcch.kanagawa-pho.jp\/kccri\/organization\/cancerbiology.html<\/a>
                                        Researchmap<\/mark>\u3000                                        https:\/\/researchmap.jp\/7000020098<\/a>
                                        ORCID<\/mark>\u3000                                        https:\/\/orcid.org\/0009-0009-9088-0606<\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n

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                                        \u8a73\u7d30\u3092\u898b\u308b<\/p>\n<\/span><\/div>\n\n\n\n

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                                        \u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA\uff08mtDNA\uff09\u306e\u5909\u7570\u306e\u84c4\u7a4d\u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u75c5\u3084\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u767a\u75c7\u539f\u56e0\u3068\u306a\u308a\u3001\u304c\u3093\u60aa\u6027\u5316\u306b\u3082\u5bc6\u63a5\u306b\u95a2\u4fc2\u3059\u308b\u304c\u3001\u7d30\u80de\u5185\u3067\u5909\u7570\u578bmtDNA\u304c\u9ad8\u3044\u5272\u5408\u3067\u84c4\u7a4d\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u3084\u75be\u60a3\u767a\u75c7\u3068\u306e\u95a2\u4fc2\u306b\u3064\u3044\u3066\u8a73\u7d30\u306f\u660e\u3089\u304b\u3067\u306f\u306a\u3044\u3002\u672c\u7814\u7a76\u3067\u306f\u4ee5\u4e0b\u306e2\u3064\u306e\u8ab2\u984c\u306b\u53d6\u308a\u7d44\u307f\u3001\u5909\u7570\u578bmtDNA\u84c4\u7a4d\u306b\u95a2\u9023\u3059\u308b\u554f\u984c\u89e3\u6c7a\u3092\u56f3\u308a\u3001\u672c\u9818\u57df\u306e\u9032\u5c55\u306b\u8ca2\u732e\u3059\u308b\u3053\u3068\u3092\u76ee\u6307\u3059\u3002\u2460\u9818\u57df\u5185\u5916\u3068\u306e\u5171\u540c\u7814\u7a76\u3092\u901a\u3058\u3066\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u54c1\u8cea\u7ba1\u7406\u6d3b\u6027\u306e\u5411\u4e0a\u306b\u3088\u308a\u5909\u7570\u578bmtDNA\u3092\u6709\u3059\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u7a4d\u6975\u7684\u306a\u6392\u9664\u3092\u5b9f\u73fe\u3057\u3001\u5909\u7570\u578bmtDNA\u306e\u84c4\u7a4d\u3092\u6291\u5236\u3059\u308b\u3002\u7279\u306b\u3001\u72ec\u81ea\u306b\u898b\u51fa\u3057\u3066\u304d\u305f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u54c1\u8cea\u7ba1\u7406\u306e\u5236\u5fa1\u7d4c\u8def\uff08\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u56e0\u5b50\u306e\u30ea\u30f3\u9178\u5316\u3001\u5185\u819c\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u306b\u3088\u308b\u5236\u5fa1\u3001\u4f4e\u9178\u7d20\u8a98\u5c0e\u6027\u306e\u5236\u5fa1\uff09\u306b\u7740\u76ee\u3057\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u54c1\u8cea\u7ba1\u7406\u306e\u6d3b\u6027\u5316\u3092\u8a66\u307f\u308b\u3002\u2461\u5909\u7570\u578bmtDNA\u306e\u84c4\u7a4d\u3068\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u54c1\u8cea\u7ba1\u7406\u6d3b\u6027\u306e\u76f8\u4e92\u95a2\u4fc2\u306e\u89e3\u660e\u3092\u901a\u3058\u3066\u3001\u5909\u7570\u578bmtDNA\u304c\u9ad8\u3044\u5272\u5408\u3067\u84c4\u7a4d\u3059\u308b\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u7406\u89e3\u3092\u63a8\u9032\u3059\u308b\u3002\u672c\u8ab2\u984c\u306e\u9042\u884c\u306b\u3088\u308a\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u54c1\u8cea\u7ba1\u7406\u306e\u6d3b\u6027\u5316\u306b\u3088\u308b\u4eba\u70ba\u7684mtDNA\u5236\u5fa1\u3092\u4ecb\u3057\u305f\u753b\u671f\u7684\u306a\u75be\u60a3\u6cbb\u7642\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u63d0\u4f9b\u3059\u308b\u3002<\/p>\n\n\n\n

