蛋白質化学工学研究室（2017年まで）の論文発表

2017年

  • Nagata, M., Ishino, S., Yamagami, T., Simons, J-R., Kanai, T., Atomi, H., and Ishino, Y. (2017) Possible function of the second RecJ-like protein in stalled replication fork repair by interacting with Hef. Sci Rep. 7:16949. doi: 10.1038/s41598-017-17306-0.
  • 石野良純、跡見晴幸編著、(2017) アーキア生物学 共立出版
  • 石野良純 (2017) さまざまな研究環境を振り返って思うこと ～CRISPR(クリスパー)の発見～　産官学連携ジャーナル 13, 36-38.
  • Nagata, M., Ishino, S., Yamagami, T., Ogino, H., Simons, J-R., Kanai, T., Atomi, H., and Ishino, Y. (2017) The Cdc45/RecJ-like protein forms a complex with GINS and MCM, and is important for DNA replication in Thermococcus kodakarensis. Nucleic Acids Res. 45: 10693-10705. doi: 10.1093/nar/gkx740.
  • 石野良純　(2017) 遺伝子工学技術はDNA関連酵素に支えられている～制限酵素、PCRそしてゲノム編集へ～　生物工学会誌 95, 377-382.
  • 石野園子　(2017) 生命科学をめぐる幾筋もの道で出合った景色　生物工学会誌 95, 338-341.
  • Tsuchida, N., Ikeda, M., Ishino, Y., Grieco, M., and Vecchio, G. (2017) FUCA1 is induced by wild-type p53 and expressed at different levels in thyroid cancers depending on p53 status. Int. J. Oncol. 50: 2043-2048, doi: 10.3892/ijo.2017.3968
  • Antranikian, G., Suleiman, M., Schafers, C., Adams, MWW., Bartolucci, S., Blamey, JM., Birkeland, NK., Bonch-Osmolovskaya, E., da Costa, MS., Cowan, D., Danson, M., Forterre, P., Kelly, R., Ishino, Y., Littlechild, J., Moracci, M., Noll, K., Oshima, T., Robb, F., Rossi, M., Santos, H., Schonheit, P., Sterner, R., Thauer, R., Thomm, M., Wiegel, J., and Stetter, KO. (2017) Diversity of bacteria and archaea from two shallow marine hydrothermal vents from Vulcano Island. Extremophiles. 21:733–742 doi: 10.1007/s00792-017-0938-y.
  • Liu, S., Ishino, S., Ishino, Y., Pehau-Arnaudet, G., Krupovic, M., and Prangishvili, D. (2017) A novel type of polyhedral viruses infecting hyperthermophilic archaea. J. Virol. 91:e00589-17 doi: 10.1128/JVI.00589-17.
  • Ogino, H., Ishino, S., Kohda, D., and Ishino, Y. (2017) The RecJ2 protein in the thermophilic archaeon Thermoplasma acidophilum is a 3'-5' exonuclease and associates with a DNA replication complex. J. Biol. Chem. 292:7921-7931. doi: 10.1074/jbc.M116.767921.
  • Yoda, T., Tanabe, M., Tsuji, T., Yoda, T., Ishino, S., Shirai, T., Ishino, Y., Takeyama, H., and Nishida, H. (2017) Exonuclease processivity of archaeal replicative DNA polymerase in association with PCNA is expedited by mismatches in DNA. Sci. Rep. 7:44582 doi: 10.1038/srep44582
  • Shiraishi, M., Ishino, S., Cann, I., and Ishino, Y. (2017) A functional endonuclease Q exists in the bacterial domain: identification and characterization of endonuclease Q from Bacillus pumilus. Biosci. Biotechnol. Biochem. 81, 931-937. doi: 10.1080/09168451.2016.1277946.

2016年

  • 石野良純 (2016) パスツール回想2016 日本パスツール財団HP
    http://zaidan.pasteur.jp/news/researcher_2017.html
  • 石野良純（2016）CRISPRの発見から実用化までの歴史「ゲノム編集入門」第２章 ISBN 978-4-7853-5866-2
  • 石野良純 (2016）Pyrococcus furious単離30周年に寄せて 極限環境生物学会雑誌 15, 5-9.
  • 石野良純 (2016) 細菌に存在する繰り返し配列の発見からゲノム編集技術へ 大阪大学医学部学友会会誌 36, 54-59
  • Nakae, S., Hijikata, A., Tsuji, T., Yonezawa, K., Kouyama, K., Mayanagi,K., Ishino, S., Ishino, Y., and Shirai, T. (2016) Structure of the EndoMS-DNA complex as mismatch-restriction endonuclease. Structure 24, 1960-1971. doi: 10.1016/j.str.2016.09.005.
  • Oyama, T., Ishino, S., Shirai, T., Yamagami, T., Nagata, M., Ogino, H., Kusunoki, M., and  Ishino, Y. (2016) Atomic structure of an archaeal GAN suggests its dual roles as an exonuclease in DNA repair and a CMG component in DNA replication. Nucleic Acids, Res. 44, 9509-9517. doi: 10.1093/nar/gkw789
  • Abellon-Ruiz, J., Ishino, S., Ishino, Y., and Connolly, B. A. (2016) Archaeal DNA polymerase-B as a DNA template guardian: links between polymerases and base/alternative excision repair enzymes in handling the deaminated bases uracil and hypoxanthine. Archaea 2016, 1510938. eCollection 2016.
  • Richarme, G., Marguet, E., Forterre, P., Ishino, S., and Ishino Y. (2016) DJ-1 family Maillard deglycases prevent acrylamide formation. Biochem Biophys Res Commun. pii: S0006-291X(16)31332-8. DOI: 10.1016/j.bbrc.2016.08.077
  • 石野良純 (2016) CRISPR/Cas 〜その発見からゲノム編集技術への応用まで〜 生物工学会誌 94,336-342
  • Shiraishi, M., Ishino, S., Yoshida, K., Yamagami, T., Cann, I., and Ishino, Y. (2016) PCNA is involved in the EndoQ-mediated DNA repair process in Thermococcales. Sci. Rep.6: 25532. DOI: 10.1038/srep25532.
  • Ishino, S., Nishi, Y., Oda, S., Uemori, T., Sagara, T., Takatsu, N., Yamagami, T., Shirai, T., and Ishino, Y. (2016) Identification of a mismatch-specific endonuclease in hyperthermophilic Archaea. Nucleic Acids Res. 44, 2977-2986. doi: 10.1093/nar/gkw153.(Breakthrough paper in Nucleic Acids Research)

