{"id":110,"date":"2024-04-25T18:04:26","date_gmt":"2024-04-25T09:04:26","guid":{"rendered":"https:\/\/www.agr.kyushu-u.ac.jp\/lab\/csii\/wordpress\/?page_id=110"},"modified":"2026-09-25T09:22:52","modified_gmt":"2026-09-25T00:22:52","slug":"publication","status":"publish","type":"page","link":"https:\/\/www.agr.kyushu-u.ac.jp\/lab\/csii\/wordpress\/publication\/","title":{"rendered":"Publications"},"content":{"rendered":"\n

Publications<\/h2>\n\n\n\n

2026<\/h2>\n\n\n\n

Tomoki Sasaki, Akitsu Masuda, Jae Man Lee, Shigeyuki Tamiya, Yusaku Mikaki, Kiyotada Naitou, Masahiro Taniguchi, Ako Kimura, Yuuka Chieda, Hiroshi Ushijima, Naomi Sakon, Shintaro Sato, Takeru Ebihara, Hiroaki Mon, Takahiro Kusakabe, Takeshi Miyata
Immunogenicity of norovirus VP1-expressing silkworm (Bombyx mori) pupae as an edible vaccine candidate
<\/a><\/strong>Vaccine, 2026,\u00a092:129108.<\/p>\n\n\n\n

Nura Abubakar, Jae Man Lee, Akitsu Masuda, Toshiaki Fujimoto, Hiroaki Mon, Tsuguru Fujii, Masateru Takahashi, Takahiro Kusakabe, Masato Hino
Highly proliferative silkworm cell line: Development of a new line for recombinant protein production<\/a><\/strong>
Protein Expression and Purification, 2026, 242:106951.<\/p>\n\n\n\n

Jumpei Tagawa, Saeko Yanaka, Yuri Kato, Akitsu Masuda, Jae Man Lee, Akinobu Senoo, Kosuke Oyama, Takayuki Uchihashi, Motohiro Nishida, Takahiro Kusakabe, Jose M. M. Caaveiro
Characterization of high affinity IgM and IgG monoclonal antibodies against norovirus variants GII.4 and GII.17<\/a><\/strong>
Protein Science, 2026, 35:4:e70522.<\/p>\n\n\n\n

Sara Murata, Soichiro Sonoda, Yukari Kyumoto-Nakamura, M. Majd Sharifa, Liting Yu, Reona Aijima, Erika Yamauchi-Tomoda, Fouad MHD. Zakaria, Hiroki Kato, Norihisa Uehara, Haruyoshi Yamaza, Takayoshi Yamaza
Deciduous pulp stem cell-derived extracellular vesicles stimulate the proliferation of cartilage progenitor cells via extracellular signal-regulated protein kinase 1\/2 activation<\/a><\/strong>
Scientific Reports, 2026, 16:12654.<\/p>\n\n\n\n

Soichiro Sonoda, Liting Yu, Lisha Dai, Yukari Kyumoto-Nakamura, Koichiro Yoshimaru, Ratih Yuniartha, Ying Liu, M. Majd Sharifa, Sara Murata, Mohammed Fouad Zakaria, Hiroki Kato, Norihisa Uehara, Satoshi Fukumoto, Haruyoshi Yamaza, Toshiharu Matsuura, Tomoaki Taguchi, Tatsuro Tajiri, Takayoshi Yamaza
Dental pulp stem cells maintain epigenetic chromatin architecture remodeling primed by the etiological stimulus of biliary atresia<\/a><\/strong>
Stem Cell Research & Therapy, 2026, 17:136.<\/p>\n\n\n\n

2025<\/h2>\n\n\n\n

Yuto Tsurumi, Akitsu Masuda, Jian Xu, Hiroaki Mon, Takahiro Kusakabe, Jae Man Lee
Structural and stability differences among GI norovirus virus-like particles produced in silkworm-baculovirus expression vector system<\/a><\/strong>
Frontiers in microbiology, 2025, 16:1739683-1739683.<\/p>\n\n\n\n

2024<\/h2>\n\n\n\n

Yuto Tsurumi, Keisuke Morimoto, Akitsu Masuda, Jae Man Lee, Hiroaki Mon, Takahiro Kusakabe
<\/a>Production of Norovirus VLPs of the Nine Representative Genotypes Widely Distributed in Japan using the Silkworm-Baculovirus Expression Vector System<\/a><\/strong>
Journal of Virological Methods, 2024, 331:115038.<\/p>\n\n\n\n