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                                        \u7814\u7a76\u696d\u7e3e\u3000*\u8cac\u4efb\u8457\u8005<\/span><\/h3>\n\n\n\n
                                          \n
                                        1. Akabane S, Watanabe K, KosakoH, YamashitaS, NishinoK, KatoM, SekineS, KankiT, MatsudaN, EndoT, Oka T*\uff082023) TIM23 facilitates PINK1 activation by safeguarding against OMA1-mediated degradation in damaged mitochondria. Cell Reports<\/em><\/strong>, 42(5):112454<\/li>\n\n\n\n
                                        2. Nakamura S#<\/sup>, Matsui A#<\/sup>, Akabane S#<\/sup>, Tamura Y, Hatano A, Miyano Y, Omote H, Kajikawa M, Maenaka K, Moriyama Y, Endo T, Oka T*(# The authors contributed equally) (2020) The mitochondrial inner membrane protein LETM1 modulates cristae organization through its LETM domain. Communications Biology<\/em>,<\/strong> 3(1):99<\/li>\n\n\n\n
                                        3. Akabane S, Uno M, Tani N, Shimazaki S, Ebara N, Kato H, Kosako H, Oka T* (2016) PKA regulates PINK1 stability and Parkin recruitment to damaged mitochondria through phosphorylation of MIC60. Molecular Cell,<\/em><\/strong> 62(3):371-84<\/li>\n<\/ol>\n<\/div>\n<\/div>\n\n\n\n
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                                          B02-10\uff1a\u30af\u30ed\u30ed\u30d5\u30a1\u30b8\u30fc\u30fb\u30de\u30a4\u30c8\u30d5\u30a1\u30b8\u30fc\u306b\u3088\u308b\u690d\u7269\u7d30\u80de\u8cea\u30b2\u30ce\u30e0\u5236\u5fa1\u6a5f\u69cb\u306e\u89e3\u660e<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/h3>\n\n\n\n
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                                          \u7814\u7a76\u5ba4HP<\/mark>\u3000https:\/\/molecular-bioregulation.riken.jp\/index.html<\/a>
                                          Researchmap<\/mark>\u3000                                          https:\/\/researchmap.jp\/7000010004<\/a>
                                          ORCID<\/mark>\u3000                                          https:\/\/orcid.org\/0000-0001-5222-9163<\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n

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                                          \u8a73\u7d30\u3092\u898b\u308b<\/p>\n<\/span><\/div>\n\n\n\n

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                                          \u52d5\u7269\u30fb\u9175\u6bcd\u306b\u304a\u3044\u3066\u306f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u30b2\u30ce\u30e0\u306e\u7dad\u6301\u30fb\u907a\u4f1d\u306b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\uff08\u30de\u30a4\u30c8\u30d5\u30a1\u30b8\u30fc\uff09\u304c\u6df1\u304f\u95a2\u308f\u308b\u3002\u4e00\u65b9\u3067\u3001\u690d\u7269\u306e\u7d30\u80de\u8cea\u30b2\u30ce\u30e0\uff08\u8449\u7dd1\u4f53\u30b2\u30ce\u30e0\u3068\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u30b2\u30ce\u30e0\uff09\u306e\u7dad\u6301\u30fb\u907a\u4f1d\u306b\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u304c\u3069\u306e\u3088\u3046\u306b\u95a2\u308f\u308b\u304b\u3001\u305d\u306e\u8a73\u7d30\u306f\u4e0d\u660e\u3067\u3042\u308b\u3002\u672c\u7814\u7a76\u3067\u306f\u3001\u9678\u4e0a\u690d\u7269\u306e\u8449\u7dd1\u4f53\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\uff08\u30af\u30ed\u30ed\u30d5\u30a1\u30b8\u30fc\uff09\u3068\u30de\u30a4\u30c8\u30d5\u30a1\u30b8\u30fc\u306e\u7d4c\u8def\u3092\u898b\u51fa\u3057\u3066\u304d\u305f\u4ee3\u8868\u8005\u306e\u7814\u7a76\u3092\u3055\u3089\u306b\u9032\u5c55\u3055\u305b\u3001\u305d\u306e\u8a73\u7d30\u306a\u4ed5\u7d44\u307f\u306e\u89e3\u660e\u3092\u9032\u3081\u308b\u3068\u5171\u306b\u3001\u5f53\u8a72\u9818\u57df\u304c\u767a\u5c55\u3055\u305b\u3066\u3044\u308b\u7d30\u80de\u8cea\u30b2\u30ce\u30e0\u7de8\u96c6\u30fb\u89e3\u6790\u6280\u8853\u3092\u6d3b\u7528\u3059\u308b\u878d\u5408\u7814\u7a76\u3092\u63a8\u9032\u3059\u308b\u3053\u3068\u3067\u3001\u690d\u7269\u7d30\u80de\u8cea\u30b2\u30ce\u30e0\u7dad\u6301\u306b\u304a\u3051\u308b\u30af\u30ed\u30ed\u30d5\u30a1\u30b8\u30fc\u30fb\u30de\u30a4\u30c8\u30d5\u30a1\u30b8\u30fc\u306e\u6a5f\u80fd\u3068\u751f\u7406\u7684\u610f\u7fa9\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3002\u7279\u306b\u3001\u30af\u30ed\u30ed\u30d5\u30a1\u30b8\u30fc\u30fb\u30de\u30a4\u30c8\u30d5\u30a1\u30b8\u30fc\u3092\u5bfe\u8c61\u306b\u3001\u2460\u690d\u7269\u7d30\u80de\u8cea\u30b2\u30ce\u30e0\u5206\u89e3\u3078\u306e\u5bc4\u4e0e\uff08\u8449\u7dd1\u4f53DNA\u30fb\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA\u3092\u5206\u89e3\u3057\u3066\u3044\u308b\u304b\u3001\u8449\u7dd1\u4f53DNA\u30fb\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA\u306e\u2f06\u672c\u9396\u5207\u65ad\u3067\u8a98\u5c0e\u3055\u308c\u308b\u304b\uff09\u3001\u2461\u7d30\u80de\u8cea\u30b2\u30ce\u30e0\u5206\u89e3\u6a5f\u69cb\u3068\u3057\u3066\u306e\u751f\u7406\u7684\u610f\u7fa9\u3001\u306e\u4e8c\u70b9\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u3092\u76ee\u6307\u3059\u3002<\/p>\n\n\n\n