2015年

  • Ueda, T., Ishino, S., Suematsu K., Nakashima, T., Kakuta, Y., Kawarabayasi, Y., Ishino, Y., and Kimura, M. (2015) Mutation of the gene encoding the ribonuclease P RNA in the hyperthermophilic archaeon Thermococcus kodakarensis causes decreased growth rate and impaired processing of tRNA precursors. Biochem Biophys Res Commun, 468, 660-665. DOI: 10.1016/j.bbrc.2015.11.012
  • 石野良純 (2015) CRISPRの発見と遺伝子工学への応用　「進化するゲノム編集技術」第１編第１章第２節 ISBN 978-4-86043-435-9
  • Yamagami, T., Matsukawa, H., Tsunekawa, S., Kawarabayasi, Y., Ishino, S., and Ishino, Y. (2015) A longer finger-subdomain of family A DNA polymerases found by metagenomic analysis strengthens DNA binding and primer extension abilities. Gene,576: 690-695. DOI: 10.1016/j.gene.2015.10.030
  • Tanabe M, Ishino Y, and Nishida H. (2015) From structure-function analyses to protein engineering for practical applications of DNA ligase. Archaea Article ID 267570, 1-20. doi: 10.1155/2015/267570
  • Wen, L., Fukuda, M., Sunada, M., Ishino, S., Ishino, Y., Okita, T.W., Ogawa, M., Ueda, T., and Kumamaru, T. (2015) Guanine nucleotide exchange factor 2 for Rab5 proteins coordinated with GLUP6/GEF regulates the intracellular transport of the proglutelin from the Golgi apparatus to the protein storage vacuole in rice endosperm. J. Exp. Bot. 66: 6137-6147. doi: 10.1093/jxb/erv325.
  • Miyazono, K, Ishino, S, Tsutsumi, K, Ito, T, Ishino, Y, and Tanokura, M. (2015) Structural basis for substrate recognition and processive cleavage mechanisms of the trimeric exonuclease PhoExo I. Nucleic Acids Res. 43:7122-7136. doi: 10.1093/nar/gkv654.
  • Ishino, S, Makita, N, Shiraishi, M, Yamagami, T, and Ishino, Y. (2015) EndoQ and EndoV work individually for damaged DNA base repair in Pyrococcus furious. Biochimie pii: S0300-9084(15)00186-8.118: 264-269. doi: 10.1016/j.biochi.2015.06.015.
  • 石野良純 (2015) 奇妙な繰り返し配列、それがCRISPRだった　実験医学 33, 1449-1454
  • Ishino, Y., and Narumi, I. (2015) DNA repair in hyperthermophilic and hyperradioresistant microorganisms. Curr. Opin Microbiol. 25, 103-112. doi:10.1016/j.mib.2015.05.010
  • Imai, H, Miyoshi, T, Murakami, R, Ito, K, Ishino, Y, and Uchiumi, T. (2015) Functional role of the C-terminal tail of the archaeal ribosomal stalk in recruitment of two elongation factors to the sarcin/ricin loop of 23S rRNA. Genes Cells 20:613-624. doi: 10.1111/gtc.12256.
  • Shiraishi, M., Ishino, S., Yamagami, T., Egashira, Y., Kiyonari, S., and Ishino, Y. (2015) A novel endonuclease that may be responsible for damaged DNA base repair in Pyrococcus furious. Nucleic Acids Res. 43, 2853-2863.
  • Goda, N., Matsuo, N., Tenno, T., Ishino, S., Ishino, Y., Fukuchi, S., Ota, M., and Hiroaki, H. (2015) An optimized Npro-based method for expression and purification of intrinsically disordered proteins for NMR study. J. Intrinsic. Disordered Prot. 3, 1-6.
  • Ishino, S. and Ishino, Y. (2015) DNA replication in thermophilic microorganisms,InThermophilic Microorganisms.Horizon Scientific Press, Norwich, UK

2014年

  • Yamagami, T., Ishino, S., Kawarabayasi, Y., and Ishino, Y. (2014) Mutant Taq DNA polymerases with improved elongation ability as a useful reagent for genetic engineering. Front Microbiol. 5:461.
  • Ogino, H., Ishino, S., Oyama, T., Kohda, D., and Ishino, Y. (2014) Disordered interdomain region of Gins is important for functional tetramer formation to stimulate MCM helicase in Thermoplasma acidophilum. Biosci. Biotechnol. Biochem., 79,　432-438.
  • Ishino, S., and Ishino, Y. (2014) DNA polymerases as useful reagents for biotechnology - the history of developmental research in the field. Front. Microbiol. 5, 465
  • Miyazono, K., Tsutsumi, K., Ishino, Y., and Tanokura, M. (2014) Expression, high-pressure refolding, purification, crystallization and preliminary X-ray analysis of a novel single-strand-specific 3′–5′exonuclease PhoExo I from Pyrococcus horikoshii OT3. Acta Cryst. F70, 1076–1079.
  • Ogino, H., Ishino, S., Haugland, G.T., Birkeland, N-K., Kohda, D., and Ishino, Y. (2014) Activation of the MCM helicase from the thermophilic archaeon, Thermoplasma acidophilum by interactions with GINS and Cdc6-2. Extremophiles 18, 915-924
  • Ishino, S., Yamagami, T., Kitamura, M., Kodera, N., Mori, T., Sugiyama, S., Ando, T., Goda, N., Tenno, T,, Hiroaki, H., and Ishino, Y. (2014) Multiple interactions of the intrinsically disordered region between the helicase and the nuclease domains of the archaeal Hef protein. J. Biol. Chem. 289, 21627-21639
  • Kiyonari, S., Egashira, Y., Ishino, S., and Ishino, Y. (2014) Biochemical characterization of endonuclease V from the hyperthermophilic archaeon, Pyrococcus furiosus. J. Biochem. 153, 325-333.
  • Tanabe, M., Ishino, S., Ishino, Y., and Nishida, H. (2014) Mutations of Asp540 and the domain-connecting residues synergistically enhance Pyrococcus furiosus DNA ligase activity. FEBS Lett. 588, 230-235.