Yara Atef, Tomoya Ito, Akitsu Masuda, Yuri Kato, Akiyuki Nishimura, Yasunari Kanda, Jun Kunisawa, Takahiro Kusakabe, Motohiro Nishida
Diabetic Mice Spleen Vulnerability Contributes to Decreased Persistence of Antibody Production after SARS-CoV-2 Vaccine<\/strong>
<\/a>International journal of molecular sciences, 2024, 25:19:10379.<\/p>\n\n\n\n

Akira Tsukamoto, Lee Jae Man, Kosuke Oyama, Akitsu Masuda, Hiroaki Mon, Tadashi Ueda, Takahiro Kusakabe
Effective expression and characterization of the receptor binding domains in SARS-CoV-2 Spike proteins from original strain and variants of concern using Bombyx mori nucleopolyhedrovirus in silkworm<\/a><\/strong>
Protein Expression and Purification, 2024, 218:106450.<\/p>\n\n\n\n

Jumpei Tagawa, Saeko Yanaka, Yuri Kato, Akitsu Masuda, Jae Man Lee, Akinobu Senoo, Kosuke Oyama, Motohiro Nishida, Takahiro Kusakabe, Jose M.M. Caaveiro
<\/a>Characterization of high affinity IgM and IgG monoclonal antibodies against norovirus variants GII.4 and GII.17<\/a><\/strong>
bioRxiv, 2024.<\/p>\n\n\n\n

2023<\/h2>\n\n\n\n

Kohei Kakino, Hiroaki Mon, Takeru Ebihara, Masato Hino, Akitsu Masuda, Jae Man Lee, Takahiro Kusakabe
Comprehensive Transcriptome Analysis in the Testis of the Silkworm, Bombyx mori<\/a><\/strong>
Insects, 2023, 14:8:684.<\/p>\n\n\n\n

Takeyuki Goto, Tomoki Sasaki, Yong Chong, Masahiro Taniguchi, Jae Man Lee, Akitsu Masuda, Takeru Ebihara, Kenichiro Shiraishi, Naoki Tani, Akiko Yonekawa, Kei Gondo, Hiroyuki Kuwano, Nobuyuki Shimono, Hideyuki Ikematsu, Koichi Akashi, Takahiro Kusakabe
SARS-CoV-2 strain-specific anti-Spike IgG ELISA utilizing spike protein produced by silkworms<\/a><\/strong>
Human Antibodies, 2023, 31:3:27-33.<\/p>\n\n\n\n

Akihiro Morio, Jae Man Lee, Tsuguru Fujii, Hiroaki Mon, Akitsu Masuda, Kohei Kakino, Jian Xu, Yutaka Banno, Takahiro Kusakabe
The biological role of core 1\u03b21-3galactosyltransferase (T-synthase) in mucin-type O-<\/em>glycosylation in Silkworm, Bombyx mori<\/em><\/a><\/strong>
Insect Biochemistry and Molecular Biology, 2023, 156:103936.<\/p>\n\n\n\n

Keisuke Tanaka, Kosuke Minamihata, Rie Wakabayashi, Jae Man Lee, Takeshi Miyata, Takahiro Kusakabe, Noriho Kamiya, Masahiro Goto
Transdermal Transmission Blocking Vaccine for Malaria using a Solid-in-Oil Dispersion<\/a><\/strong>
Journal of Pharmaceutical Sciences, 2023, 112:2:411-415.<\/p>\n\n\n\n

Akitsu Masuda, Jae Man Lee, Takeshi Miyata, Shintaro Sato, Atsushi Masuda, Masahiro Taniguchi, Ryosuke Fujita, Hiroshi Ushijima, Keisuke Morimoto, Takeru Ebihara, Masato Hino, Kohei Kakino, Hiroaki Mon, Takahiro Kusakabe
High yield production of norovirus GII.4 virus-like particles using silkworm pupae and evaluation of their protective immunogenicity<\/strong><\/a>
Vaccine, 2023, 41:3:766-777.<\/p>\n\n\n\n

Yuri Kato, Kazuhiro Nishiyama, Jae Man Lee, Yuko Ibuki, Yumiko Imai, Takamasa Noda, Noriho Kamiya, Takahiro Kusakabe, Yasunari Kanda, Motohiro Nishida
TRPC3-Nox2 Protein Complex Formation Increases the Risk of SARS-CoV-2 Spike Protein-Induced Cardiomyocyte Dysfunction through ACE2 Upregulation<\/a><\/strong>
International Journal of Molecular Sciences, 2023, 24:1:102.<\/p>\n\n\n\n