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                                          \u7814\u7a76\u696d\u7e3e\u3000*\u8cac\u4efb\u8457\u8005<\/span><\/h3>\n\n\n\n
                                            \n
                                          1. Izumi M*, Nakamura S, Otomo K, Ishida H, Hidema J, Nemoto T, Hagihara S. (2024) Autophagosome development and chloroplast segmentation occur synchronously for piecemeal degradation of chloroplasts. eLife<\/em><\/strong>, 12: RP93232<\/li>\n\n\n\n
                                          2. Nakamura S, Hagihara S, Otomo K, Ishida H, Hidema J, Nemoto T, Izumi M* (2021) Autophagy contributes to the quality control of leaf mitochondria. Plant Cell Physiol<\/em><\/strong>, 62: 229-247<\/li>\n\n\n\n
                                          3. Kikuchi Y, Nakamura S, Woodson JD, Ishida H, Ling Q, Hidema J, Jarvis RP, Hagihara S, Izumi M* (2020) Chloroplast autophagy and ubiquitination combine to manage oxidative damage and starvation responses. Plant Physiol<\/em><\/strong>, 183: 1531\u20131544<\/li>\n<\/ol>\n<\/div>\n<\/div>\n\n\n\n
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                                            B02-11\uff1a\u30aa\u30eb\u30ac\u30cd\u30e9\u30b2\u30ce\u30e0\u7de8\u96c6\u304c\u66b4\u304f\u30de\u30e9\u30ea\u30a2\u539f\u866b\u306e\u85ac\u5264\u8010\u6027\u6a5f\u69cb<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/h3>\n\n\n\n
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                                            \u7814\u7a76\u5ba4HP<\/mark>\u3000https:\/\/www.juntendo.ac.jp\/graduate\/laboratory\/labo\/kiseityu\/index.html<\/a>
                                            Researchmap<\/mark>\u3000                                            https:\/\/researchmap.jp\/malariamut<\/a>
                                            ORCID<\/mark>\u3000                                            https:\/\/orcid.org\/0000-0002-5001-9653<\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n

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                                            \u8a73\u7d30\u3092\u898b\u308b<\/p>\n<\/span><\/div>\n\n\n\n