2013年

  • Ishino, S., Kelman, L.M., Kelman, Z., and Ishino, Y. (2013) The archaeal DNA replication machinery: past, present and future. Genes Genet. Syst. 88, 315-319
  • Ishino S, Daimon K, and Ishino Y. (2013) Molecular evolution of DNA replication machinery approached from the viewpoints of archaea. – Evolutional discussion from the distribution of DNA polymerase –. Viva Origino 41, 8-11.
  • Fukuda, M., Wen, L., Satoh-Cruz, M., Kawagoe, Y., Nagamura, Y., Thomas, W., Okita, H., Washida, H., Sugino, A., Ishino, S., Ishino, Y., Ogawa, M., Sunada, M., Ueda, T., and Kumamaru, T. (2013) A guanine nucleotide exchange factor for Rab5 proteins is essential for intracellular transport of the proglutelin from the Golgi apparatus to the protein storage vacuole in rice endosperm. Plant Physiol 162, 663-674
  • Richardson, T.T., Gilroy, L., Ishino, Y., Connolly, B.A. and Henneke, G. (2013) Novel inhibition of archaeal family-D DNA polymerase by uracil. Nucleic Acids Res.41, 4207-7218
  • Tori, K., Ishino, S., Kiyonari, S., Tahara, S. and Ishino, Y. (2013) A novel single-strand specific 3'-5' exonuclease found in the hyperthermophilic archaeon,, Pyrococcus furiosus. PLoS One, 8, e58497

2012年

  • 石野良純 (2012) 耐熱性 DNA ポリメラーゼ 〜PCRへの利用から現在まで〜
  • Kuba, Y., Ishino, S., Yamagami, T., Tokuhara, M., Kanai, T., Fujikane, R.,Daiyasu., Atomi, H., Ishino, Y.(2012) Comparative analyses of the two PCNAs from the hyperthermophilic archaeon, Thermococcus kodakarensis Genes Cells 17,923-937.
  • Ishino, Y., Ishino, S. (2012) DNA Replication in Archaea, the Third Domain of Life. In The Mechanisms of DNA Replication D. Stuart (Ed), pp. 91-126, InTech d.o.o., Rijeka, Croatia
  • Tanabe M., Ishino, S., Yohda, M., Morikawa, K., Ishino, Y., Nishida, H. (2012) Structure-based mutational study of an archaeal DNA ligase towards improvement of ligation activity ChemBioChem. 13, 2575-2582.
  • Murase, S., Ishino, S., Ishin,o Y., Tanaka, T. (2012) Control of enzyme reaction by a designed metal ion-dependent α-helical coiled-coil protein. J. Biol. Inorg. Chem.17, 791-799.
  • Kawamura, A., Ishino, Y., and Ishino, S. (2012) Biophysical analysis of PCNA from Pyrococcus furiosus.   J. Jap. Soc. Extremophiles.11, 12-18.
  • Ishino, S., Kawamura, A., and Ishino, Y. (2012) Application of PCNA to processive PCR by reducing the stability of its ring structure. J. Jap. Soc. Extremophiles. 11, 19-25.
  • Yang, Y., Ishino, S., Yamagami, T., Kumamaru, T., Satoh, H., and Ishino, Y. (2012) The OsGEN-L protein from Oryza sativa possesses Holliday junction resolvase activity as well as 5'-flap endonuclease activity. J. Biochem. 151, 317-327.
  • Ishino, S. and Ishino, Y. (2012) DNA polymerases and DNA ligases. In Thermophilic microbes in environmental and industrial biotechnologyLitterchild J., Satyanarayana, T., Kawarabayasi, Y. (Eds) pp. 429-457, Springer Science+Business Media. 
  • Ishino, Y. and Ishino, S. (2012) Rapid progress of DNA replication studies in Archaea, the third domain of life.  Sci. China, Ser-C Life Sci. 55,1-18.
  • Ishino, S and Ishino, Y. (2012) Application of environmental DNA resources to create useful DNA polymerases with different properties.  In Microorganisms in Sustainable Agriculture and Biotechnology. Satyanarayana, T. et al (Eds.), pp. 663-678, Springer Science+Business Media. 

2011年

  • Ishino, S., Fujino, S., Tomita, H., Ogino, H., Takao, K., Daiyasu, H., Kanai, T., Atomi, H., and Ishino, Y. (2011) Biochemical and genetical analyses of the three mcm genes from the hyperthermophilic archaeon, Thermococcus kodakarensis.  Genes Cells16,1176-1189.
  • Ogino, H., Ishino, S. Mayanagi, K., Haugland,G, H., Birkeland, N-K., Yamagishi, A., and Ishino Y. (2011) The GINS complex from the thermoacidophilic archaeon, Thermoplasma acidophilum may function as a homotetramer in DNA replication.  Extremophiles15, 529-539.
  • Oyama, T, Ishino, S, Fujino, S, Ogino, H, Shirai, T, Mayanagi, K, Saito, M, Nagasawa, N, Ishino, and Y, Morikawa, K. (2011) Architectures of archaeal GINS complexes, essential DNA replication initiation factors. BMC Biol. 9:28.
  • Liu, C., McKinney, MC., Chen, YH., Earnest, TM., Shi, X., Lin, LJ., Ishino, Y., Dahmen, K., Cann, I.K., Ha, T.(2011) Reverse-Chaperoning Activity of an AAA+ Protein. Biophys J. 100, 1344-1352.
  • Mayanagi, K., Kiyonari, S., Nishida, H., Saito, M., Kohda, D., Ishino, Y., Shirai, T., and Morikawa, K. (2010) Architecture of the DNA polymerase B-proliferating cell nuclear antigen (PCNA)-DNA ternary complex. Proc. Natl. Acad. Sci. USA. 108, 1845-1849.
  • 清成信一、石野良純 (2011) DNA複製をコントロールするクランプ複合体 　化学と生物 49, 9-11

2010年

  • Fujikane, R., Ishino, S., Ishino, Y., and Forterre, P. (2010) Genetic analysis of DNA repair in the hyperthermophilic archaeon, Thermococcus kodakaraensis. Genes Genet. Syst. 85, 243-257.
  • 西田洋一、真柳浩太、石野良純、森川耿右 (2010)  DNA クランプ／複製DNA ポリメラーゼ複合体における DNA 合成・修正スイッチング機構  日本結晶学会誌 52, 201-207.
  • Akita, M., Adachi, A, Takemura, K., Yamagami, T., Matsunaga, F., and Ishino, Y. (2010) Cdc6/Orc1 from Pyrococcus furiosus may act as the origin recognition protein and Mcm helicase recruiter. Genes Cells 15, 537-552.
  • Lin, L-J., Yoshinaga, A., Lin, Y., Guzman, C., Chen, Y-H., Mei, S., Lagunas, A. M., Koike, S., Iwai, S., Spies, M. A., Nair, S. K., Mackie, R. I., Ishino, Y., and Cann, I. K. O. (2010)　Molecular analyses of an unusual translesion DNA polymerase from Methanosarcina acetivorans C2A. J. Mol. Biol. 397, 13-30.
  • Tori, K., Dassa, B., Johnson, M. A., Southworth, M. W., Brace, L. E., Ishino, Y., Pietrokovski, S., and Perler, F. B. (2010) Splicing of the Mycobacteriophage Bethlehem DnaB intein: identification of a new mechanistic class of inteins that contain an obligate Block F nucleophile. J. Biol. Chem. 285, 2515-2526.