2022<\/h2>\n\n\n\n

Takeshi Miyata, Kosuke Minamihata, Koichi Kurihara, Yui Kamizuru, Mari Gotanda, Momoka Obayashi, Taiki Kitagawa, Keita Sato, Momoko Kimura, Kosuke Oyama, Yuta Ikeda, Yukihiro Tamaki, Jae Man Lee, Kozue Sakao, Daisuke Hamanaka, Takahiro Kusakabe, Mayumi Tachibana, Hisham R Ibrahim
Highly efficient protein expression of Plasmodium vivax surface antigen, Pvs25, by silkworm and its biochemical analysis<\/strong><\/a>
Protein Expression and Purification, 2022, 195-196:106096.<\/p>\n\n\n\n

Masato Hino, Tsuneyuki Tatsuke, Akihiro Morio, Hiroaki Mon, Jae Man Lee, Akitsu Masuda, Kohei Kakino, Yoshino Tonooka, Takahiro Kusakabe
Characterization of a Novel Heterochromatin Protein 1 Homolog \u201cHP1c\u201d in the Silkworm, Bombyx mori<\/strong><\/a>
Insects, 2022, 13:7:631.<\/p>\n\n\n\n

Miyu Tanaka, Tsuguru Fujii, Hiroaki Mon, Jae Man Lee, Kohei Kakino, Hisayoshi Fukumori, Takeru Ebihara, Takumi Nagasato, Masato Hino, Yoshino Tonooka, Takato Moriyama, Ryosuke Fujita, Yutaka Banno, Takahiro Kusakabe
Silkworm FoxL21 plays important roles as a regulator of ovarian development in both oogenesis and ovariole development<\/a><\/strong>
Insect biochemistry and molecular biology, 2022, 143:103737.<\/p>\n\n\n\n

Akitsu Masuda, Jae Man Lee, Takeshi Miyata, Hiroaki Mon, Keita Sato, Kosuke Oyama, Yasuteru Sakurai, Jiro Yasuda, Daisuke Takahashi, Tadashi Ueda, Yuri Kato, Motohiro Nishida, Noriko Karasaki, Kohei Kakino, Takeru Ebihara, Takumi Nagasato, Masato Hino, Ayaka Nakashima, Kengo Suzuki, Yoshino Tonooka, Miyu Tanaka, Takato Moriyama, Hirokazu Nakatake, Ryosuke Fujita, Takahiro Kusakabe
Optimization of SARS-CoV-2 Spike Protein Expression in the Silkworm and Induction of Efficient Protective Immunity by Inoculation With Alum Adjuvants<\/strong><\/a>
Frontiers in Immunology, 2022, 12:803647.<\/p>\n\n\n\n

2021<\/h2>\n\n\n\n

Hirofumi Ohga, Kosuke Ito, Kohei Kakino, Hiroaki Mon, Takahiro Kusakabe, Jae Man Lee, Michiya Matsuyama
Leptin Is an Important Endocrine Player That Directly Activates Gonadotropic Cells in Teleost Fish, Chub Mackerel<\/a><\/strong>
CELLS, 2021, 10:12:3505.<\/p>\n\n\n\n

Tsuguru Fujii, Kohei Kakino, Hisayoshi Fukumori, Masato Hino, JaeMan Lee, Takahiro Kusakabe, Yutaka Banno
Non-molting dwarf (nm-d<\/em>) as a mutant of Bombyx mori<\/em> with a defect in purine synthesis<\/a><\/strong>
Insect Biochemistry and Molecular Biology, 2021, 138:103636.<\/p>\n\n\n\n

Takeru Ebihara, Akitsu Masuda, Daisuke Takahashi, Masato Hino, Hiroaki Mon, Kohei Kakino, Tsuguru Fujii, Ryosuke Fujita, Tadashi Ueda, Jae Man Lee, Takahiro Kusakabe
Production of scFv, Fab, and IgG of CR3022 Antibodies Against SARS-CoV-2 Using Silkworm-Baculovirus Expression System<\/a><\/strong>
Molecular Biotechnology, 2021, 63:12:1223-1234.<\/p>\n\n\n\n

Akitsu Masuda, Jae Man Lee, Takeshi Miyata, Takeru Ebihara, Kohei Kakino, Masato Hino, Ryosuke Fujita, Hiroaki Mon, Takahiro Kusakabe
Stable trimer formation of spike protein from porcine epidemic diarrhea virus improves the efficiency of secretory production in silkworms and induces neutralizing antibodies in mice<\/strong><\/a>
Veterinary Research, 2021, 52:1:102-102.<\/p>\n\n\n\n

Takeru Ebihara, Jian Xu, Yoshino Tonooka, Takumi Nagasato, Kohei Kakino, Akitsu Masuda, Kosuke Minamihata, Noriho Kamiya, Hirokazu Nakatake, Yuuka Chieda, Hiroaki Mon, Tsuguru Fujii, Takahiro Kusakabe, Jae Man Lee
Active Human and Murine Tumor Necrosis Factor \u03b1 Cytokines Produced from Silkworm Baculovirus Expression System<\/a><\/strong>
Insects, 2021, 12:6:517.<\/p>\n\n\n\n