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                                            \u30de\u30e9\u30ea\u30a2\u306f\u4e16\u754c\u4e09\u5927\u611f\u67d3\u75c7\u306e\u4e00\u3064\u3067\u3042\u308a\u3001\u7279\u306b\u85ac\u5264\u8010\u6027\u30de\u30e9\u30ea\u30a2\u306f\u30de\u30e9\u30ea\u30a2\u5236\u5727\u306b\u304a\u3051\u308b\u91cd\u5927\u306a\u8ab2\u984c\u3068\u306a\u3063\u3066\u3044\u308b\u3002\u9006\u907a\u4f1d\u5b66\u306b\u3088\u308a\u30de\u30e9\u30ea\u30a2\u306e\u751f\u7269\u5b66\u7684\u7406\u89e3\u304c\u6df1\u307e\u308a\u3001\u305d\u308c\u3092\u5fdc\u7528\u3057\u305f\u85ac\u5264\u958b\u767a\u3082\u9032\u3081\u3089\u308c\u3066\u3044\u308b\u3002\u4e00\u65b9\u3001\u3053\u306e\u624b\u6cd5\u3092\u30aa\u30eb\u30ac\u30cd\u30e9\u306b\u9069\u7528\u3067\u304d\u306a\u3044\u305f\u3081\u3001\u30de\u30e9\u30ea\u30a2\u85ac\u306e\u91cd\u8981\u306a\u6a19\u7684\u3067\u3042\u308b\u30aa\u30eb\u30ac\u30cd\u30e9\u306e\u6a5f\u80fd\u89e3\u6790\u306f\u9032\u3081\u3089\u308c\u3066\u3053\u306a\u304b\u3063\u305f\u3002\u672c\u7814\u7a76\u8ab2\u984c\u3067\u306f\u3001\u30a2\u30d4\u30b3\u30d7\u30e9\u30b9\u30c8\u30b2\u30ce\u30e0\u7de8\u96c6\u6280\u8853\u306e\u958b\u767a\u3092\u76ee\u6307\u3057\u3001\u3053\u308c\u307e\u3067\u672a\u89e3\u660e\u3067\u3042\u3063\u305f\u300c\u30a2\u30d4\u30b3\u30d7\u30e9\u30b9\u30c8\u30b2\u30ce\u30e0\u5909\u7570\u3068\u85ac\u5264\u8010\u6027\u300d\u306e\u95a2\u4fc2\u3092\u89e3\u660e\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3059\u308b\u3002\u5177\u4f53\u7684\u306b\u306f\u3001\u4ee5\u4e0b\u306e3\u3064\u306e\u30b9\u30c6\u30c3\u30d7\u3092\u5b9f\u65bd\u3059\u308b\u3002\u2460 apicoTALENs\u306e\u958b\u767a: \u690d\u7269\u3067\u78ba\u7acb\u3055\u308c\u305fmitoTALENs\u3092\u53c2\u8003\u306b\u3001\u540c\u5b9a\u6e08\u306e\u30a2\u30d4\u30b3\u30d7\u30e9\u30b9\u30c8\u5c40\u5728\u30b7\u30b0\u30ca\u30eb\u30da\u30d7\u30c1\u30c9\u3092\u5229\u7528\u3057\u3066apicoTALENs\u3092\u958b\u767a\u3059\u308b\uff08\u6709\u6751\u30b0\u30eb\u30fc\u30d7\u3068\u306e\u5171\u540c\u7814\u7a76\uff09\u3002\u2461 \u30a2\u30d4\u30b3\u30d7\u30e9\u30b9\u30c8\u7a81\u7136\u5909\u7570\u4f53\u30e9\u30a4\u30d6\u30e9\u30ea\u30fc\u306e\u4f5c\u6210\u3068\u85ac\u5264\u8010\u6027\u539f\u866b\u306e\u5358\u96e2: \u30a2\u30d4\u30b3\u30d7\u30e9\u30b9\u30c8\u7a81\u7136\u5909\u7570\u4f53\u30de\u30e9\u30ea\u30a2\u539f\u866b\u306e\u30e9\u30a4\u30d6\u30e9\u30ea\u30fc\u3092\u4f5c\u6210\u3057\u3001\u305d\u306e\u4e2d\u304b\u3089\u30a2\u30d4\u30b3\u30d7\u30e9\u30b9\u30c8\u30b2\u30ce\u30e0\u5909\u7570\u306b\u8d77\u56e0\u3059\u308b\u85ac\u5264\u8010\u6027\u539f\u866b\u3092\u5358\u96e2\u3059\u308b\u3002\u8010\u6027\u306b\u95a2\u4e0e\u3059\u308b\u5019\u88dc\u907a\u4f1d\u5b50\u5909\u7570\u3092\u62bd\u51fa\u3059\u308b\u3002\u2462 \u5019\u88dc\u907a\u4f1d\u5b50\u5909\u7570\u3068\u8010\u6027\u3068\u306e\u95a2\u4fc2\u3092\u691c\u8a3c: apicoTALENs\u306b\u3088\u308b\u7de8\u96c6\u304c\u53ef\u80fd\u306a\u5019\u88dc\u907a\u4f1d\u5b50\u5909\u7570\u3092\u85ac\u5264\u611f\u53d7\u6027\u91ce\u751f\u578b\u539f\u866b\u306b\u5c0e\u5165\u3057\u3001\u85ac\u5264\u8010\u6027\u3078\u306e\u95a2\u4e0e\u3092\u691c\u8a3c\u3059\u308b\u3002<\/p>\n\n\n\n

                                            \"\"<\/figure>\n\n\n\n

                                            \u7814\u7a76\u696d\u7e3e\u3000*\u8cac\u4efb\u8457\u8005<\/span><\/h3>\n\n\n\n
                                              \n
                                            1. Hirai M*, Arai M, Hayamichi S, Uchida A, Sudo M, Kubota R, Shinzawa N, Mita T (2025) Deletion of the chloroquine resistance transporter<\/em> gene confers reduced piperaquine susceptibility to the rodent malaria parasite Plasmodium bergheim<\/em>. Antimicrob Agents Chemother<\/em><\/strong>. e0158924.<\/li>\n\n\n\n
                                            2. Ikeda M#, Hirai M#*, Tachibana SI, Mori T, Mita T. (2021) Isolation of mutants with reduced susceptibility to piperaquine from a mutator of the rodent malaria parasite Plasmodium berghei<\/em>. Front Cell Infect Microbiol.<\/em><\/strong> 11:672691. #Equal contribution<\/li>\n\n\n\n
                                            3. Honma H, Niikura M, Kobayashi F, Horii T, Mita T, Endo H, Hirai M* (2016) Mutation tendency of mutator Plasmodium berghei<\/em> with proofreading-deficient DNA polymerase \u03b4. Sci Rep<\/em><\/strong>. 6:3697<\/li>\n<\/ol>\n<\/div>\n<\/div>\n\n\n\n
                                              <\/div>\n\n\n\n

                                              B02-12\uff1a\u52d5\u690d\u7269\u7d30\u80de\u5185\u306b\u5bc4\u751f\u3059\u308b\u96e3\u57f9\u990a\u6027\u7d30\u83cc\u306e\u30b2\u30ce\u30e0\u5236\u5fa1\u7cfb\u306e\u78ba\u7acb<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/h3>\n\n\n\n
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                                              \"\"<\/figure>\n<\/div>\n\n\n\n
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                                              \u524d\u5cf6 \u5065\u4f5c<\/h4>\n\n\n\n