2009年

  • 石野園子、石野良純 (2009) 耐熱性クランプ分子：環状構造の安定性と機能の関係　生化学  81, 1056-1063.
  • 石野良純 (2009) 極限環境で働くタンパク質の特徴と利用〜極限環境で働くタンパク質はどこが違うのか？〜　生化学  81, 1035-1037.
  • Nishida, H., Mayanagi, K., Kiyonari, S., Sato, Y., Oyama, T., Ishino, Y., and Morikawa, K. (2009) Structural determinant for switching between the polymerase and exonuclease modes in the PCNA-replicative DNA polymerase complex. Proc. Natl. Acad. Sci. USA. 106, 20693-20698.
  • Matsunaga, F., Takemura, K., Akita, M., Adachi, A., Yamagami, T., and Ishino, Y. (2009) Localized melting of duplex DNA by Cdc6/Orc1 at the DNA replication origin in the hyperthermophilic archaeon Pyrococcus furiosus. Extremophiles 14, 21-31.
  • Morii H, Kiyonari S, Ishino Y, and Koga Y. (2009) A novel biosynthetic pathway of archaetidyl-myo-inositol via archaetidyl-myo-inositol phosphate from CDP-archaeol and D-glucose 6-phosphate in the methanoarchaeon Methanothermobacter thermautotrophicus cells. J. Biol. Chem. 284, 30766-30774.
  • Kiyonari, S., Tahara, S., Shirai, T., Iwai, S., Ishino, S., and Ishino, Y. (2009) Biochemical properties and BER complex formation of AP endonuclease from Pyrococcus furiosus Nucleic Acids Res.37, 6439-6453.
  • Chen, Y-H., Lin, Y., Yoshinaga, A., Chhotani, B., Lorenzini, J., Crofts, A., Mei, S., Mackie, R.I., Ishino, Y., and Cann, I.K.O. (2009) Molecular analyses of a three-subunit euryarchaeal clamp loader complex from Methsnosarcina acetivorans.  J. Bacteriol., 191, 6539-6549.
  • Mayanagi. K., Kiyonari, S., Saito, M., Shirai, T., Ishino, Y., and Morikawa, K. (2009)Mechanism of replication machinery assembly as revealed by the DNA ligase-PCNA-DNA complex architechture. Proc. Natl. Acad. Sci. USA. 106, 4647-4652.
  • Oyama, T., Oka, H., Mayanagi, K., Shirai, T., Matoba, K., Fujikane, R., Ishino, Y., and Morikawa, K. (2009)   Atomic structures and functional implications of the archaeal RecQ-like helicase Hjm. BMC Structural Biology 9, 2 (2-12)
  • Matsukawa, H., Yamagami, T.,Kawarabayasi, Y., Miyashita, Y., Takahashi, M., and Ishino, Y. (2009) A useful strategy to construct DNA polymerases with different properties by using genetic resources from environmental DNA. Genes Genet. Syst. 84, 3-13.
  • 石野園子 、石野良純 (2009) アーキアの DNA トランスアクション　〜その共通性と多様性〜、 蛋白質核酸酵素   54, 141-147.
  • 石野良純 (2009) アーキア：第３の不思議な生物　特集にあたって 蛋白質核酸酵素   54, 101-107.
  • Kiyonari, S., Tahara, S., Uchimura, M., Shirai, T., Ishino, S., and Ishino, Y. (2009) Studies on base excision repair (BER) complex in Pyrococcus furiosus. Biochem. Soc. Trans. 37, 79-82.

2008年

  • Kiyonari, S., Uchimura, M., Shirai, T., Ishino, Y.  (2008) Physical and functional interactions between uracil-DNA glycosylase and proliferating cell nuclear antigen from the euryarchaeon Pyrococcus furiosus. J. Biol. Chem. 283,24185-24193.
  • Yoshimochi, T., Fujikane, R., Kawanami, M., Matsunaga, F., and Ishino, Y.  (2008) The GINS complex from Pyrococcus furiosus stimulates the MCM helicase activity. J. Biol. Chem. 283, 1601-1609.
  • 石野良純 (2008) DNA 複製フォーク進行停止とその修復の分子機構〜古細菌からヒト遺伝病まで〜   RADIOISOTOPES, 57, 467-470.
  • 石野良純 (2008)  巻頭言「フランス、パリ郊外より」極限環境微生物学会誌   7, 2

2007年

  • Tori, K., Kimizu, M., Ishino, S., Ishino, Y.  (2007) DNA Polymerase BI and D from the hyperthermophilic archaeon, Pyrococcus furiosus both bind to proliferating cell nuclear antigen with their C-terminal PIP-box motif.  J. Bacteriol., 189, 5652-5657.
  • Kiyonari, S., Kamigochi, T., and Ishino, Y. (2007) A single amino acid substitution in the DNA-binding domain of Aeropyrum pernix DNA ligase impairs its interaction with proliferating cell nuclear antigen, Extremophiles 11, 675-684.
  • Nishida H, Tanabe M, Ishino Y, Oyama T, Morikawa K. (2007) Crystallization and preliminary crystallographic study of DNA polymerase from Pyrococcus furiosus. Protein Pept Lett. 14, 403-405.
  • Matsunaga, F., Glatigny, A., Mucchielli-Giorgi, M. H., Agier, N., Delacroix, H., Marisa, M., Durosay, P., Ishino, Y., Aggerbeck, L., and Forterre, P. (2007) Genomewide and Biochemical Analyses of DNA-binding activity of Cdc6/Orc1 and Mcm proteins in Pyrococcus sp. Nucleic Acids Res. 35, 3214-3222.
  • Imamura, K., Fukunaga, K., Kawarabayasi, Y., and Ishino, Y. (2007) Specific interactions of three PCNAs with replication-related proteins in Aeropyrum pernix. Mol. Microbiol. 64, 308-318.
  • 清成信一、石野良純 DNA リガーゼの構造と機能〜アーキアからの発見〜 (2007) 化学と生物 、 45,705-711.
  • 石野良純 、山上　健、松川博昭、鬼塚尚子、鍋　健吾、興梠聖哉 (2007)メタゲノムを利用した新規DNA合成酵素の創製　 環境バイオテクノロジー学会誌, 7, 87-92.