Ryo Nagai, Takeru Ebihara, Kohei Kakino, Akitsu Masuda, Jian Xu, Kosuke Minamihata, Noriho Kamiya, Tatphon Kongkrongtong, Masahiro Kawahara, Hiroaki Mon, Tsuguru Fujii, Takahiro Kusakabe, Jae Man Lee
Production of an active Mus musculus<\/em> IL-3 using updated silkworm-based baculovirus expression vector system<\/a><\/strong>
Journal of Asia-Pacific Entomology, 2021, 24:2:544-549.<\/p>\n\n\n\n

2020<\/h2>\n\n\n\n

Masato Hino, Noriko Karasaki, Tsuneyuki Tatsuke, Daisuke Morokuma, Akitsu Masuda, Hiroaki Mon, Jae Man Lee, Takahiro Kusakabe
Mild inactivation and inhibition of phenoloxidase in silkworm serum for xeno-free culture of insect cells<\/strong><\/a>
Journal of Insect Biotechnology and Sericology, 2020, 89:9-16.<\/p>\n\n\n\n

Tsuguru Fujii, Kohei Kakino, Miyu Tanaka, Jae Man Lee, Takahiro Kusakabe, Yutaka Banno
A defect in purine nucleotide metabolism in the silkworm, Bombyx mori, causes a translucent larval integument and male infertility<\/a><\/strong>
Insect Biochemistry and Molecular Biology, 2020, 126:103458.<\/p>\n\n\n\n

Ryosuke Fujita, Masato Hino, Takeru Ebihara, Takumi Nagasato, AkitsuMasuda, Jae Man Lee, Tsuguru Fujii, Hiroaki Mon, Kohei Kakino, Ryo Nagai, Miyu Tanaka, Yoshino Tonooka, Takato Moriyama, Takahiro Kusakabe
Efficient production of recombinant SARS-CoV-2 spike protein using the baculovirus-silkworm system<\/a><\/strong>
Biochem Biophys Res Commun, 2020, 529:257-262.<\/p>\n\n\n\n

Kohei Kakino, Akitsu Masuda, Masato Hino, Takeru Ebihara, Jian Xu, Hiroaki Mon, Ryosuke Fujita, Tsuguru Fujii, Takahiro Kusakabe, Jae Man Lee
Efficient production of recombinant T7 endonuclease I using silkworm-baculovirus expression vector system<\/a><\/strong>
Journal of Asia-Pacific Entomology, 2020, 23:694-700.<\/p>\n\n\n\n

Masahiko Kobayashi, Jian Xu, Kohei Kakino, Akitsu Masuda, Masato Hino, Naoki Fujimoto, Kosuke Minamihata, Noriho Kamiya, Hiroaki Mon, Hiroshi Iida, Masateru Takahashi, Takahiro Kusakabe, Jae Man Lee
Optimal silkworm larva host for high-level production of Mus musculus<\/em> IL-4 using a baculovirus expression vector system<\/a><\/strong>
Journal of Asia-Pacific Entomology, 2020, 23:1:268-273.<\/p>\n","protected":false},"excerpt":{"rendered":"

Publications 2026 Tomoki Sasaki, Akitsu Masuda, Jae Man Lee, Shigeyuki Tamiya, Yusaku Mikaki, Kiyotada Naitou, […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-110","page","type-page","status-publish","hentry"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":7}},"_links":{"self":[{"href":"https:\/\/www.agr.kyushu-u.ac.jp\/lab\/csii\/wordpress\/wp-json\/wp\/v2\/pages\/110","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.agr.kyushu-u.ac.jp\/lab\/csii\/wordpress\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.agr.kyushu-u.ac.jp\/lab\/csii\/wordpress\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.agr.kyushu-u.ac.jp\/lab\/csii\/wordpress\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.agr.kyushu-u.ac.jp\/lab\/csii\/wordpress\/wp-json\/wp\/v2\/comments?post=110"}],"version-history":[{"count":13,"href":"https:\/\/www.agr.kyushu-u.ac.jp\/lab\/csii\/wordpress\/wp-json\/wp\/v2\/pages\/110\/revisions"}],"predecessor-version":[{"id":358,"href":"https:\/\/www.agr.kyushu-u.ac.jp\/lab\/csii\/wordpress\/wp-json\/wp\/v2\/pages\/110\/revisions\/358"}],"wp:attachment":[{"href":"https:\/\/www.agr.kyushu-u.ac.jp\/lab\/csii\/wordpress\/wp-json\/wp\/v2\/media?parent=110"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}