                                              \u7814\u7a76\u4ee3\u8868\u8005
                                              \u6771\u4eac\u5927\u5b66\u30fb\u5927\u5b66\u9662\u8fb2\u5b66\u751f\u547d\u79d1\u5b66\u7814\u7a76\u79d1\uff08\u8fb2\u5b66\u90e8\uff09\u3000\u51c6\u6559\u6388
                                              \u7814\u7a76\u5ba4HP<\/mark>\u3000https:\/\/webpark1802.sakura.ne.jp\/planpath\/<\/a>
                                              Researchmap<\/mark>\u3000                                              https:\/\/researchmap.jp\/k-maejima<\/a>
                                              ORCID<\/mark>\u3000                                              https:\/\/orcid.org\/0000-0003-1960-6232<\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n

                                              <\/div><\/div>\n\n\n\n
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                                              \u8a73\u7d30\u3092\u898b\u308b<\/p>\n<\/span><\/div>\n\n\n\n

                                              \n

                                              \u52d5\u690d\u7269\u306e\u7d30\u80de\u5185\u306b\u7d76\u5bfe\u5bc4\u751f\u3059\u308b\u7d30\u83cc\u306f\u5358\u72ec\u57f9\u990a\u6280\u8853\u304c\u672a\u78ba\u7acb\u3067\u3042\u308b\u305f\u3081\u7814\u7a76\u304c\u56f0\u96e3\u3067\u3042\u308a\u3001\u3068\u308a\u308f\u3051\u5f62\u8cea\u8ee2\u63db\u7cfb\u3092\u5229\u7528\u3067\u304d\u306a\u3044\u70b9\u304c\u5927\u304d\u306a\u969c\u58c1\u3068\u306a\u3063\u3066\u3044\u308b\u3002\u690d\u7269\u75c5\u539f\u7d30\u83cc\u30d5\u30a1\u30a4\u30c8\u30d7\u30e9\u30ba\u30de\u306f\u305d\u306e\u4ee3\u8868\u4f8b\u3060\u304c\u3001\u8fd1\u5e74\u3001\u6211\u3005\u306e\u7814\u7a76\u306b\u3088\u308a\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u306a\u8ee2\u5199\u5236\u5fa1\u7cfb\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u3001\u307e\u305f\u5897\u6b96\u3092\u6291\u5236\u3059\u308b\u6297\u751f\u7269\u8cea\u3068\u305d\u306e\u51e6\u7406\u6280\u8853\u304c\u78ba\u7acb\u3055\u308c\u3066\u3044\u308b\u3002\u672c\u7814\u7a76\u3067\u306f\u3001\u3053\u308c\u3089\u306e\u77e5\u898b\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u52b9\u7387\u7684\u306a\u907a\u4f1d\u5b50\u767a\u73fe\u7cfb\u3084\u85ac\u5264\u9078\u629c\u7cfb\u3092\u958b\u767a\u3059\u308b\u3068\u3068\u3082\u306b\u3001\u611f\u67d3\u5bbf\u4e3b\u304b\u3089\u30a4\u30f3\u30bf\u30af\u30c8\u306a\uff08\u6d3b\u6027\u306e\u3042\u308b\uff09\u72b6\u614b\u3067\u30d5\u30a1\u30a4\u30c8\u30d7\u30e9\u30ba\u30de\u3092\u53d6\u308a\u51fa\u3057\u3001\u300c\u57f9\u990a\u3092\u7d4c\u305a\u306bDNA\u3092\u5c0e\u5165\u3059\u308b\u30b2\u30ce\u30e0\u5236\u5fa1\u6280\u8853\u300d\u306e\u958b\u767a\u306b\u6311\u6226\u3059\u308b\u3002DNA\u306e\u5c0e\u5165\u30fb\u767a\u73fe\u3055\u3089\u306b\u306f\u907a\u4f1d\u5b50\u7834\u58ca\u30fb\u7de8\u96c6\u306e\u624b\u6cd5\u3092\u69cb\u7bc9\u3059\u308b\u3053\u3068\u3067\u3001\u3053\u308c\u307e\u3067\u3068\u308a\u308f\u3051\u56f0\u96e3\u3067\u3042\u3063\u305f\u7d76\u5bfe\u5bc4\u751f\u7d30\u83cc\u306e\u3055\u307e\u3056\u307e\u306a\u6027\u72b6\u3092\u89e3\u660e\u3057\u3001\u3055\u3089\u306b\u306f\u9632\u9664\u30fb\u4e88\u9632\u3078\u5411\u3051\u305f\u7814\u7a76\u3078\u306e\u91cd\u3044\u6249\u3092\u958b\u304f\u3068\u3068\u3082\u306b\u3001\u4ed6\u306e\u7d30\u80de\u5185\u5bc4\u751f\u30fb\u5171\u751f\u7d30\u83cc\u3078\u306e\u5fdc\u7528\u306a\u3069\u3001\u5e45\u5e83\u3044\u5b66\u554f\u5206\u91ce\u3078\u306e\u6ce2\u53ca\u52b9\u679c\u3092\u3082\u305f\u3089\u3057\u305f\u3044\u3002<\/p>\n\n\n\n