2006年

  • Kiyonari, S., Takayama, K., Nishida, H., and Ishino, Y. (2006) Identification of a novel binding motif in Pyrococcus furiosus DNA ligase for the functional interaction with proliferating cell nuclear antigen. J. Biol. Chem. 281, 28023-28032.
  • Nishida, H., Kiyonari, S., Ishino, Y., and Morikawa, K. (2006) The closed structure of an archaeal DNA ligase from Pyrococcus furiosus. J. Mol. Biol. 360, 956-967.
  • Ishino, S. and Ishino Y. (2006) Conprehensive search for DNA polymerase in the hyperthermophilic archaeon, Pyrococcus furiosus. Nucleosides, Nucleotides, and Nucleic Acids. 25, 681-691.
  • Nishida, H., Matsumiya, S., Tsuchiya, D., Ishino, Y., Morikawa, K. (2006) Stoichiometric complex formation by proliferating cell nuclear antigen (PCNA) and its interacting protein: purification and crystallization of the DNA polymerase and PCNA monomer mutant complex from Pyrococcus furiosus. Acta Cryst. F62, 253-256.
  • Fujikane, R., Shinagawa, H., Ishino, Y. (2006) The archaeal Hjm helicase has recQ-like functions, and may be involved in repair of stalled replication fork. Genes Cells. 11, 99-110.
  • Ishino, Y., Nishino, T., Morikawa, K. (2006) Mechanisms of Maintaining Genetic Stability by Homologous Recombination. Chem Rev. 106, 324-339.
  • Nishino, T., Ishino Y., Morikawa, K. (2006) Structure-specific DNA nucleases: structural basis for 3D-scissors. Curr. Opin. Struct. Biol. 16, 1-8.
  • 鈴木博文、宮田知子、真柳浩太、大山拓次、石野良純、森川 耿右 (2006) DNA クランプをはめ込むしくみー単粒子解析で見えた生き生きとした姿　生物物理 46, 345-348.

2005年

  • Namba, K., Hagiwara, K., Tanaka, H., Nakaishi, Y., Chong, K.T., Yamashita, E., Armah, G.E., Ono, Y., Ishino, Y., Omura, T., Tsukihara, T., Nakagawa, A. (2005) Expression and molecular characterization of spherical particles derived from the genome of the hyperthermophilic euryarchaeote Pyrococcus furiosus. J. Biochem. 138, 193-199.
  • Nishida, H., Tsuchiya, D., Ishino, Y., Morikawa, K. (2005) Overproduction, purification and crystallization of an archaeal DNA ligase from Pyrococcus furiosus. Acta Cryst. F61, 1100-1102.
  • Miyata, T., Suzuki, H., Oyama, T., Mayanagi, K., Ishino, Y., Morikawa, K. (2005) Open clamp structure in the clamp-loading complex visualized by electron microscopic image analysis.  Proc Natl Acad Sci USA. 102, 13795-13800.
  • Nishida, H., Ishino, S., Miyata, T., Morikawa, K., Ishino, Y (2005) Identification of the critical region in Replication factor C from Pyrococcus furiosus for the stable complex formation with proliferating cell nuclear antigen and DNA. Genes Genet. Syst. 80, 83-93.
  • Nishino, T., Komori, K.,Ishino, Y., Morikawa, K. (2005) Structural and functional analyses of an archaeal XPF/Rad1/Mus81 nuclease: asymmetric DNA binding and cleavage mechanisms.  Structure 13, 1183-1192.
  • Fujikane, R., Komori, K., Shinagawa, H.,Ishino, Y. (2005) Identification of a novel helicase activity unwinding branched DNAs from the hyperthermophilic archaeon, Pyrococcus furiosus. J. Biol. Chem. 280, 12351-12358.
  • Nishino, T., Komori, K., Tsuchiya, D., Ishino, Y., Morikawa, K. (2005) Crystal structure and functional implications of Pyrococcus furiosus Hef helicase domain involved in branched DNA processing. Structure 13,143-153.
  • 石野良純  (2005) DNA複製、修復研究から遺伝子解析技術開発へ DNA 多型 13, 1-13.

2004年

  • Komori K, Hidaka M, Horiuchi T, Fujikane R, Shinagawa H, Ishino Y. (2004) Cooperation of the N-terminal helicase and C-terminal endonuclease activities of archaeal Hef protein in processing stalled replication fork. J. Biol. Chem. 279, 53175-53185.
  • Hishida, T, Han, YW, Shibata, T, Kubota, Y, Ishino, Y, Iwasaki, H, Shinagawa, H. (2004) Role  of the Escherichia coli RecQ DNA helicase in SOS signaling and genome stabilization at stalled replication forks. Genes Dev. 18, 1886-1897.
  • Miyata, T, Oyama, T, Mayanagi, K, Ishino, S, Ishino, Y, Morikawa, K. (2004) The clamp-loading complex for processive DNA replication. Nat. Struct. Mol. Biol. 7, 11632-11636.
  • Ishino, Y., Nakabeppu, Y., Maki, H., Iwasaki, H., Araki, H., Shinagawa, H.(2004) The 4th International Symposium on 3R; DNA replication, recombination and repair.  Genes Genet Syst. 79, 53-63.

2003年以前

  • Ishino, S., Oyama, T., Yuasa, M., Morikawa, K., and Ishino, Y. (2003) Mutational Analysis of Pyrococcus furiosus Replication Factor C based on the Three-Dimensional Structure. Extremophiles 7, 169-175.
  • Nishino, T., Komori, K., Ishino, Y., and Morikawa, K. (2003) X-ray structural and biochemical anatomy of an archaeal XPF/Rad1/Mus81 family nuclease: a novel domain arrangement and a striking similarity between its central endonuclease domain and type II restriction enzymes. Structure 11, 445-457.
  • Matsumiya, S., Ishino, S., Ishino, Y., and Morikawa, K. (2003) Intermolecular ion pairs maintain toroidal structure of Pyrococcus furiosus PCNA. Prot. Sci. 12, 823-831.
  • Jolivet, E., Matsunaga, F., Ishino, Y., Forterre, P., Prieur, D., and Myllykallio, H. (2003) Physiological responses of the hyperthermophilic archaeon Pyrococus abyssi to DNA damage caused by ionizing radiation. J. Bacteiol. 185, 3958-3961.
  • Komori, K., Fujikane, R., Shinagawa, H., and Ishino, Y. (2002) Novel endonuclease in Archaea cleaving DNA with various branched structure. Genes Genet. Syst. 77, 227-241.
  • Matsumiya, S., Ishino, S., Ishino, Y., and Morikawa, K. (2002) Physical interaction between proliferating cell nuclear antigen and replication factor C from Pyrococcus furiosus. Genes Cells, 7, 911-922.
  • Daimon, K., Kawarabayasi, Y., Kikuchi, H., Sako, Y., and Ishino, Y. (2002) Three proliferating cell nuclear antigen-like proteins found in the hyperthermophilic archaeon, Aeropyrum pernix: interactions with the two DNA polymerases. J. Bacteriol. 184, 687-694.
  • Liu, L., Komori, K., Ishino, S., Bocquier, A., Cann, I., Kohda, D., and Ishino, Y. (2001) The archaeal DNA primase: biochemical characterization of the p41-p46 complex from Pyrococcus furiosus. J. Biol. Chem. 276, 45484-45490.
  • Matsunaga, F., Forterre, P., Ishino, Y., and Myllykallio, H. (2001) In vivo interactions of archaeal Cdc6/Orcl and minichromosome maintenance proteins with the replication origin.  Proc. Natl. Acad. Sci. USA 98, 11152-11157.
  • Oyama, T., Ishino, Y., Cann, I., Ishino, S., and Morikawa, K. (2001) Atomic structure of the clamp loader small subunit from Pyrococcus furiosus. Mol. Cell 8, 455-463.
  • Daiyasu, H., Osaka, K., Ishino, Y., and Toh, H. (2001) Expansion of the zinc metallo-hydrolase family of the -lactamase fold. FEBS Lett. 503, 1-6.
  • Nishino, T., Komori, K., Ishino, Y., and Morikawa, K (2001) Dissection of the regional roles of the archaeal Holliday junction resolvase Hjc by structural and mutational analyses. J. Biol. Chem. 276, 35735-35740.
  • Komori, K., and Ishino, Y. (2001) Replication protein A in Pyrococcus furiosus is involved in homologous DNA recombination. J. Biol. Chem. 276, 25654-25660.
  • Ishino, Y., Tsurimoto, T., Ishino, S., and Cann, I. (2001) Functional interactions of an archaeal sliding clamp with mammalian clamp loader and DNA polymerase Genes Cells 6, 699-706.
  • Mayanagi, K., Miyata, T., Oyama, T., Ishino, Y., and Morikawa, K. (2001) Three-dimensional electron microscopy of clamp loader small subunit from Pyrococcus furiosus. J. Struct. Biol. 134, 35-45.
  • Bocquier, A., Liu, L., Cann, I., Kohda, D., and Ishino, Y. (2001) Archaeal primase: bridging the gap between RNA and DNA polymerase. Curr. Biol. 11, 452-456.
  • Cann, I., Ishino, S., Yuasa, M., Daiyasu, H., Toh, H., Morikawa, K., and Ishino, Y. (2001) Biochemical analysis of the replication factor C from the hyperthermophilic archaeon Pyrococcus furiosus. J. Bacteriol. 183, 2614-2623.
  • Nishino, T., Komori, K., Tsuchiya, D., Ishino, Y., and Morikawa, K. (2001) Crystal structure of the archaeal Holliday junction resolvase Hjc and implications for DNA recognition.  Structure 9, 197-204.
  • Matsumiya, S., Ishino, Y., and Morikawa, K. (2001) Crystal structure of an archaeal DNA sliding clamp: proliferating cell nuclear antigen of Pyrococcus furiosus. Protein Sci. 10, 17-23.
  • Ishino, Y. and Ishino, S. (2001) Novel DNA polymerases from Euryarchaeota. Meth. Enzymol. 334, 249-260.
  • Ohnishi, T., Iwasaki, H., Ishino, Y., Kuramitsu, S., Nakata, A., and Shinagawa, S. (2000) Identification and characterization of Thermus thermophilus HB8 RuvA protein, the subunit of the RuvAB protein complex that promotes branch migration of Holliday junctions. Genes Genet. Syst. 75, 233-243.
  • Komori, K., Sakae, S., Daiyasu, H., Toh, H., Morikawa, K., Shinagawa, H., and Ishino, Y. (2000) Mutational analysis of the Pyrococcus furiosus Holliday junction resolvase Hjc revealed functionally important residues for dimer formation, junction DNA binding, and cleavage activities. J. Biol. Chem. 275, 40385-40391.
  • Komori, K., Sakae, S., Fujikane, R., Morikawa, K., Shinagawa, H., and Ishino, Y. (2000) Biochemical characterization of the Hjc Holliday junction resolvase of Pyrococcus furiosus.  Nucleic Acids Res. 28, 4544-4551.
  • Daiyasu, H., Komori, K., Sakae, S., Ishino, Y., and Toh, H. (2000) Hjc resolvase is a distantly related member of the Type II restriction endonuclease family. Nucleic Acids Res. 28, 4540-4543.
  • Komori, K., Miyata, T., Daiyasu, H., Toh, H., Shinagawa, H., and Ishino, Y. (2000) Domain analysis of an archaeal RadA protein for the strand exchange activity. J. Biol. Chem. 275, 33791-33797.
  • Komori, K., Miyata, T., DiRuggiero, J., Holley-Shanks, R., Hayashi, I., Cann, I., Mayanagi, K., Shinagawa, H., and Ishino, Y. (2000) Both RadA and RadB are involved in homologous recombination in Pyrococcus furiosus. J. Biol. Chem. 275, 33782-33790.
  • Ichiyanagi, K., Ishino, Y., Ariyoshi, M., Komori, K., and Morikawa, K. (2000) Crystal structure of an archaeal intein-encoded homing endonuclease PI-PfuI. J. Mol. Biol. 300, 889-901.