                                              \"\"<\/figure>\n\n\n\n

                                              \u7814\u7a76\u696d\u7e3e\u3000*\u8cac\u4efb\u8457\u8005<\/span><\/h3>\n\n\n\n
                                                \n
                                              1. Akahori M, Miyazaki A, Koinuma H, Tokuda R, Iwabuchi N, Kitazawa Y, Maejima K*, Namba S, Yamaji Y (2024) Use of the 23S rRNA gene as a target template in the universal loop-mediated isothermal amplification (LAMP) of genomic DNA from phytoplasmas. Microbiol Spectr<\/em><\/strong>, 27: e0010624.<\/li>\n\n\n\n
                                              2. Suzuki M, Kitazawa Y, Iwabuchi N, Maejima K*, Matsuyama J, Matsumoto O, Oshima K, Namba S, Yamaji Y (2024) Target degradation specificity of phytoplasma effector phyllogen is regulated by the recruitment of host proteasome shuttle protein. Mol Plant Pathol<\/em><\/strong>, 25: e13410.<\/li>\n\n\n\n
                                              3. Kitazawa Y, Iwabuchi N, Maejima K*, Sasano M, Matsumoto O, Koinuma H, Tokuda R, Suzuki M, Oshima K, Namba S, Yamaji Y (2022) A phytoplasma effector acts as a ubiquitin-like mediator between floral MADS-box proteins and proteasome shuttle proteins. Plant Cell<\/em><\/strong>, 34: 1709\u20131723.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n\n\n\n
                                                <\/div>\n\n\n\n

                                                B02-13\uff1a\u30de\u30e9\u30ea\u30a2\u539f\u866b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u30b2\u30ce\u30e0\u7de8\u96c6\u306b\u3088\u308b\u547c\u5438\u9396\u963b\u5bb3\u5264\u8010\u6027\u6a5f\u69cb\u306e\u89e3\u660e<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/h3>\n\n\n\n
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                                                \u4f50\u5009 \u5b5d\u54c9<\/h4>\n\n\n\n

                                                \u7814\u7a76\u4ee3\u8868\u8005
                                                \u9577\u5d0e\u5927\u5b66\u30fb\u71b1\u5e2f\u533b\u5b66\u7814\u7a76\u6240\u3000\u51c6\u6559\u6388
                                                \u7814\u7a76\u5ba4HP<\/mark>\u3000https:\/\/www.tm.nagasaki-u.ac.jp\/molecdyna\/<\/a>
                                                Researchmap<\/mark>\u3000                                                https:\/\/researchmap.jp\/-2qE3_xt<\/a>
                                                ORCID<\/mark>\u3000                                                https:\/\/orcid.org\/0000-0002-8320-8485<\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n

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                                                \u8a73\u7d30\u3092\u898b\u308b<\/p>\n<\/span><\/div>\n\n\n\n

                                                \n

                                                \u30de\u30e9\u30ea\u30a2\u539f\u866b\u306f\u868a\u3001\u30d2\u30c8\u809d\u7d30\u80de\u3001\u30d2\u30c8\u8d64\u8840\u7403\u30683\u3064\u306e\u767a\u80b2\u30b9\u30c6\u30fc\u30b8\u3092\u6301\u3064\u304c\u3001cytochrome bc<\/em>1<\/sub> complex\u306e\u963b\u5bb3\u5264\u306f\u3053\u308c\u3089\u5168\u3066\u306e\u30b9\u30c6\u30fc\u30b8\u306b\u52b9\u679c\u304c\u3042\u308b\u305f\u3081\u3001\u30de\u30e9\u30ea\u30a2\u539f\u866b\u306e\u547c\u5438\u9396\u306f\u9b45\u529b\u7684\u306a\u5275\u85ac\u6a19\u7684\u3067\u3042\u308b\u3002\u65e2\u5b58\u306e\u30de\u30e9\u30ea\u30a2\u6cbb\u7642\u85ac\u3067\u3042\u308b\u30a2\u30c8\u30d0\u30b3\u30f3\u306fcytochrome bc<\/em>1<\/sub> complex\u3092\u963b\u5bb3\u3059\u308b\u304c\u3001\u6d41\u884c\u5730\u306b\u304a\u3044\u3066cytochrome b<\/em>\u306b\u70b9\u5909\u7570\u3092\u6301\u3064\u85ac\u5264\u8010\u6027\u30de\u30e9\u30ea\u30a2\u539f\u866b\u304c\u51fa\u73fe\u3057\u3066\u3044\u308b\u3002\u3057\u304b\u3057cytochrome b<\/em>\u304c\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u30b2\u30ce\u30e0\u306b\u30b3\u30fc\u30c9\u3055\u308c\u3066\u3044\u308b\u305f\u3081\u3001\u30b2\u30ce\u30e0\u7de8\u96c6\u306b\u3088\u308b\u9006\u907a\u4f1d\u5b66\u7684\u624b\u6cd5\u306b\u3088\u308b\u70b9\u5909\u7570\u5c0e\u5165\u304c\u3067\u304d\u305a\u3001\u547c\u5438\u9396\u6a5f\u80fd\u3078\u306e\u5f71\u97ff\u3084\u85ac\u5264\u8010\u6027\u6a5f\u69cb\u306e\u7406\u89e3\u306f\u672a\u3060\u306b\u9650\u5b9a\u7684\u3067\u3042\u308b\u3002\u672c\u7814\u7a76\u306e\u76ee\u7684\u306f\u2460\u30de\u30e9\u30ea\u30a2\u539f\u866b\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u30b2\u30ce\u30e0\u7de8\u96c6\u6280\u8853\u3092\u78ba\u7acb\u3057\u3001\u2461\u5909\u7570\u4f53\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u6a5f\u80fd\u3092\u5b9a\u91cf\u7684\u306b\u8a55\u4fa1\u3059\u308b\u3053\u3068\u3067\u3042\u308b\u3002\u672c\u7814\u7a76\u306b\u3088\u308a\u30b0\u30ed\u30fc\u30d0\u30eb\u30d8\u30eb\u30b9\u306e\u6700\u91cd\u8981\u8ab2\u984c\u306e\u4e00\u3064\u3067\u3042\u308b\u30de\u30e9\u30ea\u30a2\u5236\u5fa1\u306b\u591a\u5927\u306a\u8ca2\u732e\u304c\u3067\u304d\u308b\u3068\u8003\u3048\u3066\u3044\u308b\u3002<\/p>\n\n\n\n