  • Komori, K., and Ishino, Y. (2000) Functional interdependence of DNA polymerizing and 3'→5' exonucleolytic activities in Pyrococcus furiosus DNA polymerase I. Protein Eng. 13, 41-47.
  • Cann I., and Ishino, Y. (1999) Archaeal DNA replication: Identifying the pieces to solve a puzzle.  Genetics 152, 1249-1267.
  • Hayashi, I., Morikawa, K., and Ishino, Y. (1999) Specific interaction between DNA polymerase II (PolD) and RadB, a Rad51/Dmcl homolog, in Pyrococcus furiosus. Nucleic Acids Res.27, 4695-4702.
  • Komori, K., Ichiyanagi, K., Morikawa, K., and Ishino, Y. (1999) PI-PfuI and PI-PfuII, intein-coded homing endonucleases from Pyrococcus furiosus. II. Characterization of the binding and cleavage abilities by site-directed mutagenesis. Nucleic Acids Res. 27, 41 75-4182.
  • Komori, K., Fujita, N., Ichiyanagi, K., Shinagawa, H., Morikawa, K., and Ishino, Y. (1999) PI-PfuI and PI-PfuII, intein-coded homing endonucleases from Pyrococcus furiosus. I. Purification and identification of the homing-pype endonuclease activities. Nucleic Acids Res.27, 4167-4174.
  • Cann, I., Ishino, S., Hayashi, I., Komori, K., Toh, H., Morikawa, K., and Ishino, Y. (1999) Functional interactions of a homolog of proliferating cell nuclear antigen with DNA polymerases in Archaea. J. Bacteriol. 181, 6591-6599.
  • Cann, I., Ishino, S., Nomura, N., Sako, Y., and Ishino, Y. (1999) Two family B DNA polymerases in Aeropyrum pernix, an obligate aerovic hyperthermophilic crenarchaeote. J. Bacteriol. 181, 5984-5992.
  • Komori, K., Sakae, S., Shinagawa, H., Morikawa, K., and Ishino, Y. (1999) A novel Holliday junction resolvase: functional similarity to E. coli RuvC provides evidence for conserved mechanism of homologous recombination in Bacteria, Eukarya, and Archaea. Proc. Natl. Acad. Sci. USA 96, 8873-8878.
  • Ishino, Y. and Cann, I (1998) The euryarchaeotes, a subdomain of archaea, survive on a single DNA polymerase: fact or farce?  Genes Genet. Syst. 73, 323-336.
  • Cann, I., Komori, K., Toh, H., Kanai, S., and Ishino, Y. (1998) A heterodimeric DNA polymerase: evidence that members of the euryarchaeota possess a novel DNA polymerase.  Proc. Natl. Acad. Sci. USA 95, 14250-14255.
  • Cann, I., Kanai, K., Toh, H., and Ishino, Y. (1998) Adenylosuccinate synthetase genes: molecular cloning and phylogenetic analysis of a highly conserved archaeal gene. System. Appl. Microbiol. 21, 478-486.
  • Ishino, Y., Komori, K., Cann, I., and Koga, Y. (1998) A novel DNA polymerase family found in Archaea. J. Bacteriol. 180, 2232-2236.
  • Cann, I., and Ishino, Y. (1998) A tRNAGlu gene from the hyperthermophilic archaeon Pyrococcus furiosus contains the 3'-terminal CCA sequence of the mature tRNA. FEMS Microbiol. Lett. 160, 199-204.
  • Yamazaki, T., Otomo, T., Oda, N., Kyogoku, Y., Uegaki, K., Ito, N., Ishino, Y. and Nakamura, N. (1998) Segmental isotope labeling for protein NMR using peptide splicing. J. Am. Chem. Soc. 120, 5591-5592.
  • Uemori, T., Sato, Y., Kato, I., Doi, H., and Ishino, Y. (1997) A novel DNA polymerase in the hyperthermophilic archaeon, Pyrococcus furiosus. Gene cloning, expression, and characterization. Genes Cells 2, 499-512.
  • Ueno, H., Kita, A., Miyahara, M., Ishiwata, N., Mise, K., Kato, K., and Ishino, Y. (1997) Production of new restriction endonuclease VpaK11BI recognizing sequence 5'-GGWCC-3' in a haemolysin-less mutant of Vibrio parahaemolyticus. Biosci. Biotech. Biochem. 61, 2129-2130.
  • Mitsuda, N., Nakura, J., Ye, L., Zhao, Y., Fujioka, Y., Takahashi-Fujii, A., Ishino, Y., Kato, I., Hashimoto, K., Ogihara, T., and Miki, T. (1997) A high-density STS map based on a single contig of YAC and P1 clones in the chromosome 8p12-p2l region. Genomics41, 49-55.
  • Inagi, R., Guntapong, R., Nakao, M., Ishino, Y., Kawanishi, K., Isegawa, Y., and Yamanishi, K. (1996) Human herpesvirus 6 induces IL-8 gene expression in human hepatoma cell line, Hep G2. J. Med. Virol. 49, 34-40.
  • Iwaki,T., Kawamura, A., Ishino, Y., Kohno, K., Kano, Y., Goshima, N., Doi, H., Furusawa, M., and Imamoto, F. (1996) Preferential replication-dependent mutagenesis in the lagging DNA strand in Escherichia coli. Mol. Gen. Genet. 251, 657-664.
  • Ueno, H., Kato, I., and Ishino, Y. (1996) Cloning and expression of the BalI restriction-modification system. Nucleic Acids Res. 24, 2268-2270.
  • Nakura, J., Ye, L., Takahashi-Fujii, A., Ishino, Y., Kato, I., Miki,T., and Ogihara, T. (1996) Two dinucleotide repeat polymorphisms at the D8S1445 loci. Jpn. J. Hum. Genet. 41, 261-263.
  • Ye, L., Nakura, J., Mitsuda, N., Takahashi-Fujii, A., Ishino, Y., Kato, I., Miki, T., and Ogihara, T. (1996) Dinucleotide repeat polymorphism at the D8S1444. Jpn. J. Hum. Genet41, 257-259.
  • Ishino, Y., Takahashi-Fujii, A., Uemori, T., Imamura, M., Kato, I., and Doi, H. (1995) The amino acid sequence required for 5'→3' exonuclease activity of Bacillus caldotenax DNA polymerase. Protein Eng. 8, 1171-1175.
  • Ishino, Y., Nomura, Y., and Kato, I. (1995) Sse8647I, a new type II restriction endonuclease from a Streptomyces species cutting at 5'-AG/GWCCT-3'. Nucleic Acids Res. 23, 742-744.
  • Nomura, Y., Ishino, Y., Kimizuka, F., and Kato, I. (1995) A novel Streptomyces restriction endonuclease, Sse1825I, cleaving at 5'-GG/GWCCC-3'. Gene 157, 323-324.
  • Ye, L., Nakura, J., Mitsuda, N., Takahashi-Fujii, A., Ishino, Y., Kato, I., Miki, T., and Ogihara, T. (1995) A highly polymorphic dinucleotide repeat at the D8Sl222 locus. Jpn. J. Hum. Genet. 40, 287-288.
  • Mitsuda, N., Nakura, J., Ye, L., Miki, T., Takahashi-Fujii, A., Ishino, Y., and Ogihara, T. (1995) Dinucleotide repeat polymorphism at D8S1054. Jpn. J. Hum. Genet. 40, 215-216.
  • Imamura, M., Uemori, T., Kato, I., and Ishino, Y. (1995) A non--like DNA polymerase from a hyperthemophilic archaeon Pyrococcus furiosus. Biol. Pharm. Bull. 18, 1647-1652.
  • Uemori, T., Ishino, Y., Doi, H., and Kato, I. (1995) The hyperthermophilic archaeon Pyrodictium occultum has two -like DNA polymerases. J. Bacteriol. 177, 2164-2177.
  • Ishino, Y., Ueno, T., Miyagi, M., Uemori, T., Imamura, M., Tsunasawa, S., and Kato, I. (1994) Overproduction of Thermus aquaticus DNA polymerase and its structural analysis by ion-spray mass spectrometry. J. Biochem. 116, 1019-1024.
  • Ishino, Y., Iwasaki, H., Kato, I., and Shinagawa, H. (1994) Amino acid sequence motifs essential to 3'→5' exonuclease activity of Escherichia coli DNA polymerase II. J. Biol. Chem. 269, 14655-14660.
  • Nakura, J., Ye, L., Mitsuda, N., Takahashi-Fujii, A., Ishino, Y., Miki,T., and Ogihara, T. (1994) Six dinucleotide repeat polymorphisms on chromosome 7. Jpn. J. Hum. Genet. 39, 447-449.
  • Nakura, J., Ye, L., Mitsuda, N., Takahashi-Fujii, A., Ishino, Y., Miki, T., and Ogihara, T. (1994) Dinucleotide repeat polymorphism at the D8Sl053. Jpn. J. Hum. Genet. 39, 445-446.
  • Ye, L., Kihara, K., Nakura, J., Kamino, K., Mitsuda, N., Takahashi-Fujii, A., Ishino, Y., Miki, T., and Ogihara, T. (1994) Dinucleotide repeat polymorphism at the D8S1055. Jpn. J. Hum. Genet. 39, 441-443.
  • Ye, L., Nakura, J., Miki, T., Kihara, K., Nagano, K., Mitsuda, N., Kamino, K., Ogihara, T., Takahashi-Fujii, A., and Ishino, Y. (1994) Dinucleotide repeat polymorphism at D7S813. Hum. Mol. Genet. 3, 385.
  • Takahashi-Fujii, A., Ishino, Y., Kato, I., and Fukumaki, Y. (1994) Rapid and practical detection of -thalassemia by fluorescence based PCR-single-stranded conformation polymorphism analysis. Mol. Cell. Probes 8, 385-393.
  • Takahashi-Fujii, A., Maeda, N., Ishino, Y., Kotani, H., and Kato, I. (1994) Non-isotopic restriction mapping of cosmid DNA. BioTechnique 16, 910-914.
  • Uemori, T., Ishino, Y., Fujita, K., Asada, K., and Kato, I. (1993) Cloning of the Bacillus caldotenax DNA polymerase gene and characterization of the gene product. J. Biochem. 113, 401-410.
  • Mineno, J., Ishino, Y., Ohminami, T., and Kato, I. (1993) F1uorescent labeling of a DNA sequencing primer. DNA SEQUENCE4, 135-141.
  • Takahashi-Fujii, A., Ishino, Y., Shimada, A., and Kato, I. (1993) Practical application of the fluorescence-based image analyzer for PCR-single-stranded conformation polymorphism analysis used in detection of multiple point mutations. PCR Methods Applic. 2, 323-327.
  • Uemori, T., Ishino, Y., Toh, H., Asada, K., and Kato, I. (1992) Organization and nucleotide sequence of the DNA polymerase gene from the archaeon Pyrococcus furiosus. Nucleic Acids Res. 21, 259-265.
  • Ishino, Y., Morgenthaler, P., Hottinger, H., and Soll, D. (1992) Organization and nucleotide sequence of the glutamine synthetase (glnA) gene from Lactobacillus delbuekii subsp. bulgaricus. Appl. Environ. Microbiol. 58, 3165-3169.
  • Ishino, Y., Iwasaki, H., Fukui, H., Mineno, J., Kato, I. and Shinagawa, H. (1992) Aphidicolin inhibits DNA polymerizing activity but not nucleolytic activity of Escherichia coli DNA polymerase II. Biochimie74, 131-136.
  • Ishino, Y. (1992) Rapid and reliable DNA sequencing with a dideoxy sequencing kit. Am. Biotechnol. Lab. 10, 47.
  • Ishino, Y., Mineno, J., Inoue, T., Fujimiya, H., Yamamoto, K., Tamura, T., Homma, M., Tanaka, K., and Kato, I. (1992) Practical application in molecular biology of sensitive fluorescence detection by a laser-excited fluorescence image analyzer. BioTechnique13, 936-943.
  • Shinagawa, H., Iwasaki, H., Ishino, Y., and Nakata, A. (1991) SOS-inducible DNA polymerase II of E. coli is homologous to replicative DNA polymerase of eukaryotes. Biochimie73, 433-435.
  • Iwasaki, H., Ishino, Y., Toh, H., Nakata, A., and Shinagawa, H. (1991) Escherichia coli DNA polymerase II is homologous to -like DNA polymerases. Mol. Gen. Genet. 226, 24-33.
  • Mineno, J., Fukui, H., Ishino, Y., Kato, I., and Shinagawa, H. (1990) Nucleotide sequence of the araD gene of Escherichia coli K12 encoding the L-ribulose 5-phosphate 4-epimerase.  Nucleic Acids Res. 18, 6722.
  • Jahn, D., Kim, Y-C., Ishino, Y., Chen, M-W., and Soll, D. (1990) Purification and functional characterization of the Glu-tRNA amidotransferase from Chlamydomonas reinhardtii. J. Biol. Chem.256, 8059-8064.
  • Asada, K., Ishino, Y., Shimada, M., Shimojo, T., Endo, M., Kimizuka, F., Kato, I., Maki, M., and Murachi, T. (1989) cDNA cloning of human calpastatin:  Sequence homology among human, pig, and rabbit calpastatins. J. Enzyme Inhibition 3, 49-56.
  • Ishino, Y., Shinagawa, H., Makino, K., Amemura, M., and Nakata, A. (1987) Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli, and identification of the gene product. J. Bacteriol. 169, 5429-5433.
  • Ishino, Y., Shinagawa, H., Makino, K., Tsunasawa, S., Sakiyama, F., and Nakata, A. (1986) Nucleotide sequence of the lig gene and primary structure of DNA 1igase of Escherichia coli.  Mol. Gen. Genet. 204, 1-7.
  • Ishino, Y., Shibahara, S., Ohtsuka, E., and Ikehara, M. (1986) Restricted joining of a decadeoxyribonucleotide for preparation of an eicosadeoxyribonucleotide duplex containing recognition sites for restriction enzymes. Nucleosides and Nucleotides5, 471-480.
  • Ohtsuka, E., Ishino, Y., Ibaraki, K., and Ikehara, M. (1983) Recognition by restriction endonuclease EcoRI of deoxyoctanucleotides containing modified sugar moieties. Eur. J. Biochem. 139, 447-450.
  • 農学研究院 生命機能科学部門 生物機能分子化学講座 生物化学分野
  • 生物資源環境科学府 生命機能科学専攻 生物機能分子化学コース 生物化学分野
  • 農学部 応用生物科学コース 応用生命化学分野 生物化学研究室
  • Biological Chemistry, Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences
  • システム生命科学府 生命工学講座 構造分子生物学研究室
  • Structural and Molecular Biology, Division of Life Engineering, Graduate School of Systems Life Sciences
Copyright © Tomoyuki Numata, All Rights Reserved.