                                                \"\"<\/figure>\n\n\n\n

                                                \u7814\u7a76\u696d\u7e3e\u3000*\u8cac\u4efb\u8457\u8005<\/span><\/h3>\n\n\n\n
                                                  \n
                                                1. Sakura T, Ishii R, Yoshida E, Kita K, Kato T, Inaoka DK* (2024). Accelerating Antimalarial Drug Discovery with a New High-Throughput Screen for Fast-Killing Compounds. ACS Infect Dis<\/em><\/strong>. 10(12):4115-4126.<\/li>\n\n\n\n
                                                2. Komatsuya K, Sakura T (Co-first), Shiomi K, \u014cmura S, Hikosaka K, Nozaki T, Kita K, Inaoka DK* (2022). Siccanin Is a Dual-Target Inhibitor of Plasmodium falciparum<\/em> Mitochondrial Complex II and Complex III. Pharmaceuticals (Basel)<\/em><\/strong>. 15(7):903.<\/li>\n\n\n\n
                                                3. Sakura T, Sindikubwabo F, Oesterlin LK, Bousquet H, Slomianny C, Hakimi MA, Langsley G, Tomavo S* (2016). A Critical Role for Toxoplasma gondii <\/em>Vacuolar Protein Sorting VPS9 in Secretory Organelle Biogenesis and Host Infection. Sci Rep<\/em><\/strong>. 6:38842.<\/li>\n<\/ol>\n<\/div>\n<\/div>\n\n\n\n
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                                                  \u82e5\u624b\u306e\u4f1a\u904b\u55b6\u59d4\u54e1<\/h2>\n\n\n\n

                                                  \u963f\u90e8 \u76f4\u54c9 \uff08\u4eac\u90fd\u5927\u5b66\u5927\u5b66\u9662\u5de5\u5b66\u7814\u7a76\u79d1\u30fbA01 \u6cbc\u7530\u73ed\uff09
                                                  \u5c0f\u7b20\u539f \u7d75\u7f8e\uff08\u5927\u962a\u5927\u5b66\u5927\u5b66\u9662\u7406\u5b66\u7814\u7a76\u79d1\u30fbB02 \u77f3\u539f\u73ed\uff09
                                                  \u52dd\u6ff5 \u76f4\u6930\uff08\u6771\u4eac\u5927\u5b66\u5927\u5b66\u9662\u8fb2\u5b66\u751f\u547d\u79d1\u5b66\u7814\u7a76\u79d1\u30fbB02 \u77e2\u5b88\u73ed\uff09
                                                  \u91d1\u6fa4 \u6674\u6a39\uff08\u4eac\u90fd\u5927\u5b66\u5927\u5b66\u9662\u7406\u5b66\u7814\u7a76\u79d1\u30fbB01 \u897f\u6751\u73ed\uff09
                                                  \u4e2d\u91cc \u4e00\u661f\uff08\u6771\u4eac\u5927\u5b66\u5927\u5b66\u9662\u8fb2\u5b66\u751f\u547d\u79d1\u5b66\u7814\u7a76\u79d1\u30fbA01 \u6709\u6751\u73ed\uff09
                                                  \u6cd5\u6708 \u62d3\u4e5f\uff08\u7fa4\u99ac\u5927\u5b66\u751f\u4f53\u8abf\u7bc0\u7814\u7a76\u6240\u30fbB01 \u4f50\u85e4\u73ed\uff09
                                                  \u9ec4 \u6042\u6021\uff08\u6771\u4eac\u5927\u5b66\u5927\u5b66\u9662\u8fb2\u5b66\u751f\u547d\u79d1\u5b66\u7814\u7a76\u79d1\u30fbA01 \u6709\u6751\u73ed\uff09
                                                  \u5c0f\u5742 \u4e03\u6d77\uff08\u6771\u4eac\u5927\u5b66\u5927\u5b66\u9662\u8fb2\u5b66\u751f\u547d\u79d1\u5b66\u7814\u7a76\u79d1\u30fbA01 \u6709\u6751\u73ed\uff09
                                                  \u4f50\u3005\u6728 \u5999\u5b50\uff08\u7fa4\u99ac\u5927\u5b66\u751f\u4f53\u8abf\u7bc0\u7814\u7a76\u6240\u30fbB01\u4f50\u85e4\u73ed\uff09
                                                  \u9ad9\u585a \u6b69\uff08\u4e5d\u5dde\u5927\u5b66\u5927\u5b66\u9662\u8fb2\u5b66\u7814\u7a76\u9662\u30fbB02 \u98a8\u9593\u73ed\uff09
                                                  \u4e2d\u5d8b \u68a8\u82b1\uff08\u6771\u4eac\u5927\u5b66\u5927\u5b66\u9662\u8fb2\u5b66\u751f\u547d\u79d1\u5b66\u7814\u7a76\u79d1\u30fbA01 \u6709\u6751\u73ed\uff09
                                                  \u9593\u5bae \u7ae0\u4ec1\uff08\u4eac\u90fd\u5927\u5b66\u5927\u5b66\u9662\u7406\u5b66\u7814\u7a76\u79d1\u30fbB01\u7af9\u4e2d\u73ed\uff09
                                                  \u6a4b\u672c \u5c06\uff08\u6771\u4eac\u5927\u5b66\u5927\u5b66\u9662\u8fb2\u5b66\u751f\u547d\u79d1\u5b66\u7814\u7a76\u79d1\u30fbA01 \u6709\u6751\u73ed\uff09
                                                  \u5bae\u5ddd \u6587\u5b8f\uff08\u5ca1\u5c71\u5927\u5b66\u5b66\u8853\u7814\u7a76\u9662 \u74b0\u5883\u751f\u547d\u81ea\u7136\u79d1\u5b66\u5b66\u57df\uff09
                                                  \u5f35\u5586 (Ellen)\uff08\u6771\u4eac\u5927\u5b66\u5927\u5b66\u9662\u8fb2\u5b66\u751f\u547d\u79d1\u5b66\u7814\u7a76\u79d1\u30fbB02 \u77e2\u5b88\u73ed\uff09<\/p>\n\n\n\n

                                                  \n
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                                                  \u963f\u90e8 \u76f4\u54c9<\/figcaption><\/figure>\n<\/div>\n\n\n\n
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                                                  \"\"
                                                  \u5c0f\u7b20\u539f \u7d75\u7f8e<\/figcaption><\/figure>\n<\/div>\n\n\n\n
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                                                  \"\"
                                                  \u52dd\u6ff5 \u76f4\u6930<\/figcaption><\/figure>\n<\/div>\n\n\n\n
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                                                  \u91d1\u6fa4 \u6674\u6a39<\/figcaption><\/figure>\n<\/div>\n\n\n\n
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                                                  \"\"
                                                  \u4e2d\u91cc \u4e00\u661f<\/figcaption><\/figure>\n<\/div>\n\n\n\n
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                                                  \"\"
                                                  \u6cd5\u6708 \u62d3\u4e5f<\/figcaption><\/figure>\n<\/div>\n\n\n\n
                                                  \n
                                                  \"\"
                                                  \u9ec4 \u6042\u6021<\/figcaption><\/figure>\n<\/div>\n<\/div>\n\n\n\n
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                                                  \"\"
                                                  \u5c0f\u5742 \u4e03\u6d77<\/figcaption><\/figure>\n\n\n\n
                                                  \"\"
                                                  \u5f35\u5586 (Ellen)<\/figcaption><\/figure>\n<\/div>\n\n\n\n
                                                  \n
                                                  \"\"
                                                  \u4f50\u3005\u6728 \u5999\u5b50<\/figcaption><\/figure>\n<\/div>\n\n\n\n
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                                                  \"\"
                                                  \u9ad9\u585a \u6b69<\/figcaption><\/figure>\n<\/div>\n\n\n\n
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                                                  \u4e2d\u5d8b \u68a8\u82b1<\/figcaption><\/figure>\n<\/div>\n\n\n\n
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                                                  \u9593\u5bae \u7ae0\u4ec1<\/figcaption><\/figure>\n<\/div>\n\n\n\n
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                                                  \"\"
                                                  \u6a4b\u672c \u5c06<\/figcaption><\/figure>\n<\/div>\n\n\n\n
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                                                  \"\"
                                                  \u5bae\u5ddd \u6587\u5b8f<\/figcaption><\/figure>\n<\/div>\n<\/div>\n\n\n\n

                                                  \u7814\u7a76\u652f\u63f4<\/strong><\/h2>\n\n\n\n

                                                  <\/p>\n\n\n\n